Chinese medicinal composition for antagonizing side effect caused by chlorpromazine and preparation method thereof

A technology of antipsychotic drugs and compositions, which is applied in the field of traditional Chinese medicine compositions and their preparations, can solve the problems of no western medicine, the inability to judge the difference in curative effect between western medicine and traditional Chinese medicine, and no reports of side effects of antipsychotic drugs, so as to achieve the effect of definite curative effect

Inactive Publication Date: 2012-01-18
BEIJING ANDING HOSPITAL CAPITAL MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the pathogenesis theory of the side effects of antipsychotic drugs is only inferred, and there is no analysis on how to apply western medicine and the relationship between the two, and there is no comparative study with western medicine, so it is impossible to judge the difference in efficacy between western medicine and traditional Chinese medicine
There is no domestic literature report on systematic research on etiology, patho...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0082] Embodiment 1: oral liquid

[0083] 1200g of raw gypsum, 150g of wine rhubarb, 300g of raw rehmannia, 300g of scrophulariae, 300g of Radix Radix, 300g of Radix Radix, 400g of Spatholobus, 300g of fried malt;

[0084] Preparation:

[0085] Add raw gypsum to 20 times water and extract for 30 minutes, then add the rest of the traditional Chinese medicine, use 10 times the amount of water, and extract twice at 100°C, each extraction time is 1.5-2 hours;

[0086] Combine the liquid medicines and filter, concentrate the filtrate to a certain volume, let it cool, add 1200-1500ml of 95% ethanol, and stir well. Refrigerate for 24-48 hours or more, take it out, and filter. The filtrate recovers ethanol and concentrates to obtain effective parts.

[0087] Add 0.2% stevioside and 0.05% ethyl p-hydroxybenzoate, dissolve and refrigerate for 24 hours, and filter to supplement the filtrate.

[0088] The above-mentioned oral solution is filled and sealed in ampoules, and sterilized a...

Embodiment 2

[0089] Embodiment 2: capsules

[0090] 1500g of raw gypsum, 150g of wine rhubarb, 300g of raw rehmannia, 300g of scrophulariae, 300g of Radix Radix, 300g of Radix Radix, 400g of Spatholobus, 300g of fried malt;

[0091] Add 20 times the amount of water to the raw gypsum and extract it for 30 minutes, then add the rest of the traditional Chinese medicine, use 10 times the amount of water, and extract twice at 100°C, each extraction time is 1.5-2 hours. Combine the liquid medicines and filter, concentrate the filtrate to a certain volume, let it cool, add 1200-1500ml of 95% ethanol, and stir well. Refrigerate for 24-48 hours or more, take out, and filter; the filtrate recovers ethanol and concentrates to obtain effective parts. The above-mentioned effective parts are dried under reduced pressure to obtain a medicinal powder; the above-mentioned medicinal powder is prepared without adding or adding a small amount of lactose as an auxiliary material, and the granules are prepared...

Embodiment 3

[0092] Embodiment 3: Granules

[0093] 1000g of raw gypsum, 140g of wine rhubarb, 310g of raw rehmannia, 320g of scrophulariae, 310g of Radix Radix, 300g of Radix Radix, 400g of Spatholobus, 300g of fried malt;

[0094] The preparation method is:

[0095]Add 20 times the amount of water to the raw gypsum and extract it for 30 minutes, then add the rest of the traditional Chinese medicine, use 10 times the amount of water, and extract twice at 100°C, each extraction time is 1.5-2 hours. Combine the liquid medicines and filter, concentrate the filtrate to a certain volume, let it cool, add 1200-1500ml of 95% ethanol, and stir well. Refrigerate for 24-48 hours or more, take out, and filter; the filtrate recovers ethanol and concentrates to obtain effective parts. The above-mentioned effective parts are dried under reduced pressure to obtain a medicinal powder; the medicinal powder is added with an appropriate amount of auxiliary material lactose, mixed uniformly in an equal amo...

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Abstract

The invention discloses a Chinese medicinal composition for antagonizing side effects caused by a chlorpromazine and a preparation method thereof. Bulk pharmaceuticals of the Chinese medicinal composition comprise gypsum, wine-treated rhubarb, unprocessed rehmannia root, figwort root, dwarf lilyturf root, suberect spatholobus stem and the like. The preparation method comprises the following stepsof: extracting gypsum with water and adding other bulk pharmaceuticals for performing water extraction; and purifying the extract with ethanol at a certain concentration, and the like. A composition preparation (gypsum-rhubarb hear clearing oral liquid) disclosed by the invention has a definite curative effect on the aspect of antagonizing side effects caused by the chlorpromazine.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition and a preparation method thereof, in particular to a traditional Chinese medicine composition for antagonizing side effects caused by psychotropic drugs and a preparation method thereof. Background technique [0002] Mental illness is a common and serious disease, which can cause brain dysfunction due to different reasons and manifest a variety of mental symptoms, seriously endangering human physical and mental health. With the development of society and the continuous improvement of people's living standards, people's mental pressure increases, and the incidence of mental diseases is on the rise. At present, the etiology of many mental illnesses is still unknown, so they cannot be treated fundamentally. Patients with mental illness need to take medicine for a long time, ranging from 3-5 years, and most patients need to take medicine for life. [0003] Side effects caused by antipsyc...

Claims

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Application Information

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IPC IPC(8): A61K36/8998A61P39/02
Inventor 王彦恒冯秀杰马良贾竑晓杜万君庄红艳
Owner BEIJING ANDING HOSPITAL CAPITAL MEDICAL UNIV
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