Azithromycin enteric capsules

A technology of azithromycin and enteric-coated capsules, which is applied in the field of preparation of pharmaceutical preparations and can solve problems such as stability changes

Active Publication Date: 2012-04-25
珠海润都制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Although the acid resistance of azithromycin has been greatly improved compared with erythromycin, it has been found through a large number of experimental studies that the stability of azithromycin still changes to a certain extent under the condition of lower pH value.

Method used

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  • Azithromycin enteric capsules
  • Azithromycin enteric capsules
  • Azithromycin enteric capsules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0076] Wherein said vegetarian pill prescription is as follows:

[0077]

[0078] Wherein said isolation layer coated pellet prescription is as follows:

[0079]

[0080] Wherein said enteric coating layer coating pellet prescription is as follows:

[0081]

[0082]

[0083] The preparation method is as follows:

[0084] 1) Raw and auxiliary materials are crushed and sieved

[0085] Azithromycin was pulverized on a pulverizer and passed through an 80-mesh sieve; microcrystalline cellulose, lactose, and sodium carboxymethyl starch were passed through an 80-mesh sieve on a vibrating sieve. Weigh raw materials and excipients according to the prescription.

[0086] 2) Wet mixing granulation

[0087] Put the weighed azithromycin and other ingredients in the prescription of vegetarian pills into the wet granulator in sequence, mix at a low speed for 300 seconds, then add the prescribed amount of purified water, finish adding within 90 seconds, continue to stir for 30...

Embodiment 2

[0106]

[0107]

[0108] Preparation method is the same as embodiment 1

Embodiment 3

[0110]

[0111] The preparation method is the same as in Example 1.

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Abstract

The present invention relates to azithromycin enteric capsulea, which comprises the following components:

Description

Technical field: [0001] The invention relates to the preparation of a pharmaceutical preparation, in particular to an azithromycin enteric-coated capsule and its preparation. Background technique: [0002] Enteric-coated preparations: refer to the enteric-coated preparations in which the orally administered drugs are not released or hardly released in the specified acidic medium, but most or all of them are released in the pH6.8 phosphate buffer solution within the required time, and include A colon-localized enteric-coated preparation that does not release or hardly releases in the specified acidic medium and pH 6.8 phosphate buffer, but releases most or all of it in the pH 7.5-8.0 phosphate buffer within the required time . [0003] Azithromycin is an azalide antibiotic. Its mechanism of action is to interfere with the synthesis of proteins (without affecting the synthesis of nucleic acids) by binding to the subunit of the 50s ribosome of sensitive microorganisms. Its c...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K31/7052A61K47/38A61P31/04
Inventor 陈新民莫泽艺周佳张志刚王博
Owner 珠海润都制药股份有限公司
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