Iron-dextrin long-acting injection and preparation method thereof
A technology of iron dextran and dextran, which is applied in the field of long-acting iron supplement injection and its preparation, can solve the problems of unstable drug release, unfavorable growth of piglets, waste of manpower and material resources, etc., achieve stable blood drug concentration, avoid peak and valley phenomena, Effects of total dose reduction
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Embodiment 1
[0021] The prescription of iron dextran long-acting injection:
[0022] Component Dosage
[0023] Iron Dextran Superfine Powder 10.0kg
[0024] Tween-80 1.0kg
[0025] Aluminum stearate 2.0kg
[0026] VE oil 1.0kg
[0027] Benzyl alcohol 1.0kg
[0028] Soybean oil for injection to 100L
[0029] The preparation method of iron dextran long-acting injection:
[0030] (1) Measure 95L of soybean oil for injection, add aluminum stearate, heat to dissolve the suspending agent to form a transparent polymer gel system, and obtain liquid A.
[0031] (2) Take about 80 LA liquid and add Tween-80 and VE oil in sequence, after grinding evenly, add iron dextran superfine powder, and stir to obtain solution B.
[0032] (3) Add benzyl alcohol to solution B and mix evenly, and dilute to 100L with the remaining solution A to obtain solution C.
[0033] (4) The solution C is dispersed and micronized by a high-pressure homogenizer, and an appropriate pressure is selected to ensure the part...
Embodiment 2
[0036] The prescription of iron dextran long-acting injection:
[0037] Component Dosage
[0038] Iron Dextran Superfine Powder 20.0kg
[0039] Macrogol 400 2.0% kg
[0040] Aluminum stearate 2.0% kg
[0041] Thiourea 1.0% kg
[0042] Procaine hydrochloride 3.0% kg
[0043] Ethyl oleate make up to 100L
[0044] The preparation method of iron dextran long-acting injection:
[0045] (1) Measure 95L of soybean oil for injection, add aluminum stearate, heat to dissolve the suspending agent to form a transparent polymer gel system, and obtain liquid A.
[0046] (2) Take 80LA liquid and add polyethylene glycol 400 and VE oil successively, after grinding evenly, add iron dextran superfine powder, and stir to obtain solution B.
[0047] (3) Add solution B to benzyl alcohol and mix evenly, and use the remaining solution A to make up to 100L to obtain solution C.
[0048] (4) The solution C is dispersed and micronized by a high-pressure homogenizer, and an appropriate pressure i...
Embodiment 3
[0051] The prescription of iron dextran long-acting injection:
[0052] Component Dosage
[0053] Iron Dextran Superfine Powder 30.0kg
[0054] Tween-80 5.0kg
[0055] Aluminum stearate 2.5kg
[0056] Propyl gallate 1.0kg
[0057] Lidocaine Hydrochloride 5.0kg
[0058] Soybean oil for injection to 100L
[0059] The preparation method of iron dextran long-acting injection:
[0060] (1) Measure 90L of soybean oil for injection, add aluminum stearate, heat to dissolve the suspending agent to form a transparent polymer gel system, and obtain liquid A.
[0061] (2) Take 75LA liquid, add Tween-80 and VE oil in turn, grind evenly, then add iron dextran superfine powder, and stir to obtain solution B.
[0062] (3) Add benzyl alcohol to solution B and mix evenly, and dilute to 100L with the remaining solution A to obtain solution C.
[0063] (4) The solution C is dispersed and micronized by a high-pressure homogenizer, and an appropriate pressure is selected to ensure the particl...
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