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A technology of anti-infective drugs and anthracene derivatives, applied in the field of anthracene derivatives as anti-infective drugs, can solve the problems of unknown effect and the like
Inactive Publication Date: 2012-05-30
SEALIFE PHARMA
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Although a parallel, simultaneously filed Austrian patent application with application number A 842 / 09 provides two new compounds, an altersolanol and an alterporriol derivative, the present invention relates to the use of various compounds, the structures of which are known from the literature , but its effect is so far unknown
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[0037] Hereinafter, the present invention is described in further detail with reference to specific exemplary embodiments, however, this is not meant to limit the scope of the present invention in any way.
[0038] Compounds of chemical formulas (4) to (8) are obtained by culturing Puccinia glomerulus to obtain compounds (5) to (7) and Nigersporium to obtain compounds (4) and (8), followed by extraction.
[0039] separate
[0040] a) Puccinia globosa
[0041] Endophytic fungi were isolated from fresh, healthy stems of Mint lipelum (Peppermint). The surface of the stem was sterilized with 70% ethanol for 1 min, followed by rinsing with sterile water to remove the ethanol. To distinguish endophytic fungi from any remaining epiphytic fungi, stem surface imprints were obtained on organic malt extract agar. A small sample of internal tissue is sterilely sectioned and pressed onto agar plates containing an antibiotic to inhibit bacterial growth. The composition of the isolation...
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Abstract
The invention relates to the use of the following anthracene derivatives as anti-infectives, preferably against multiply drug-resistant pathogens: (2R,3S,10R)-2,3,5,10-tetrahydroxy-6-methoxy-3-methyl-1,2,3,4,4a,9a-hexahydro-9H,10H-anthracen-9-one (tetrahydroaltersolanol B), (1R,2R,3R,4aS,9aR,10R)-1,2,3,5,10-pentahydroxy-7-methoxy-2-methyl-1,2,3,4,4a,9a-hexahydro-9H,10H-anthracen-9-one (altersolanol K), (2R,3R,4R,4aS,9aS,10R)-2,3,4,8,10-pentahydroxy-6-methoxy-3-methyl-1,2,3,4,4a,9a-hexahydro-9H,10H-anthracen-9-one (altersolanol L), 8-(1,7-dihydroxy-6-methyl-3-methoxy-9,10-dioxo-9H,10H-anthracen-2-yl)(1S,2S,3R,4S)-1,2,3,4,5-pentahydroxy-7-methoxy-2-methyl-1,2,3,4-tetrahydro-9H,10H-anthracene-9,10-dione (atropisomers alterporriol G and H); and (2R,3S,4aS,9aS,10R)-2,3,5,8,10-pentahydroxy-6-methoxy-3-methyl-1,2,3,4,4a,9a-hexahydro-9H,10H-anthracen-9-one (8-hydroxytetrahydroaltersolanol B).
Description
technical field [0001] The present invention relates to the use of anthracene derivatives as anti-infective drugs, especially anti-multi-drug resistant pathogen infection, and a preparation method thereof. Background technique [0002] In the late 1960s and early 1970s, due to the very successful use of antimicrobial drugs, it was assumed that infectious diseases would no longer pose any risk. However, this proved to be a misconception, and, four decades later, microbes are posing a greater threat than ever. For these reasons, new antimicrobial agents are urgently needed. Today, infectious diseases are the third most common cause of death in the United States and the second most common cause of death globally. Ineffective antimicrobial drugs are responsible for most of these conditions, and resistance of certain bacteria and fungi to these drugs is a serious problem facing our society. According to US statistics, most infections that occur in hospitals (so-called nosocomi...
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