Method for preparing nebivolol hydrochloride
A compound, the technology of dichloromethane, applied in the field of preparing nebivolol hydrochloride, can solve the problems of harsh reaction conditions, high cost, and many synthesis steps, and achieve mild reaction conditions, low price, and cheap and easy-to-obtain raw materials Effect
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[0047] The present invention will be further described below through specific implementation in the form of examples. It should be understood that the preparation methods of the examples of the present invention are only used to illustrate the present invention, rather than limit the present invention, and the simple improvements to the preparation methods of the present invention under the premise of the concept of the present invention all belong to the protection scope of the present invention.
[0048] 1. (R, R)-2-(2',2'-dimethyl-[1,3]-dioxol-4-yl)-6-fluoro-4-chromanone and (S, Preparation of R)-2-(2', 2'-dimethyl-[1,3]-dioxolan-4-yl)-6-fluoro-4-chromanone (formula II)
[0049]
[0050] 1. Preparation of 2-bromo-1-(5-fluoro-2-hydroxyphenyl)ethanone
[0051]
[0052] Add 5-fluoro-2-hydroxyacetophenone (160g, 1.03mol) and copper bromide (500g, 2.24mol) into a 3L three-neck flask, then add ethyl acetate (700mL) and dichloromethane (700mL), and stir The temperature was...
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