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Compound bergamot oil nano-emulsion composition and preparation method thereof

A technology of bergamot oil and nanoemulsion, which is applied in the field of medicine and achieves the effects of good dispersion, high content of active ingredients and high bioavailability

Inactive Publication Date: 2012-04-04
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Antibacterial drugs play a pivotal role in the control of human infectious diseases. At present, the clinically used antibacterial drugs mainly include western medicine, but with their widespread use, the problem of bacterial drug resistance has become a problem that cannot be ignored

Method used

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  • Compound bergamot oil nano-emulsion composition and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] 1) Weigh 29.2g of RH-40, 4.1g of absolute ethanol, 7.5g of bergamot oil, 2.2g of patchouli oil, 2.0g of tea tree oil, 0.8g of peppermint oil, and 54.2g of distilled water, and set aside;

[0073] 2) Stir bergamot oil, patchouli oil, tea tree oil and peppermint oil well as the oil phase;

[0074] 3) Add RH-40 and absolute ethanol to the oil phase and mix well;

[0075] 4) Use distilled water as the water phase, stir the oil phase quickly at room temperature, slowly add the water phase dropwise while stirring, and keep stirring until the system becomes a transparent liquid, and the compound bergamot oil nanoemulsion composition is obtained.

Embodiment 2

[0077] Consists of 28.9g of RH-40, 4.2g of 1,2-propanediol, 8.3g of bergamot oil, 1.8g of patchouli oil, 1.6g of tea tree oil, 0.7g of peppermint oil, and 54.5g of distilled water.

Embodiment 3

[0079] It consists of 30.5g of EL-40, 2.7g of absolute ethanol, 5.8g of bergamot oil, 1.6g of patchouli oil, 1.9g of tea tree oil, 0.4g of peppermint oil, and 57.1g of distilled water.

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Abstract

The invention discloses a compound bergamot oil nano-emulsion composition, which is characterized in that: the granularity of the nano-emulsion is 1nm to 100nm, and comprises the following substances by weight mass: 23 to 35 percent of surface active agent, 0.3 to 8 percent of cosurfacant, 1.5 to 10 percent of bergamot oil, 0.5 to 5.5 percent of patchouli, 0.4 to 4.5 percent of tea tree oil, 0.3 to 2.2 percent of pennyroyal and distilled water, wherein the sum of the mass percentage of the ingredients is 100 percent. The compound bergamot oil nano-emulsion composition is broad-spectrum antimicrobic, has good treatment effect on eczema, psoriasis, herpes, dermatitis, blain, wound, acne, urinary infection and the like, the permeability is strong, the stability is good, content of active ingredients is high, transdermal absorption effect is remarkable, action time is durable, the preparation method is simple and is easy to popularize and use, and the medicine has vast application prospect on the medical market.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a compound bergamot oil nanoemulsion composition for treating eczema, psoriasis, dermatitis, pustule, wound, acne and urinary tract infection and a preparation method thereof. Background technique [0002] Antibacterial drugs play a pivotal role in the control of human infectious diseases. At present, the clinically used antibacterial drugs mainly include western medicines, but with their widespread use, the problem of bacterial drug resistance has become a problem that cannot be ignored. Due to the relative lag in the development of new drugs, human beings are facing an "antibacterial drug crisis". Plants are the natural treasure house of biologically active compounds. Natural products with antibacterial activity have become the focus of people's attention because of their low adverse reactions, safety and no side effects. Contents of the invention [0003] For the problems and defects ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/82A61K9/107A61P17/00A61P17/02A61P17/10
Inventor 欧阳五庆郑星星郭建军
Owner NORTHWEST A & F UNIV
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