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Novel application of licorice total saponin

A technology of total saponins and licorice, applied in the new application field of licorice total saponins, to achieve the effects of increasing serum DA content, improving intestinal sensitivity and inhibiting abdominal pain

Inactive Publication Date: 2012-04-18
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, there is no report on the treatment of irritable bowel syndrome with total glycyrrhizin only.

Method used

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  • Novel application of licorice total saponin
  • Novel application of licorice total saponin
  • Novel application of licorice total saponin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The preparation method of embodiment 1 total saponins of Glycyrrhizae

[0024] (1) Take licorice coarse powder, percolate with 20 times the amount of 95% ethanol, filter the percolate, concentrate under reduced pressure at 70°C to form a thick paste, stir and dissolve with heated water, and then use petroleum ether, ethyl acetate, water Saturated n-butanol extraction, the part obtained from ethyl acetate is the total flavonoids, and the n-butanol extract is used for later use.

[0025] (2) Take the filter residue obtained in step (1), percolate with 20 times the amount of 20% V / V ethanol, and after the percolation liquid is filtered, the extract is concentrated under reduced pressure at 60-70°C until it has no alcohol smell, and then saturated with n-butyl alcohol Alcohol extraction, the obtained extract is combined with the n-butanol extract obtained in step (1), after the n-butanol is recovered under reduced pressure, the residue is dissolved in water, centrifuged, th...

experiment example 1

[0030] Experimental example 1 Experimental study on the treatment of glacial acetic acid visceral hypersensitivity IBS disease model with total licorice saponins

[0031] 1.1 Materials and methods

[0032] 1.1.1 Drugs

[0033] 1.1.1.1 Test drug: total glycyrrhizin (prepared in Example 1).

[0034] 1.1.1.2 Positive drug: Trimebutin Tablets, produced by Tianjin Tanabe Pharmaceutical Co., Ltd., production batch number: 0905005, specification: 0.1g / tablet×20 tablets / box. During the experiment, distilled water was used to prepare a medicinal solution with a concentration of 2% (containing 0.02 g of trimebutin per milliliter) for subsequent use.

[0035] 1.1.1.3 Main reagents: 0.5% glacial acetic acid (volume fraction), 1.5% sodium pentobarbital, normal saline, liquid paraffin.

[0036] 1.1.2 Animals

[0037] SD rats, both male and female, weighing 200±20g, were provided by the Experimental Animal Research Center of Chengdu University of Traditional Chinese Medicine, license num...

experiment example 2

[0055] Experimental example 2 Experimental study on the treatment of mustard oil visceral hypersensitivity IBS disease model by total licorice saponins

[0056] 1.1 Materials and methods

[0057] 1.1.1 Drugs

[0058] 1.1.1.1 Test drug: total glycyrrhizin (prepared in Example 1).

[0059] 1.1.1.2 Positive drug: Trimebutin Tablets, produced by Tianjin Tanabe Pharmaceutical Co., Ltd., production batch number: 0905005, specification: 0.1g / tablet×20 tablets / box. During the experiment, distilled water was used to prepare a medicinal solution with a concentration of 2% (containing 0.02 g of trimebutin per milliliter) for subsequent use.

[0060] 1.1.1.3 Main reagents: 5% mustard oil (volume fraction), 1.5% sodium pentobarbital, normal saline, liquid paraffin.

[0061] 1.1.1.4 Animals

[0062] SD rats, both male and female, weighing 200±20g, were provided by the Experimental Animal Research Center of Chengdu University of Traditional Chinese Medicine, license number: 04-11, and we...

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Abstract

The invention provides an application of licorice total saponin in the preparation of medicines used for treating irritable bowel syndrome (IBS). With licorice total saponin, enteric sensitivity can be ameliorated; frequency, peak potential, peak value and peak area of colon can be reduced; increased CCK content in blood plasma can be reduced; reduced GAS content in blood serum can be increased; low-level blood serum DA content of a patient can be substantially increased; and an increased mast cell number in colon can be reduced. Therefore, licorice total saponin shows a substantial curative effect during the treatment of IBS. With licorice total saponin, stomachache caused by IBS can be inhibited, a phenomenon of colon functional disorder can be ameliorated, and a novel selection is provided for clinical medication.

Description

technical field [0001] The invention relates to a new application of total glycyrrhizin saponins. Belongs to the field of medicine. Background technique [0002] Irritable bowel syndrome (Irritable Bowel Syndrome, IBS) was first reported by Powell in 1820. The syndrome without abnormal morphological and biochemical changes is one of the most common functional gastrointestinal diseases in clinical practice. At present, the diagnosis of IBS is mainly based on symptomology and based on the exclusion of organic diseases. In recent years, many studies have shown that gastrointestinal motility disorder and visceral abnormality are the main pathophysiological basis of the symptoms of this disease, and its pathogenesis is obviously affected by psychosocial factors. Research reports from various places show that IBS is a common and frequently-occurring disease worldwide, and its incidence rate is quite high. According to epidemiological surveys, the prevalence rate in Western cou...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/484A61P1/00
Inventor 彭成李瑜朱力阳郭力
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE