Cholesterol hybrid compound of molybdenum-containing polyoxometallate and preparation method of cholesterol hybrid compound

A technology of polyoxometalate and cholesterol, applied in steroids, organic chemistry and other directions, can solve the problems of destruction, toxicity and harm, and achieve the effects of simple purification, simple and easy preparation method and high yield

Inactive Publication Date: 2012-05-09
NANKAI UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This therapy is sometimes called "cytotoxic therapy" because the drugs used are harmful, even toxic, and the cells in the body, whether malignant or not, are destroyed, and even some anticancer drugs are not easily absorbed by specific cells

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  • Cholesterol hybrid compound of molybdenum-containing polyoxometallate and preparation method of cholesterol hybrid compound
  • Cholesterol hybrid compound of molybdenum-containing polyoxometallate and preparation method of cholesterol hybrid compound
  • Cholesterol hybrid compound of molybdenum-containing polyoxometallate and preparation method of cholesterol hybrid compound

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Embodiment

[0027] Embodiment: prepare the cholesterol hybrid compound containing molybdenum polyoxometalate, the steps are as follows:

[0028] 1) Under argon protection, mix 1.5g of cholesterol, 95mg of 4-dimethylaminopyridine, 776mg of succinic anhydride and 614mg of pyridine in 75mL of dichloromethane solvent, slowly heat up to 40°C under stirring, and reflux the solution for 72 hours, then The reaction solution was lowered to room temperature, spin-dried, and the solid was dissolved in 50 mL of chloroform, extracted three times with deionized water, and the separated organic phase was dried with anhydrous magnesium sulfate, concentrated, precipitated in 400 mL of ethanol, filtered out the product, and vacuum After drying, a white solid is obtained, which is cholesterol succinic acid monoester;

[0029] 2) With 164 mg of 2-ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline and 82 mL of acetonitrile solvent, under reflux conditions, add 215 mg of cholesterol succinic acid monoester, react fo...

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Abstract

The invention discloses a cholesterol hybrid compound of molybdenum-containing polyoxometallate, comprising a chemical formula of [(n-Bu)4N]3{MnMo6O18[(OCH2)3CNHCOC30H49O2]2}. The invention further discloses a preparation method of the cholesterol hybrid compound, which comprises the following steps of: with cholesterol as starting materials, reacting the cholesterol with succinic anhydride to obtain cholesteryl hemisuccinate; and reacting the molybdenum-containing polyoxometallate with an Anderson structure with the cholesteryl hemisuccinate to obtain hybrid compounds which are bonded by covalent bonds. The invention has the advantages that: by adopting an organic-inorganic hybridization method, chemical modification is carried out on the molybdenum-containing polyoxometallate, so that the molybdenum-containing polyoxometallate is bonded with the cholesterol by covalent bonds for the first time; moreover; the preparation method provided by the invention has the advantages of convenience and feasibility in operation, simpleness in purification, higher productivity and convenience for popularization and application; and the hybrid compound provided by the invention has potential application values on medicine, biology, catalyst, surfactant and the like.

Description

technical field [0001] The invention relates to the synthesis technology of organic-inorganic hybrid macromolecular compounds, in particular to a cholesterol hybrid compound containing molybdenum polyoxometalates and a preparation method thereof. Background technique [0002] Cancer has always been a serious threat to human health. The current environmental pollution is increasing day by day, the living environment of human beings is deteriorating, and the contact with carcinogenic factors is getting closer and closer, resulting in a rapid increase in the mortality rate of human beings caused by cancer. The current treatment methods for cancer generally include methods such as surgical treatment, radiotherapy and chemotherapy, but chemotherapy is still the main method at present. Chemotherapy is to bring drugs to the whole body through blood vessels, affecting all cells in the body. This therapy is sometimes called "cytotoxic therapy" because the drugs used are harmful, eve...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J9/00
Inventor 王维杨海宽肖雨李秋月夏楠
Owner NANKAI UNIV
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