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Metabolites for oral health and uses thereof

A metabolite, health technology, applied to oral health metabolites and their applications, which can solve problems such as unclear mechanism details

Inactive Publication Date: 2012-03-07
COLGATE PALMOLIVE CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, despite the wealth of published information, the broad scope of host-bacteria interactions and the mechanistic details of disease processes on cellular biochemical metabolism remain unclear

Method used

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  • Metabolites for oral health and uses thereof
  • Metabolites for oral health and uses thereof
  • Metabolites for oral health and uses thereof

Examples

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Embodiment

[0084] The following examples further describe and demonstrate some of the embodiments that fall within the scope of the present invention. These examples are given for the purpose of illustration only and are not to be construed as limitations of the invention, since many variations thereof are possible without departing from the scope and spirit of the invention.

[0085] I. Experimental procedure

[0086] A. Experimental Design and Patients

[0087]Twenty-two (22) chronic periodontitis patients (41% male) aged 33 to 67 years (53 ± 11 ) were selected as research volunteers at the Forsyth Institute Dental Clinic. Patients had at least 20 natural uncrowned teeth and periodontal pocket depth ≥ 5 mm and clinical attachment level (CAL) ≥ 3 mm in ≥ 8 locations. The patient had an unknown history of allergy to dentifrices that underwent a washout period (see below). Exclusion criteria included: presence of orthodontic appliances; abnormal salivary function; use of prescription...

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Abstract

The present invention provides various methods of using metabolite profiles correlated with periodontal disease or a health oral status for the diagnosis of periodontal disease, identification of responders and, or non-responders to therapeutic agents for periodontal disease, a method to test the efficacy of test compounds to prevent periodontal disease. The present invention also provides for a dentifrice composition containing an effective amount of a metabolite therapeutic agent which brings about a greater change in metabolite levels compared to a control dentifrice composition.

Description

field of invention [0001] The present invention relates to differential expression profiles of metabolites in periodontal disease and methods for diagnosing periodontal disease based on these differential expression profiles. The present invention also relates to a method of predicting and / or evaluating the efficacy of a therapeutic agent for periodontal disease based on said differential expression profile. Background of the invention [0002] Periodontal disease is one of the most common infectious diseases in humans (Pihlstrom et al., 2005). In addition to affecting oral tissues, periodontal disease is also associated with various systemic diseases (Seymour et al., 2007). Gingivitis, a mild form of the disease, is characterized by host tissue inflammation and accumulation of bacterial plaque around the gingival margin. Treatment of gingivitis through improved oral hygiene practices can significantly reverse the condition. However, if left untreated, gingivitis can lead...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/50
CPCG01N33/5038G01N33/5091G01N2800/18
Inventor V·M·巴恩斯H·M·特里维迪徐韬
Owner COLGATE PALMOLIVE CO
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