Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!
Use of anthracene derivatives as anti-infectives
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A technology of anti-infective drugs and anthracene derivatives, applied in the field of anthracene derivatives as anti-infective drugs, can solve the problems of unknown effect and the like
Inactive Publication Date: 2012-05-30
SEALIFE PHARMA
View PDF1 Cites 5 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
Although a parallel, simultaneously filed Austrian patent application with application number A 842 / 09 provides two new compounds, an altersolanol and an alterporriol derivative, the present invention relates to the use of various compounds, the structures of which are known from the literature , but its effect is so far unknown
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
Embodiment Construction
[0037] Hereinafter, the present invention is described in further detail with reference to specific exemplary embodiments, however, this is not meant to limit the scope of the present invention in any way.
[0038] Compounds of chemical formulas (4) to (8) are obtained by culturing Puccinia glomerulus to obtain compounds (5) to (7) and Nigersporium to obtain compounds (4) and (8), followed by extraction.
[0039] separate
[0040] a) Puccinia globosa
[0041] Endophytic fungi were isolated from fresh, healthy stems of Mint lipelum (Peppermint). The surface of the stem was sterilized with 70% ethanol for 1 min, followed by rinsing with sterile water to remove the ethanol. To distinguish endophytic fungi from any remaining epiphytic fungi, stem surface imprints were obtained on organic malt extract agar. A small sample of internal tissue is sterilely sectioned and pressed onto agar plates containing an antibiotic to inhibit bacterial growth. The composition of the isolation...
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
PUM
Login to View More
Abstract
The invention relates to the use of the following anthracene derivatives as anti-infectives, preferably against multiply drug-resistant pathogens: (2R,3S,10R)-2,3,5,10-tetrahydroxy-6-methoxy-3-methyl-1,2,3,4,4a,9a-hexahydro-9H,10H-anthracen-9-one (tetrahydroaltersolanol B), (1R,2R,3R,4aS,9aR,10R)-1,2,3,5,10-pentahydroxy-7-methoxy-2-methyl-1,2,3,4,4a,9a-hexahydro-9H,10H-anthracen-9-one (altersolanol K), (2R,3R,4R,4aS,9aS,10R)-2,3,4,8,10-pentahydroxy-6-methoxy-3-methyl-1,2,3,4,4a,9a-hexahydro-9H,10H-anthracen-9-one (altersolanol L), 8-(1,7-dihydroxy-6-methyl-3-methoxy-9,10-dioxo-9H,10H-anthracen-2-yl)(1S,2S,3R,4S)-1,2,3,4,5-pentahydroxy-7-methoxy-2-methyl-1,2,3,4-tetrahydro-9H,10H-anthracene-9,10-dione (atropisomers alterporriol G and H); and (2R,3S,4aS,9aS,10R)-2,3,5,8,10-pentahydroxy-6-methoxy-3-methyl-1,2,3,4,4a,9a-hexahydro-9H,10H-anthracen-9-one (8-hydroxytetrahydroaltersolanol B).
Description
technical field [0001] The present invention relates to the use of anthracene derivatives as anti-infective drugs, especially anti-multi-drug resistant pathogen infection, and a preparation method thereof. Background technique [0002] In the late 1960s and early 1970s, due to the very successful use of antimicrobial drugs, it was assumed that infectious diseases would no longer pose any risk. However, this proved to be a misconception, and, four decades later, microbes are posing a greater threat than ever. For these reasons, new antimicrobial agents are urgently needed. Today, infectious diseases are the third most common cause of death in the United States and the second most common cause of death globally. Ineffective antimicrobial drugs are responsible for most of these conditions, and resistance of certain bacteria and fungi to these drugs is a serious problem facing our society. According to US statistics, most infections that occur in hospitals (so-called nosocomi...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.