Use of artemisinin derivatives for treatment of asthma and chronic obstructive pulmonary disease (copd)

A technology of artemisinin derivatives and derivatives, applied in drug combination, ICT adaptation, respiratory system diseases, etc., can solve problems that have not been clearly determined

Inactive Publication Date: 2012-05-30
NAT UNIV OF SINGAPORE
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Problems solved by technology

The exact molecular mechanism by which artesunate mediates these anti-inflammatory effects has not been clearly defined

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  • Use of artemisinin derivatives for treatment of asthma and chronic obstructive pulmonary disease (copd)
  • Use of artemisinin derivatives for treatment of asthma and chronic obstructive pulmonary disease (copd)
  • Use of artemisinin derivatives for treatment of asthma and chronic obstructive pulmonary disease (copd)

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Embodiment approach

[0107]Our findings reveal for the first time that artesunate significantly inhibits the phosphorylation of Akt(ser473) and inhibits its downstream kinases in vivo in OVA-stimulated lungs and in vitro in EGF-stimulated normal human bronchial epithelial cells . In summary, we demonstrate that the antimalarial drug artesunate, a semisynthetic derivative of artemisinin isolated from the herb Artemisia annua, can effectively suppress OVA-induced Th2-mediated Multiple aspects of allergic airway inflammation. Without being bound by any theory, we speculate that artemisinin derivatives such as artesunate may attenuate allergic asthma by inhibiting the P13KAkt signaling pathway. We demonstrate that artemisinin derivatives such as artesunate have therapeutic value in the treatment of asthma and COPD. We investigated the effects of artesunate on various aspects of ovalbumin (OVA)-induced Th2-mediated allergic airway inflammation in an in vivo mouse model of asthma, and investigated the...

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Abstract

Artesunate is a derivative of artemisinin isolated from a Chinese herb Artemisia annua L. It is used clinically for the treatment of malaria. We investigated potential anti-inflammatory actions of artemisinin derivatives. artemisinin derivatives significantly inhibited OVA-induced signs, symptoms and parameter of airway disorders Taken together, our results clearly demonstrate anti-inflammatory effects of artemisinin derivatives. Artemisinin derivatives can be used to complement or to replace oral steroids during asthma exacerbation treatment. Further artemisinin derivatives can be used as an anti-inflammatory agent for controlling airway disorders.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of and priority to US Provisional Patent Application No. 61 / 162,868, filed March 24, 2009, the contents of which are hereby incorporated by reference. technical field [0003] The present application relates to the use of artemisinin derivatives, such as artesunate compounds, for the treatment of asthma and chronic obstructive pulmonary disease. Background technique [0004] Currently, approximately 300,000,000 people in the world suffer from asthma. The incidence is expected to rise to 400,000,000 in 2025. Three anti-inflammatory agents are currently used to control asthma, including inhaled steroids, cysteinyl leukotriene receptor antagonists, and cromolyn. However, the therapeutic effect of cysteinyl leukotriene receptor antagonists and cromolyn sodium is highly variable and may be limited to certain subpopulations of patients. In addition, 5%-10% of asthmatics are not well con...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/357A61P11/06C07D493/18A61K31/56A61P11/08A61K31/352A61P11/00C07D493/00
CPCA61K31/357C07D493/18A61K31/366A61K31/573A61K31/58A61P11/00A61P11/06A61P11/08Y02A50/30Y02A90/10A61K2300/00
Inventor 黄玮韶
Owner NAT UNIV OF SINGAPORE
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