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Scheme for avoiding organ transplantation rejection

An organ and program technology, applied in the field of organ transplantation, can solve problems such as immune rejection and achieve the effect of sufficient organ sources

Inactive Publication Date: 2012-04-04
黄必录
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because these pancreases contain some mouse cellular components, transplantation to organ recipients still causes immune rejection

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0013] The present invention will be further described in detail below in conjunction with the examples.

[0014] The plan to avoid organ transplant rejection includes: 1. Organ production: 1. Inject human somatic cell-transformed ips or cloned ES into weak antigen pig blastocysts; 2. Transform human somatic cell-transformed ips or cloned ES ES injection into blastocysts of ordinary pigs; 3. Inject ips or cloned ES transformed from somatic cells of organ recipients into blastocysts of weak antigen pigs; 4. Transform ips or clones from somatic cells of organ recipients ES injection into blastocysts of ordinary pigs; 5. Injecting ips or cloned ES transformed from human somatic cells into blastocysts of organ-deficient pigs; 6. Injecting ips or cloned ES transformed from somatic cells of organ recipients into organs In blastocysts of pigs with deletion; 7. Pigs with weak antigen deficiency or organ deficiency pigs are further transformed into pigs hereinafter referred to as "weak...

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Abstract

The invention discloses a scheme for avoiding organ transplantation rejection. The scheme comprises the following steps of: injecting body cell-transformed ips (induced pluripotent stem) cells of an organ receiver or cloned ES (Embryonic Stem) cells into the blastula of a pig, developing in the uterus of the pig, giving birth and feeding to an age for utilizing; or directly using a homologous or heterogeneous organ; and transplanting the organ and stem cells in sequence, and gradually reducing the dosage of an immunologic suppression medicament, wherein alien cells can be eliminated gradually under the immune action of a human body and are filled by cells of the receiver till all the alien cells in the organ are replaced by the cells of the organ receiver. The scheme has the advantages of sufficient organ source, perpetual freeness from rejection after successful transplanting, and no need of taking any immunologic suppression medicament perpetually.

Description

technical field [0001] The invention relates to the field of organ transplantation, in particular to a scheme for avoiding rejection of organ transplantation. Background technique [0002] Diabetes, uremia, aging and other diseases due to degeneration or damage of organ or tissue function can save the life of the patient by transplanting the corresponding organ (or tissue). However, due to the severe shortage of organ sources and immune rejection ( With the exception of identical twins), a large number of precious lives are lost globally each year. [0003] Transplanting animal organs into humans can solve the problem of insufficient organ sources. The ideal animal is a pig, but to transplant pig organs to humans, the pig genome must first be modified so that the human immune system will not reject the pig organs, that is, the pig (organ provider) genome will contain The gene that causes human (organ recipient) immune rejection is "knocked out" and inserted into the human ...

Claims

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Application Information

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IPC IPC(8): A61F2/02
Inventor 黄必录
Owner 黄必录
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