Novel application of tetrahydrocurcumin

A technology of tetrahydrocurcumin and uses, applied in the field of tetrahydrocurcumin, can solve the problems of type 2 diabetes, high blood sugar, and there is no report that tetrahydrocurcumin treats obese type 2 diabetes, etc., and achieves the effect of clear drug effect

Inactive Publication Date: 2010-06-16
SICHUAN ACAD OF CHINESE MEDICINE SCI
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

Insulin resistance and insulin secretion defects are the basis of type 2 diabetes. Although the initial pancreatic β cells can compensate for insulin resistance, the blood sugar concentration can still maintain normal, but when the body cannot compensate for the rise in blood sugar caused by insulin resistance, the blood suga

Method used

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  • Novel application of tetrahydrocurcumin
  • Novel application of tetrahydrocurcumin
  • Novel application of tetrahydrocurcumin

Examples

Experimental program
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Example Embodiment

[0028] Example 1 Preparation of tetrahydrocurcumin compounds

[0029] Pass as figure 1 The synthetic route realizes the synthesis of various derivatives of tetrahydrocurcumin (curcuma diphenylheptanes with different retention of double bonds, related glucuronic acid conjugates, sulfonates of glucuronic acid conjugates, etc.). This process involves three key issues: the selectivity in the synthesis of various polysubstituted aldehydes; the selective deprotection of ethyl acetoacetate and full condensation; the choice of hydrogenation positions in the conversion of curcumin analogs to various degrees of hydrogenation products. In the past research, it has been discovered that Lewis acid selectively removes the aromatic ring hydroxyl protection group and the aromatic aldehyde multi-substitution method has multiple options. The first and second key problems can be solved with multiple alternative methods. As for the third problem, the degree of reduction and the location of the redu...

Example Embodiment

[0030] Example 2 Effect of tetrahydrocurcumin (THC) on appetite, body weight, blood sugar and blood lipids of normal mice

[0031] KM mice were adaptively fed for 3 days and then experimented. The 60 mice were randomly divided into 5 groups according to the fasting blood glucose level, with 12 mice in each group. Set up a normal control group, THC three dose groups (5, 15, 50mg / Kg), a positive control group (Glibenclamide 25mg / Kg), each group was administered with different concentrations of ig (the normal control group was given Isometric 0.5% sodium carboxymethyl cellulose), three concentrations of THC are 0.05%, 0.15%, 0.5%; the positive drug concentration is 0.25%. It is administered once a day at regular intervals for 5 consecutive days. Observation indicators and detection methods: 1. Body weight (BW) was measured at a fixed time before administration and on the 5th day after administration; 2. Food intake (FI) reduction method was measured, once a day; 3. Fasting blood g...

Example Embodiment

[0045] Example 3 Effect of tetrahydrocurcumin (THC) on rats with experimental metabolic syndrome

[0046] SD rats were adaptively fed for 7 days before experiment. 80 rats were randomly divided into 2 groups according to their body weights: 10 normal control groups and 70 models. The normal control group was filled with 4% Tween-80, and the model was filled with fat milk (formulation: lard 20%, cholesterol 4%, bile salt 1%, sugar 20%, table salt 8%, propylthiouracil 1%, vomiting Temperature -80 4%), intragastric volume 1ml / 100g·BW, qd. After 6 consecutive weeks, the rats were fasted for 16 hours, and the model was injected with STZ 30mg / kg (prepared with pH4.2, 0.1mol / L citric acid buffer, protected from light and ice bath, now prepared for current use), the normal group An equal volume of citrate buffer was injected intraperitoneally, with an injection volume of 0.5ml / 100g·BW. After injection of STZ, the model continued to be filled with fat emulsion until the end of the expe...

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Abstract

The invention provides application of tetrahydrocurcumin in preparing a medicament for preventing or/and treating a set of clinical syndromes which are characterized by aggregating a variety of metabolic disturbances in an individual, such as obesity, hypertension, abnormal blood fat, abnormal saccharometabolism, has specific medicinal effect, and is a new treatment medicament which can simultaneously and effectively correct a variety of clinical disturbance factors of MS clinically.

Description

technical field [0001] The present invention relates to a new application of tetrahydrocurcumin, in particular, an application in the preparation of medicines for preventing or / and treating metabolic syndrome. Background technique [0002] There is no unified and accepted definition of metabolic syndrome (Metabolic Syndrome, MS) in the world. It is generally believed that MS is caused by the combined effects of multiple genes and various environmental factors. Abnormal and central obesity as the main connotation, insulin resistance as the common pathological basis, and a group of clinical syndromes that seriously affect human health with the clinical characteristics of a variety of metabolic diseases. At present, about 1 / 4 to 1 / 3 of the adults in the world are affected by MS. With the aging of the population and the prevalence of overweight and obesity, its incidence and prevalence are increasing year by year. In the past 20 years, the prevalence of MS in the United States ...

Claims

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Application Information

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IPC IPC(8): A61K31/12A61P3/00A61P3/04A61P9/12A61P3/06A61P3/10
Inventor 赵军宁鄢良春
Owner SICHUAN ACAD OF CHINESE MEDICINE SCI
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