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Medicinal composition for treating ophthalmic diseases and preparation method thereof

An ophthalmic disease and composition technology, which is applied in the field of traditional Chinese medicine compound prescriptions for the treatment of ophthalmic diseases and its preparation field, can solve the problems affecting the curative effect of traditional Chinese medicine for ophthalmology, the complex composition of the traditional Chinese medicine, the obsolescence, etc., so as to improve the bioavailability of the medicine, prolong the Residence time, the effect of improving the efficacy of the drug

Inactive Publication Date: 2012-02-29
CHANGCHUN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Due to the complex composition of traditional Chinese medicine, the dosage forms and preparations of traditional Chinese medicine and its compound prescriptions used to treat ophthalmic diseases are relatively outdated and backward, which seriously affects the efficacy of ophthalmic Chinese medicine.

Method used

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  • Medicinal composition for treating ophthalmic diseases and preparation method thereof
  • Medicinal composition for treating ophthalmic diseases and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1: Preparation of ophthalmic gel eye drops of the present invention

[0022] Pearl 10g, chrysanthemum 1g, coptis 1g, bear bile 0.1g, stone cassia 1g, rehmannia glutinosa 1g, borneol 0.1g;

[0023] Preparation method:

[0024] (1) Cassia officinale was calcined at 200°C for 2 hours, quenched in 0.5 times the amount of vinegar, the acid content of the vinegar was 9%, repeatedly calcined and quenched until the vinegar was exhausted, covered, dried in a crucible, and crushed for 60 Mesh sieve;

[0025] (2) Calcined stone Cassia, Chrysanthemum, Coptidis, Rehmannia glutinosa and Pearl add 8 times the amount of water, extract 2 times, each time is 2h, 1h respectively, combine the extracts, concentrate to 50 °C and measure the relative density of 1.11. Cream; extract twice with 6 times the amount of 90% ethanol, each time for 2 hours and 1 hour respectively, combine the extracts, concentrate to 50°C and measure the extract with a relative density of 1.30;

[0026]...

Embodiment 2

[0027] Embodiment 2 Preparation of ophthalmic patch of the present invention

[0028] Pearl 30g, Chrysanthemum 5.5g, Coptidis 5.5g, Bear bile 2.55g, Cassia 5.5g, Rehmannia glutinosa 5.5g, Borneol 2.55g;

[0029] Preparation method:

[0030] (1) Cassia officinale was calcined at 350°C for 1.25 hours, quenched in 1.75 times the amount of vinegar, the acid content of the vinegar was 6.5%, repeatedly calcined and quenched until the vinegar was exhausted, dried with a crucible cover, and crushed through a 60-mesh sieve ;

[0031] (2) Calcined stone Cassia, Chrysanthemum, Coptidis, Rehmannia glutinosa and Pearl add 9 times the amount of water, extract 3 times with water, each time is 2h, 1h, 1h, combine the extracts, concentrate to 50°C and measure the relative density of 1.18 extracted extract with 8 times the amount of 70% ethanol for 3 times, each time being 2h, 1h, and 1h respectively, combined the extract, concentrated to 70°C, and measured the extract with a relative density...

Embodiment 3

[0033] The preparation of embodiment 3 tablet of the present invention

[0034] Pearl 50g, chrysanthemum 10g, coptis 10g, bear bile 5g, stone cassia 10g, rehmannia glutinosa 10g, borneol 5g.

[0035] Preparation method:

[0036] (1) Cassia japonica was calcined at 500°C for 0.5 hours, quenched in 3 times the amount of vinegar, the acid content of the vinegar was 4%, repeatedly calcined and quenched until the vinegar was exhausted, covered, dried in a crucible, and crushed to 60 mesh screen;

[0037] (2) Calcined stone cassia, chrysanthemum, coptis, rehmannia glutinosa and pearl add 10 times the amount of water, extract 3 times with water, each time 2h, 1h, 1h, combine the extracts, concentrate to 50°C and measure the extract with a relative density of 1.25 Cream; extract 3 times with 10 times the amount of 50% ethanol, each time for 2h, 1h, 1h, combine the extracts, concentrate to 50°C and measure the extract with a relative density of 1.33;

[0038] (3) Add bear bile, born...

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Abstract

The invention which relates to a medicinal composition for treating ophthalmic diseases and a preparation method thereof belongs to the field of traditional Chinese medicines. The medicinal composition is prepared from the following raw medicines, by weight, 10-50 parts of pearl, 1-10 parts of chrysanthemum, 1-10 parts of coptis, 0.1-5 parts of bear gall, 1-10 parts of abalone shell, 1-10 parts of Radix Rehmanniae Praeparata and 0.1-5 parts of borneol. The medicinal composition is a medicinal composition for treating ophthalmic diseases comprising cataract and asthenopia which have symptoms of eyestrain, eye acerbity and distending pain, eye dryness, blurred vision, and the like.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine compound prescription for treating ophthalmic diseases and a preparation method thereof. Background technique [0002] Cataract is the number one blinding eye disease in the world and also in my country. According to the statistics of the World Health Organization (WHO), about 40% of the blind people in the world are blind due to cataract, and WHO incomplete statistics have 27 million to 35 million blind people in the world. Among them, there are 16-21 million cataract blind people. Therefore, all countries are actively developing anti-cataract drugs for prevention and early treatment of cataract, and early control of cataract has become a research hotspot in this field. [0003] At present, there are many types of drugs for the treatment of cataracts. Western medicines are mainly anti-oxidative damage drugs, anti-quinone body preparatio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/804A61P27/02A61P27/12A61K31/045A61K35/413A61K35/56A61K35/618
Inventor 李超英张大方杨辛欣王楚赢张超
Owner CHANGCHUN UNIV OF CHINESE MEDICINE
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