New application of compound pharmaceutical composition

A composition and drug technology, applied in the field of new uses of compound pharmaceutical compositions, can solve problems such as gastric mucosal barrier damage, and achieve the effects of high efficiency and clear efficacy

Inactive Publication Date: 2013-11-06
SICHUAN XUHUA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Direct contact of bile with gastric mucosa generally does not cause damage, but it can stimulate the secretion of gastric acid. The combination of bile salt and gastric acid can enhance the activity of acid hydrolase, destroy lysosomes, dissolve lipoproteins in the membrane, and destroy the barrier function of gastric mucosa. H+ reverses Increased diffusion into the mucosa and submucosa can stimulate mast cells to release histamine, which in turn stimulates the secretion of gastric acid and pepsin, eventually leading to gastric mucosal inflammation, erosion and bleeding Bile is mixed with pancreatic juice Lecithin in bile and phosphatase A in pancreatic juice It acts and converts into lysolecithin, which can also cause damage to the gastric mucosal barrier when refluxed into the stomach

Method used

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  • New application of compound pharmaceutical composition
  • New application of compound pharmaceutical composition
  • New application of compound pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027]The preparation of embodiment 1 medicine of the present invention

[0028] 1. Prescription:

[0029] 173g of ox gall water, 115g of fire salt, 133g of gallinaceous gold (stir-fried), 52g of citrus aurantii (stir-fried with bran), 68g of Cyperus cyperi (made), 34g of woody fragrance, 34g of Corydalis (made with vinegar), 21g of Coptis chinensis, Atractylodes macrocephala (stir-fried with bran) ) 68g, Evodia (stir-fried) 27g, galangal 41g, hawthorn (stir-fried) 68g, Jianqu 141g, Qingpi 34g;

[0030] Excipients: starch 20g, magnesium stearate 5g.

[0031] The above raw and auxiliary materials are made into 1000 tablets of the medicine of the present invention.

[0032] 2. Process and operation

[0033] (1) Take stir-fried chicken neigold, Jianqu and fire salt, mix them, pulverize them according to the "Technical Safety Operation Method for Crushing Posts", pass through a 120-mesh sieve, and finely powder them for later use.

[0034] (2) Take green bark, woody fragrance,...

Embodiment 2

[0049] The preparation of embodiment 2 medicines of the present invention

[0050] a. Weigh the raw materials with the following weight proportions: 300g of ox gallbladder water, 150g of fire salt, 200g of gallinaceous gold, 90g of Citrus aurantium, 100g of Cyperus cyperi, 50g of woody incense, 55g of Corydalis Corydalis, 40g of Coptidis Rhizome, 120g of Atractylodes macrocephala, 45g of Evodia rutaecarpa, Galangal 80g, Hawthorn 120g, Jianqu 200g, Qingpi 60g; (The raw materials can use processed products or not)

[0051] b. Take gallinaceous gold and fire salt and grind them into fine powder, set aside;

[0052] c. Take Jianqu and grind it or extract it with heated water to obtain hot water extract;

[0053] d. Heat the ox gall water to boiling, filter, and concentrate the filtrate to obtain a clear paste;

[0054] e. Extract volatile oil from green bark, woody scent, Atractylodes macrocephala, Citrus aurantii, Cyperus cyperi, Evodia rutaecarpa, and galangal by steam distill...

Embodiment 3

[0056] Embodiment 3 preparation of medicine of the present invention

[0057] a. Weigh the following raw materials in the following weight ratio: 150g of ox gall water, 100g of fire salt, 100g of gallinaceous gold, 30g of Citrus aurantium, 30g of Cyperus cyperi, 20g of woody fragrance, 20g of Corydalis Corydalis, 10g of Coptidis Rhizome, 40g of Atractylodes macrocephala, 10g of Evodia rutaecarpa, Galangal 20g, Hawthorn 40g, Jianqu 120g, Qingpi 20g;

[0058] b. Take gallinaceous gold and fire salt and grind them into fine powder, set aside;

[0059] c. Take Jianqu and grind it or extract it with heated water to obtain hot water extract;

[0060] d. Heat the ox gall water to boiling, filter, and concentrate the filtrate to obtain a clear paste;

[0061] e. Extract volatile oils from green bark, woody scent, Atractylodes macrocephala, Citrus aurantii, Cyperus cyperi, Evodia rutaecarpa, and galangal by supercritical flow. The volatile oils are encapsulated with β-cyclodextrin, a...

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Abstract

The invention provides an application of a pharmaceutical composition in the preparation of medicaments for treating bile reflux gastritis, wherein the pharmaceutical composition is prepared by the following raw materials by weight: 150-300 parts of ox gall water, 100-150 parts of potassium nitrate, 100-200 parts of chicken gizzard membrane, 30-90 parts of citrus aurtantium, 30-100 parts of rhizoma cyperi, 20-50 parts of radix aucklandiae, 20-55 parts of corydalis tuber, 10-40 parts of coptis chinensis, 40-120 parts of atractylodes rhizome, 10-45 parts of fructus evodiae, 20-80 parts of galagal rhizome, 40-120 parts of hawthorn, 120-200 parts of medicated leaven, and 20-60 parts of pericarpium citri reticulatae viride. Clinical tests and animal efficacy tests demonstrate that the medicament of the invention can treat bile reflux gastritis, and has a high effective rate, and the application of the medicament of the invention provides new medicament selection for clinic.

Description

technical field [0001] The invention relates to a new application of a compound drug, in particular to an application in preparing a drug for treating bile reflux gastritis, and belongs to the field of drugs. Background technique [0002] Gastritis is inflammation of the gastric mucosa. According to the severity of mucosal damage, gastritis can be divided into erosive gastritis and non-erosive gastritis, and can also be classified according to the part of the stomach involved (such as cardia, gastric body, gastric antrum). According to the type of inflammatory cells, gastritis can be further divided into acute gastritis and chronic gastritis histologically. In 1982, the domestic gastritis conference divided acute gastritis into four types: acute simple gastritis, acute erosive gastritis, acute erosive gastritis, and acute suppurative gastritis, with the former two being the most common. The nomenclature of chronic gastritis is not uniform. According to different diagnosti...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9062A61P1/04A61K33/00A61K35/37A61K35/413
Inventor 谢李张文杰李伟
Owner SICHUAN XUHUA PHARMA
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