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Lipid bilayer sensor array

A technology of sensor elements and sensor devices, which is applied in the direction of instruments, scientific instruments, material inspection products, etc., can solve problems affecting costs, etc., and achieve the effect of uniform efficiency and improved efficiency

Active Publication Date: 2012-04-04
OXFORD NANOPORE TECH LTD
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Problems solved by technology

However, these limitations affect the cost of the technology

Method used

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  • Lipid bilayer sensor array
  • Lipid bilayer sensor array
  • Lipid bilayer sensor array

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Embodiment Construction

[0043] A device 1 for sensing the interaction of molecular entities with membrane proteins inserted in lipid bilayers will first be described, schematically in figure 1 shown in . The device 1 comprises sensor means 2 connected to a detection circuit 3 which in turn is detected to a data processor 4 .

[0044] The sensor arrangement 2 is an apparatus as described in detail in International Patent Application No. PCT / GB08 / 004127, which is incorporated herein by reference. Without being limited to the general teachings there, the sensor device 2 has features such as figure 2 The structure shown in cross-section of , comprises a body 20 in which a plurality of wells 21 are formed, each well being a recess having a well electrode 22 disposed therein. A large number of wells 21 are provided to optimize the data collection rate of the device 1 . In general, there may be any number of wells 21, typically 256 or 1024, although only some of the wells 21 are shown in figure 2 midd...

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Abstract

An apparatus for sensing of an interaction of a molecular entity with a membrane protein in a lipid bilayer comprises an array of sensor elements (21) arranged to output an electrical signal that is dependant on occurrences of the interaction. A detection circuit (3) comprised detection channels (30) capable of amplifying an electrical signal from a sensor element. More sensor elements (21) are provided than detection channels (30), and detection channels (30) are selectively connected to sensor elements (21) that have acceptable quality of performance in that a lipid bilayer is formed and that an acceptable number of membrane proteins are inserted, on the basis of the amplified electrical signals that are output from the detection channels. This improves the efficiency of utilisation of the detection channels, due to inefficiency in the utilisation of the sensor elements, resulting in a reduction in the cost of the apparatus and the ability to perform sensing using relatively small samples.

Description

technical field [0001] The present invention relates to the detection of physical phenomena using sensor elements. Aspects of the invention find particular application in the detection of stochastic physical events, such as events involving the interaction of molecular entities with, for example, membrane proteins inserted in lipid bilayers. Background technique [0002] For the sensing of molecular entities, the use of membrane proteins inserted in lipid bilayers has been disclosed. Interactions of molecular entities with membrane proteins can modulate electrical signals that appear to pass through lipid bilayers, such as regulating ionic currents flowing through membrane proteins that act as protein pores. Thus, the interaction of molecular entities with membrane proteins can be sensed by monitoring the electrical signals that appear to cross the lipid bilayer to detect changes characteristic of regulation. Many techniques have been proposed based on this principle, one ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/487
CPCG01N27/3272G01N33/53G01N33/48728G01N33/92
Inventor 安东尼奥·卡纳斯西蒙·阿德里安·韦尔斯
Owner OXFORD NANOPORE TECH LTD
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