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A blend selected from Asteraceae tomentosa and Mangosteen for metabolic syndrome control

A technology of Asteria tomentosa, mixtures for use in the field of mixtures selected from Asteria tomentosa and Mangosteen for the control of metabolic syndrome

Active Publication Date: 2011-12-21
LAILA NUTRACEUTICALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0025] A brief review of the existing literature shows that there is no report on the use of compounds containing S. tomentosa and mangosteen to treat metabolic syndrome or improve metabolic marker proteins

Method used

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  • A blend selected from Asteraceae tomentosa and Mangosteen for metabolic syndrome control
  • A blend selected from Asteraceae tomentosa and Mangosteen for metabolic syndrome control
  • A blend selected from Asteraceae tomentosa and Mangosteen for metabolic syndrome control

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0205] Ethyl acetate extract of S. tomentosa (LI / DD-H / 054A / 01): S. tomentosa flower heads (2.2kg) were used as the experimental extract and extracted with ethyl acetate (22L) at reflux temperature for 2 hours . The extract was filtered and the extraction of the spent material was repeated twice with ethyl acetate (2 x 13 L) under the same conditions. The combined extracts were fine filtered and concentrated in a rising film evaporator to obtain a residue (174g). Analysis by high performance liquid chromatography showed that the ethyl acetate extract contained 11% of 7-hydroxy-4,11(13)diketenone-12,6-lactone (7-hydroxyorcinone).

Embodiment 2

[0207] N-hexane extract of S. tomentosa (LI / DD-H / 054A / 02): Put S. tomentosa flower heads (1.0 kg) into a Soxhlet apparatus and extract with n-hexane (6 L) at reflux temperature for 4 hours, the extract was fine-filtered, and the spent material was extracted twice more with n-hexane (2x4L). The extracts were combined and concentrated under vacuum to obtain a residue (43 g). Analysis by high performance liquid chromatography showed that the n-hexane extract contained 21% of 7-hydroxytyrolactone.

Embodiment 3

[0209]Methanol extract of S. tomentosa (LI / DD-H / 054A / 03): Put S. tomentosa flower heads (1.0 kg) into an RB flask and extract with methanol (8 L) at 80°C for 2 After 1 hour, the extract was filtered and the extraction of the spent material was repeated twice with methanol (2x6L) under the same conditions. The combined extracts were fine filtered and concentrated in a rising film evaporator to obtain a residue (110 g). Analysis by high performance liquid chromatography showed that the methanolic extract contained 8.3% of 7-hydroxytyrolactone.

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Abstract

The invention relates to pharmaceutical / dietary supplement / food ingredient(s) selected from the extract(s), fraction(s), active compound(s) and phytochemical(s) or mixtures thereof derived from Sphaeranthus indicus and their compositions, preferably in combination with at least one component selected from the extract(s), fraction(s), active compound(s) and phytochemical(s) or mixtures thereof derived from Garcinia mangostana. The ingredients and the composition(s) can be used for the control, prevention and treatment of obesity, metabolic syndrome, diabetes and other metabolic disorders, and also to regulate energy expenditure, prevention of atherosclerotic plaques in coronary artery and abdominal aorta, increase insulin sensitivity, improve glucose tolerance, lower triglyceride levels and balance glucose levels in mammals.

Description

Technical field: [0001] The present invention relates to novel pharmaceutical or dietary supplements comprising at least one compound selected from the group consisting of extracts, fractions, active compounds and phytochemicals or mixtures thereof and one selected from the group consisting of extracts, fractions of Mangosteen , active compounds and phytochemicals or mixtures thereof, optionally including one or more pharmaceutically or dietaryly acceptable diluents, media, carriers, actives or mixtures thereof. [0002] The present invention further relates to at least one compound selected from extracts, fractions, active compounds, phytochemicals or mixtures thereof of S. tomentosa and mixtures thereof, preferably together with at least one extract, fraction selected from mangosteen , active compounds and phytochemicals or mixtures thereof, for use in metabolic syndrome or obesity, and / or one or more diseases associated with or associated with metabolic syndrome and metabol...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/00
CPCA23L1/3002A23V2002/00A61K36/38A61K36/28A23L33/105A61K31/365A61K45/06A61K31/352A61P1/14A61P17/00A61P25/00A61P25/28A61P3/00A61P3/04A61P35/00A61P3/06A61P37/00A61P37/04A61P9/00A61P9/10A61P9/12A61P3/10A61K2300/00A23V2250/21A61K31/343A23V2200/30A61K35/12A61K31/19A61K31/437A61K31/5377
Inventor 冈加·拉吉·古卡拉吉拉玛·拉吉·古卡拉吉文卡塔·肯纳卡·兰加·拉吉·古卡拉吉崔姆尔土卢·古兰扣堤吉兰·布帕蒂拉吉克里斯南·森古普塔文卡塔·克里斯南·拉吉·阿汝李
Owner LAILA NUTRACEUTICALS
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