Iron-dextrin long-acting injection and preparation method thereof

A technology of iron dextran and dextran, which is applied in the field of long-acting iron supplement injection and its preparation, can solve the problems of unstable drug release, unfavorable growth of piglets, waste of manpower and material resources, etc., achieve stable blood drug concentration, avoid peak and valley phenomena, Effects of total dose reduction

Inactive Publication Date: 2012-05-09
TIANJIN RINGPU BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this method can effectively prevent iron deficiency symptoms in piglets, such iron injections on the market generally have high injection stress, and the drug is not released smoothly in the body. After the basic metabolism is completed, iron deficiency symptoms will appear again. Therefore, re-injection is often required to ensure the iron requirement in the body. This will not only cause waste, but also cause injection stress to piglets after multiple injections, which is not conducive to the growth of piglets. waste of manpower and material resources

Method used

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  • Iron-dextrin long-acting injection and preparation method thereof
  • Iron-dextrin long-acting injection and preparation method thereof
  • Iron-dextrin long-acting injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The prescription of iron dextran long-acting injection:

[0022] Component Dosage

[0023] Iron Dextran Superfine Powder 10.0kg

[0024] Tween-80 1.0kg

[0025] Aluminum stearate 2.0kg

[0026] VE oil 1.0kg

[0027] Benzyl alcohol 1.0kg

[0028] Soybean oil for injection to 100L

[0029] The preparation method of iron dextran long-acting injection:

[0030] (1) Measure 95L of soybean oil for injection, add aluminum stearate, heat to dissolve the suspending agent to form a transparent polymer gel system, and obtain liquid A.

[0031] (2) Take about 80 LA liquid and add Tween-80 and VE oil in sequence, after grinding evenly, add iron dextran superfine powder, and stir to obtain solution B.

[0032] (3) Add benzyl alcohol to solution B and mix evenly, and dilute to 100L with the remaining solution A to obtain solution C.

[0033] (4) The solution C is dispersed and micronized by a high-pressure homogenizer, and an appropriate pressure is selected to ensure the part...

Embodiment 2

[0036] The prescription of iron dextran long-acting injection:

[0037] Component Dosage

[0038] Iron Dextran Superfine Powder 20.0kg

[0039] Macrogol 400 2.0% kg

[0040] Aluminum stearate 2.0% kg

[0041] Thiourea 1.0% kg

[0042] Procaine hydrochloride 3.0% kg

[0043] Ethyl oleate make up to 100L

[0044] The preparation method of iron dextran long-acting injection:

[0045] (1) Measure 95L of soybean oil for injection, add aluminum stearate, heat to dissolve the suspending agent to form a transparent polymer gel system, and obtain liquid A.

[0046] (2) Take 80LA liquid and add polyethylene glycol 400 and VE oil successively, after grinding evenly, add iron dextran superfine powder, and stir to obtain solution B.

[0047] (3) Add solution B to benzyl alcohol and mix evenly, and use the remaining solution A to make up to 100L to obtain solution C.

[0048] (4) The solution C is dispersed and micronized by a high-pressure homogenizer, and an appropriate pressure i...

Embodiment 3

[0051] The prescription of iron dextran long-acting injection:

[0052] Component Dosage

[0053] Iron Dextran Superfine Powder 30.0kg

[0054] Tween-80 5.0kg

[0055] Aluminum stearate 2.5kg

[0056] Propyl gallate 1.0kg

[0057] Lidocaine Hydrochloride 5.0kg

[0058] Soybean oil for injection to 100L

[0059] The preparation method of iron dextran long-acting injection:

[0060] (1) Measure 90L of soybean oil for injection, add aluminum stearate, heat to dissolve the suspending agent to form a transparent polymer gel system, and obtain liquid A.

[0061] (2) Take 75LA liquid, add Tween-80 and VE oil in turn, grind evenly, then add iron dextran superfine powder, and stir to obtain solution B.

[0062] (3) Add benzyl alcohol to solution B and mix evenly, and dilute to 100L with the remaining solution A to obtain solution C.

[0063] (4) The solution C is dispersed and micronized by a high-pressure homogenizer, and an appropriate pressure is selected to ensure the particl...

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PUM

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Abstract

The invention relates to iron-dextrin long-acting injection and a preparation method thereof. The iron-dextrin long-acting injection is used for piglet iron supplement iron, and has the advantages that the release, absorption, distribution, metabolism and excretion processes of an iron preparation can be prolonged in vivo, so that the purpose of prolonging the action of a drug can be achieved, the number of the dosing times can be reduced, the complicance of livestocks is improved, the blood concentration can be stable, the peak and valley phenomena can be avoided, the side effects of the drug can be facilitated to be reduced, the total drug dosage is reduced, and further, the maximum drug effect by the minimum dosage is achieved. Thus, the iron-dextrin long-acting injection can completely play the role of long-acting iron supplement in the prevention and the cure of piglet iron-deficiency anemia.

Description

technical field [0001] The invention belongs to the field of veterinary drugs, in particular to a long-acting iron supplement injection used for preventing and treating piglet iron deficiency anemia and a preparation method thereof. Background technique [0002] Iron is an essential trace element for the growth and development of suckling piglets, and is a component of various enzymes in the body. Newborn piglets have the least amount of iron in their bodies, requiring 15 mg of iron per day, and up to 1 mg of iron can be obtained in breast milk per day. Therefore, the iron stored in the piglet will soon be depleted, and if it is not replenished in time, anemia may occur. Iron deficiency anemia in piglets can occur throughout the year, but it occurs more in winter and spring than in other seasons. In general closed feeding, the disease is more common in suckling piglets within 1 month of age (especially within 2 weeks to 3 weeks). Piglets suffering from anemia have decreas...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/10A61K31/721A61K47/44A61K47/34A61K47/32A61K47/22A61K47/20A61K47/16A61K47/14A61P7/06A61P3/02
Inventor 聂丽娜王爱萍夏雪林刘桂兰
Owner TIANJIN RINGPU BIO TECH
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