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New use of total glucosides of paeony and medicinal composition thereof

A technology of total glucosides of paeony and its composition, applied in the field of new uses of total glucosides of paeony and its pharmaceutical composition, to achieve the effects of increasing serum DA content, improving intestinal sensitivity, and inhibiting abdominal pain

Active Publication Date: 2012-04-18
成都中医大中医药健康产业技术研究院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, there is no report on the use of total glucosides of paeony for the treatment of irritable bowel syndrome

Method used

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  • New use of total glucosides of paeony and medicinal composition thereof
  • New use of total glucosides of paeony and medicinal composition thereof
  • New use of total glucosides of paeony and medicinal composition thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Example 1 Preparation of Total Glycosides of Paeony

[0041] Take the coarse powder of Radix Paeoniae Alba, use 70% V / V ethanol as the extraction solvent, the solvent dosage is 8 times the amount w / v, reflux extraction for 1.5h, and extract 3 times in total. Filtrate, combine the filtrates, concentrate under reduced pressure until there is no alcohol smell, add an appropriate amount of water to dissolve, centrifuge, take the supernatant, adjust its concentration to 1g / ml (containing 1g of Radix Paeoniae Alba in every 1ml of the medicinal solution), and the medicinal solution passes through a diameter of 1g. AB-8 macroporous adsorption resin column with a ratio of 1:20 (the volume ratio of medicinal solution to macroporous absorbent resin is 1:2). After the medicinal solution is adsorbed on the resin column for 30 minutes, wash away impurities with 4BV distilled water and collect 6BV60% V / V ethanol eluent, the flow rate is 3BV / h, the ethanol is recovered under reduced pr...

Embodiment 2

[0045] The preparation method of embodiment 2 total saponins of Glycyrrhizae

[0046] (1) Take licorice coarse powder, percolate with 20 times the amount of 95% ethanol, filter the percolate, concentrate under reduced pressure at 70°C to form a thick paste, stir and dissolve with heated water, and then use petroleum ether, ethyl acetate, water Saturated n-butanol extraction, the part obtained from ethyl acetate is the total flavonoids, and the n-butanol extract is used for later use.

[0047] (2) Take the filter residue obtained in step (1), percolate with 20 times the amount of 20% V / V ethanol, after the percolation liquid is filtered, the extract is concentrated under reduced pressure at 60-70°C until it has no alcohol smell, and then saturated with n-butyl Alcohol extraction, the obtained extract is combined with the n-butanol extract obtained in step (1), after the n-butanol is recovered under reduced pressure, the residue is dissolved in water, centrifuged, the supernatan...

Embodiment 3

[0051] Embodiment 3 Preparation of the pharmaceutical composition of the present invention

[0052] Take 100 g of total glucosides of paeony prepared in Example 1 and 300 g of total saponins of glycyrrhizin prepared in Example 2, add appropriate amount of microcrystalline cellulose, mix well, pack into capsules, and obtain.

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Abstract

The invention discloses a use of total glucosides of paeony in the preparation of a medicine for treating irritable bowel syndrome. The invention also discloses a medicinal composition and use thereof. In the invention, by changing sensitivity of intestines, total glucosides of paeony and a mixture of total glucosides of paeony and total glucosides of liquoric root can reduce frequency, spike potential, peak to peak value and peak area of colon, reduce the raised CCK content in blood plasma, increase lowered GAS content in blood plasma, obviously improve low DA content in serum of patients and increase increased mastocytes in colon, thereby achieving obvious treatment effect in treatment of irritable bowel syndrome. Meanwhile, by combining total glucosides of paeony and total glucosides of liquoric root, obvious medicine effect can be achieved with a small dosage; and the total glucosides of paeony and total glucosides of liquoric root can be used for treating irritable bowel syndrome. The total glucosides of paeony and a mixture of total glucosides of paeony and total glucosides of liquoric root can inhibit stomachache caused by irritable bowel syndrome and improve colon function disorder phenomenon, and provides a new choice for clinic medicine administration.

Description

technical field [0001] The invention relates to a new application of total glucosides of paeony and its pharmaceutical composition. Belongs to the field of medicine. Background technique [0002] Irritable bowel syndrome (Irritable Bowel Syndrome, IBS) was first reported by Powell in 1820. The syndrome without abnormal morphological and biochemical changes is one of the most common functional gastrointestinal diseases in clinical practice. At present, the diagnosis of IBS is mainly based on symptomology and based on the exclusion of organic diseases. In recent years, many studies have shown that gastrointestinal motility disorder and visceral abnormality are the main pathophysiological basis of the symptoms of this disease, and its pathogenesis is obviously affected by psychosocial factors. Research reports from various places show that IBS is a common and frequently-occurring disease worldwide, and its incidence rate is quite high. According to epidemiological surveys, ...

Claims

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Application Information

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IPC IPC(8): A61K36/71A61P1/00
Inventor 彭成李瑜朱力阳郭力
Owner 成都中医大中医药健康产业技术研究院有限公司