Unlock instant, AI-driven research and patent intelligence for your innovation.
Method for extracting chimaphilin from one-flowered wintergreen
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A technology of Plumbine and Dulihua, applied in the direction of organic chemistry, quinone separation/purification, etc., to achieve the effect of less pollution, beneficial to large-scale production operations, and low energy consumption
Inactive Publication Date: 2013-09-04
SUZHOU PAITENG BIOLOGICAL MEDICAL TECH
View PDF3 Cites 0 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
[0005] In the prior art, there is no report on the preparation process applicable to the large-scale industrial production of high-purity mericarin
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0023] Take 10Kg of the fresh aboveground part of Diliflower, add 80L of saturated lime water, soak at 30°C for 24 hours, squeeze and filter, collect the filtrate, decolorize it through an activated carbon column, collect the lower column liquid, concentrate, and absorb it through a D101 macroporous adsorption resin column , eluted with 60% ethanol, collected 3 times the eluate of the column volume, recovered ethanol under reduced pressure and concentrated, added n-hexane to crystallize, separated and crystallized, washed and dried to obtain 24.2g of merasin, which was detected by HPLC. 96.1%, UV, IR, MS, 2 HNMR, 13 The data characterizing its physical properties such as CNMR are consistent with the prior art.
Embodiment 2
[0025] Take 10Kg of the fresh aerial part of Diliflower, add 120L of saturated lime water, soak for 36 hours at 70°C, squeeze and filter, collect the filtrate, decolorize it through an activated carbon column, collect the next column liquid, concentrate, and pass it through H-50 macroporous adsorption resin Adsorbed on the column, eluted with 80% ethanol, collected the eluate with 8 times the volume of the column, recovered the ethanol under reduced pressure and concentrated, added n-hexane to crystallize, separated the crystals, washed and dried to obtain 25.9g of meresin, which was detected by HPLC , with a purity of 95.3%, UV, IR, MS, 2 HNMR, 13 The data characterizing its physical properties such as CNMR are consistent with the prior art.
Embodiment 3
[0027] Take 10Kg of the fresh aboveground part of Diliflower, add 100L of saturated lime water, soak for 30 hours at 50°C, squeeze and filter, collect the filtrate, decolorize it through an activated carbon column, collect the next column liquid, concentrate, and pass it through a CD-180 macroporous adsorption resin Column adsorption, eluted with 70% ethanol, collected eluate with 5 times the volume of the column, recovered ethanol under reduced pressure and concentrated, added n-hexane to crystallize, separated the crystals, washed and dried to obtain 25.4 g of merasin, which was detected by HPLC , with a purity of 97.5%, UV, IR, MS, 2 HNMR, 13 The data characterizing its physical properties such as CNMR are consistent with the prior art.
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
PUM
Login to View More
Abstract
The invention relates to a method for extracting chimaphilin from one-flowered wintergreen, which is easy and convenient to operate and has small pollution and low energy consumption. The method comprises the following process steps of: extracting a fresh aboveground part of one-flowered wintergreen; adding saturated lime water; soaking for 24-36 hours; squeezing and filtering; collecting a filtrate; decoloring with an active carbon column; collecting a column unloading liquid; concentrating; adsorbing with a macroporous absorption resin column; eluting with 60-80 percent ethanol; collecting an eluent which is 3-8 times the volume of the column; recovering ethanol under reduced pressure and concentrating; adding n-hexane for crystalizing; separating crystals; and washing and drying. Due to the adoption of the method for preparing chimaphilin, the product purity is high and industrial amplification is easy to realize.
Description
technical field [0001] The invention relates to a method for preparing merasin, in particular to a method for extracting merasin from plants. Background technique [0002] Chimaphilin, molecular formula: C 12 h 10 o 2 , Molecular weight: 186.21, CAS accession number: 482-70-2, mainly exists in various plants of Wintergreenaceae, among which the unique flower of Wintergreenaceae Moneses uniflora A. Gray is rich in content. Its molecular formula is as follows. [0003] [0004] Modern studies have shown that mericatin has antitumor, antibacterial, anti-inflammatory, analgesic and other effects, and it is also used as a raw material for the synthesis of other active derivatives. [0005] In the prior art, there is no report on the preparation process applicable to the large-scale industrial production of high-purity merasalin. Contents of the invention [0006] The technical problem to be solved by the present invention is to provide a method for preparing merasalin...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to View More 
Login to View More