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Preparation method and application of sustained-release system of anti-inflammatory medicament and growth factor

A growth factor and anti-inflammatory technology, applied in the field of biomedical materials, can solve the problems of loss of biological activity, inactivation, and failure to achieve biological effects, etc., and achieve the effects of increased drug release rate, large range, and simple process

Inactive Publication Date: 2012-05-30
DALIAN CHUANGDA TECH TRADE MARKET
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since growth factors are generally easy to lose their biological activity in the presence of water and at room temperature, the direct use of growth factors will often be inactivated due to the environment in the body, and the desired biological effect cannot be achieved.

Method used

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  • Preparation method and application of sustained-release system of anti-inflammatory medicament and growth factor
  • Preparation method and application of sustained-release system of anti-inflammatory medicament and growth factor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] 1) Dissolve PLGA and Meifuxian with a mass ratio of 100:1 in a mixed solvent of DMF / THF (1 / 1) to form an electrospinning solution, and the concentration of PLGA is 0.1g / mL;

[0033] 2) Electrospinning the prepared electrospinning solution, the control voltage is 15KV, the flow rate of the spinning solution is Sml / h, and a nanofiber film product with a fiber diameter of 80-800nm ​​is obtained;

[0034] 3) The obtained nanofiber film is used for postoperative tissue anti-adhesion, which can prevent inflammation and complications caused by local tissue adhesion.

Embodiment 2

[0036] 1) Dissolve PLLA and Mephicin with a mass ratio of 100:1 in a mixed solvent of DMF / =chloromethane (1 / 1.5) to form an electrospinning solution, wherein the concentration of PLLA is 0.1 g / mL;

[0037] 2) The obtained electrospinning solution is subjected to electrospinning, the control voltage is 30KV, the flow rate of the spinning solution is 15ml / h, and a nanofiber film product having a diameter of 100-1000nm is obtained;

[0038]3) The obtained nanofiber film is used for postoperative tissue anti-adhesion, which can prevent inflammation and complications caused by local tissue adhesion.

Embodiment 3

[0040] 1) Dissolve PLA-PEG and mephixen at a mass ratio of 50:1 in an acetone solution to prepare an electrospinning solution, in which the concentration of PLA-PEG is 0.2g / mL.

[0041] 2) Electrospinning is carried out with the obtained electrospinning solution, the control voltage is 10KV, and the flow rate of the spinning solution is 1ml / h to obtain a nanofiber film product with a diameter of 100-800nm;

[0042] 3) The obtained nanofiber film is used for postoperative tissue anti-adhesion to prevent inflammation and complications caused by local tissue adhesion.

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Abstract

The invention belongs to the technical field of biomedical materials, and particularly relates to a preparation method and an application of a sustained-release system of anti-inflammatory medicaments and growth factors; a nanofiber drug loaded film prepared by the method is applicable to postoperative adhesion prevention and inflammation resistance, and skin tissue engineering stents. As a postoperative adhesion preventing film, the product has biodegradability and good biocompatibility, and can prevent postoperative inflammatory response through the controlled release of anti-inflammatory medicaments; meanwhile, through the combination of the medicaments with growth factors, the product can be used in skin tissue engineering, not only prevents inflammatory response at affected sites, but also releases growth factors to promote the regeneration and healing of skin cells. The nanofiber drug loaded film preparation method has a simple process and good controllability, and has wide application prospects in the fields of postoperative adhesion prevention and inflammation resistance, as well as skin tissue engineering.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a drug and growth factor slow-release system for postoperative anti-adhesion or skin tissue repair, a preparation method and application thereof. Background technique [0002] Polymer materials and their composites have been widely used in modern medicine, and biodegradable and absorbable polymers are currently one of the ideal biomedical polymer materials. Electrospinning is a new technology that can easily and efficiently prepare nanofibers. It generates a jet flow by applying a high electric field to a polymer solution or solution. The jet is stretched while the solvent is volatilized to form fibers with a diameter of 3-5000nm. Electrospun fibers have achieved many applications in the field of functional materials, especially in the field of biomedicine, such as tissue engineering scaffolds, wound dressings, and surgical isolation membranes. In the f...

Claims

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Application Information

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IPC IPC(8): A61L31/04A61L31/06A61L31/16A61L31/14A61L27/14A61L27/22A61L27/18A61L27/24A61L27/16A61L27/20A61L27/54A61L27/60D01F1/10D01D1/02D01D5/00
Inventor 杜冲
Owner DALIAN CHUANGDA TECH TRADE MARKET
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