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Method for preparing astragalus polysaccharide glucose-lowering capsule

A hypoglycemic and capsule technology, applied in the field of preparation of traditional Chinese medicine, can solve the problem of large dosage

Active Publication Date: 2013-09-25
JILIN AODONG YANBIAN PHARM CO LTD
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

[0003] The invention provides a preparation method of Jinqi Jiangtang Capsules to solve the problem of large dosage of the original medicine

Method used

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  • Method for preparing astragalus polysaccharide glucose-lowering capsule
  • Method for preparing astragalus polysaccharide glucose-lowering capsule
  • Method for preparing astragalus polysaccharide glucose-lowering capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0010] Prescription: Coptis chinensis 206g, Astragalus 308g, Honeysuckle 1236g;

[0011] (1) Take 1 / 3 of the prescription and pulverize it into fine powder, and extract the remaining coptis and astragalus together with 70% ethanol for three times. , combine the extracts, stand at 4°C for 12 hours, pour out the supernatant, filter, and recover ethanol from the filtrate under reduced pressure and concentrate it to a thick paste with a relative relative density of 1.20 to 1.25 at 50°C;

[0012] (2) Take honeysuckle and add 20 times the amount of water and soak it three times, each time for 1 hour, combine the leaching solution, let stand at 4 °C overnight, pour out the supernatant, filter, and measure the relative density when the filtrate is concentrated to 25 °C under reduced pressure. The relative density of 1.15 ~ 1.20 of the clear paste, add ethanol to make the alcohol content reach 70%, stand at 4 ° C for 24 hours, filter, the filtrate is decompressed to recover ethanol and...

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Abstract

The invention relates to a method for preparing an astragalus polysaccharide glucose-lowering capsule, which belongs to the method for preparing Chinese medicines. After repetition tests of refluxing extractive of coptis chinensis and astragalus ethanol and honeysuckle warm immersion alcohol settling conditions, the optimal extractive process of the preparation is determined through screening of an orthogonal method. Loss of effective constituents is effectively reduced in production and more impurities are removed. Compared with the prior art, clinical dose is reduced by 60%, bioavailability of the preparation is improved, and the purpose of reducing dose under the premise of the same curative effect is achieved.

Description

technical field [0001] The invention belongs to a preparation method of traditional Chinese medicine. Background technique [0002] The original dosage form of Jinqi Jiangtang Capsule is capsule, which has been used clinically for many years and has good curative effect. However, patients report that the dosage is large (7-10 capsules at a time). The main reason for the large dosage is the large amount of powder in the prescription. Prescription Coptis 206g, Astragalus 308g, Honeysuckle 1236g, including Coptis chinensis, very bitter in taste, capsules can cover up its bitter taste, easy to take, disintegrate faster than tablets and pills, release drugs quickly, and the drugs contained are not affected by adhesives and Under the influence of pressure, it can quickly diffuse into gastric juice, so capsules are still selected for the current dosage form. SUMMARY OF THE INVENTION [0003] The invention provides a preparation method of Jinqi Jiangtang capsules, so as to solve ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K36/718A61P3/10
Inventor 王永宽刘全李伟李光振王大鹏刘良梅常芳
Owner JILIN AODONG YANBIAN PHARM CO LTD
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