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Nasal thermosensitive in-situ gel prepared by radix scutellariae extract, its preparation method and its application

A technology of Scutellaria baicalensis extract and in-situ gel, which is applied in the direction of plant raw materials, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., which can solve the inconvenience of large-scale production of drugs, unsatisfactory preparations, complex ingredients, etc. problem, to achieve the effect of excellent drug effect, clear drug effect, and simple preparation method

Active Publication Date: 2012-02-15
四川乐嘉药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Composition is complex in Scutellaria baicalensis, and baicalin is only one of active ingredient wherein, when the content of baicalin is low, owing to wherein multiple composition comprises impurity existence, it is difficult to be prepared into preparation (as phospholipid complex); And adopt baicalin Pure product preparation, which is a compound with clear physical and chemical properties, is easy to prepare, but the content of baicalin in Scutellaria baicalensis is not less than 9.0%. "Chinese Pharmacopoeia" 2010 edition, the cost of extracting and separating pure baicalin is high, and it is not convenient for large-scale production of medicine , can not meet the needs of preparations

Method used

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  • Nasal thermosensitive in-situ gel prepared by radix scutellariae extract, its preparation method and its application
  • Nasal thermosensitive in-situ gel prepared by radix scutellariae extract, its preparation method and its application
  • Nasal thermosensitive in-situ gel prepared by radix scutellariae extract, its preparation method and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1 Preparation of Scutellaria baicalensis extract of the present invention

[0033] Take the Scutellaria baicalensis medicinal material, add water and decoct three times, 1 hour each time, combine the decoction, filter, concentrate the filtrate to an appropriate amount, add an appropriate amount of hydrochloric acid to adjust the pH value to 1.0-2.0, keep warm at 70°C, stand still, filter, and add an appropriate amount of precipitation Stir the water evenly, adjust the pH value to 7.0 with 40% sodium hydroxide solution, add an equal amount of ethanol, stir to dissolve, filter, adjust the pH value of the filtrate to 1.0-2.0 with hydrochloric acid, keep it warm at 70°C for 30 minutes, let it stand, and filter After that, the precipitate was washed with 47.5% ethanol until the pH value was 6.0-7.0, the ethanol was evaporated, and dried under reduced pressure to obtain the product.

[0034] The content of baicalin in the baicalin extract prepared by this method is...

Embodiment 2

[0035] Embodiment 2 Preparation of Scutellaria baicalensis extract phospholipid complex of the present invention

[0036] Weigh a certain amount of Scutellaria baicalensis extract and soybean lecithin with a PC content of 80 (weight ratio is 1:2, w / w), add absolute ethanol, the drug concentration of Scutellaria baicalensis extract is 5.0mg / ml, and keep the temperature at 55°C Stir magnetically at 120 rpm in a water bath for 2 hours, recover the solvent under reduced pressure, and dry in vacuum to obtain the phospholipid complex of Scutellaria baicalensis extract.

Embodiment 3

[0037] Example 3 Scutellaria baicalensis extract phospholipid complex preparation process experiment

[0038] For the preparation process, see figure 1

[0039] 1 single factor investigation

[0040] 1.1 Selection of reaction solvent

[0041] The PC content of soybean lecithin is 80, the reaction temperature is 50°C, the magnetic stirring speed is 120 rpm, the magnetic stirring time is 2h, the reaction concentration is 5mg / ml, and the weight ratio of Scutellaria baicalensis extract and phospholipid is 1:2. For phospholipid complexes, investigate the effects of tetrahydrofuran, absolute ethanol, petroleum ether (30-60): absolute ethanol (7:3), and dehydrated absolute ethanol as reaction solvents on the complex reaction, and evaluate the binding rate of phospholipid complexes Index, to investigate the effect of the reaction solvent on the preparation of the Scutellaria baicalensis extract phospholipid complex.

[0042] The investigation of different reaction solvents in table ...

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PUM

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Abstract

The invention provides a nasal thermosensitive in-situ gel prepared by a radix scutellariae extract. The invention also provides a preparation method and an application of the nasal thermosensitive in-situ gel prepared by the radix scutellariae extract. The invention also provides a phospholipid compound submicron emulsion prepared by the radix scutellariae extract. The in-situ gel has the advantages of obvious drug effect, strong controllability, safety and stability. A radix scutellariae phospholipid compound is suitable for drug administration in a nasal cavity, the drug effect is obvious which has better drug effect than that of a scutelloside pure product, the preparation method is simple and is convenient for large production, the drug effect of the radix scutellariae extract can be better exerted by using two preparation forms of the nasal thermosensitive in-situ gel and the submicron emulsion.

Description

technical field [0001] The invention relates to a temperature-sensitive in-situ gel for nasal use of Scutellaria baicalensis extract. Background technique [0002] Scutellaria baicalensis (Radix Scutellariae) is the dried root of Scutellaria baicalensis Georgi (Lamiaceae), a plant of the Labiatae family. It is widely distributed in my country, including Heilongjiang, Jilin, Liaoning, Henan, Hebei, Shandong, Sichuan, Yunnan, Shanxi, Shaanxi, Gansu and Inner Mongolia. And other provinces are the place of origin. Functions and indications: heat-clearing and damp-drying, purging fire and detoxification, hemostasis, anti-abortion. For damp heat, summer heat, chest tightness and nausea, damp heat and fullness, dysentery, jaundice, cough due to lung heat, high fever and polydipsia, vomiting of blood heat at the nose, carbuncle sores, restless fetal movement. Scutellaria baicalensis has anti-inflammatory, anti-allergic, anti-microbial, antipyretic, hypotensive, diuretic, blood lipi...

Claims

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Application Information

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IPC IPC(8): A61K36/539A61K9/00A61K47/34A61K47/48A61P9/10A61K125/00
Inventor 杨小容杨胜史亚军吴品江许润春林彦君王达宾
Owner 四川乐嘉药业有限公司
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