Small cluster water zinc supplementation oral liquid, and preparation method and application thereof

A technology of oral liquid and clusters, which is applied in the direction of pharmaceutical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., and can solve problems such as zinc that has not yet been seen

Inactive Publication Date: 2012-01-11
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, there is no direct experimental evidence on whether zinc can be absorbed by the intestinal tract through intercellular diffusion in the existing literature at home and abroad.

Method used

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  • Small cluster water zinc supplementation oral liquid, and preparation method and application thereof
  • Small cluster water zinc supplementation oral liquid, and preparation method and application thereof
  • Small cluster water zinc supplementation oral liquid, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Example 1 Preparation of Small Cluster Water Zinc Supplement Oral Liquid

[0038] 1. Weigh 210mg of zinc gluconate and dissolve it in 100ml of distilled water. The pH of the solution was then adjusted to 4 with picoline carboxylic acid.

[0039] 2. Sonicate to accelerate the dissociation of zinc ions.

[0040] 3. Pass the prepared solution above through a spectrum analyzer with a frequency of 60 Hz (a container with an AC electric field), and process it for 10 seconds, so that the zinc in the solution can form a stable zinc-enriched small cluster water with the small cluster water, and the final solution The half width of the NMR spectrum is 64.03Hz. It shows that the water molecules in the solution have become small clusters of water.

[0041] 4. Add 10 mg of sucralose to the above treated solution to fully dissolve it in the solution.

[0042] 5. Add 10 mg of essence to the solution obtained in the third step above.

[0043] 6. After the above solution is...

Embodiment 2

[0045] Since most metal ions can form corresponding ligands with water after dissociation, some can exist stably and some cannot exist stably because of their different stability conditions. Zn in aqueous solution 2+ Available with 4 or 6 H 2 The O atoms with lone pairs of electrons in O are coordinated, and the coordinated H 2 The H atoms in O can combine with other water molecules due to hydrogen bonds, thus forming small clusters of water and Zn 2+ Coordinated to form Zn 2+ (H 2 O) m.

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Abstract

The invention discloses a small cluster water zinc supplementation oral liquid, and a preparation method and application thereof. The small cluster water zinc supplementation oral liquid comprises ingredients of zinc medicament, methylpyridine acid, sweetener and edible essence. The invention combines a characteristic that small cluster water can be easily absorbed by cells and a characteristic that methylpyridine acid can promote zinc absorption with zinc supplementation; water molecule cluster is treated into small clusters and coordinated with zinc to form zinc coordinated water, which haszinc as a center and 6-8 surrounding water molecules; and the obtained small cluster water zinc supplementation oral liquid has a higher absorptivity than an ordinary zinc oral liquid.

Description

technical field [0001] The invention relates to the technical field of medicine preparation, in particular to a method for using picolinic acid to promote the absorption of zinc by the human body and the principle of bionics, and using microwave or alternating electric field treatment to prepare small cluster water zinc supplement oral liquid. Background technique [0002] In recent years, the research on the structure and function of water molecular clusters has become one of the hotspots in the frontier of scientific research. Its in-depth research is expected to provide a useful tool for revealing the essential problems in the fields of physical chemistry and life science. Various theoretical calculations and experimental researches All prove that: under natural conditions, water exists in the form of molecular clusters, and the microstructure of water has important biological functions. Under the action of hydrogen bonds, water molecules in ordinary water associate with...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/191A61K47/22A61P3/12
Inventor 皮江蔡继业
Owner JINAN UNIVERSITY
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