Method for preparing nebivolol hydrochloride

Abstract

The invention discloses a method for preparing nebivolol hydrochloride. An L-nebivolol hydrochloride with four chiral centers and a D-nebivolol hydrochloride with four chiral centers are obtained through carrying out processes of bromination, a wittig reaction, a reduction reaction, a hydrolysis reaction, a condensation reaction, a chiral inversion reaction, a ring-opening addition reaction, a hydrogenation debenzylation reaction, salt forming and the like on raw materials consisting of a simple achiral compound and a cheap chiral aldehyde with only one chiral center. The process of the invention, which has the advantages of cheap and easily available raw material, mild reaction condition, and no pollution to environment, is suitable for the industrialization production.

Description

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AI Technical Summary

Benefits of technology

This patented technology involves making certain chemical substances by reacting two different starting products together through specific steps that involve adding other molecules called nucleophiles (nucleators) beforehand. These new ingredients help make it easier to produce these desired chemical compositions while reducing environmental concerns associated therewith.

Problems solved by technology

In summary, technical problem addressed in this patents relates to improving methods for making nibebufoquidp rosette or similar drugs like Nebulinopristate without reducing their quality due to impurities such as α-cyclodystrophylic acid residue from starting material.

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