Method for detecting quality of traditional Chinese medicine capsules for regulating collateral channels and soothing liver

A technology of traditional Chinese medicine preparations and detection methods, which is applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve problems such as poor reproducibility, poor quality controllability, and poor operability, and achieve stable reproducibility, improve effective control, and improve Effects of Safety and Efficacy

Active Publication Date: 2013-12-25
乐泰药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention aims to solve the problems of poor quality controllability, poor reproducibility, and poor operability existing in the existing quality standards of Heluoshugan Capsules, and provides a quality detection method for traditional Chinese medicine preparations and Luoshugan Capsules

Method used

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  • Method for detecting quality of traditional Chinese medicine capsules for regulating collateral channels and soothing liver
  • Method for detecting quality of traditional Chinese medicine capsules for regulating collateral channels and soothing liver
  • Method for detecting quality of traditional Chinese medicine capsules for regulating collateral channels and soothing liver

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specific Embodiment approach 1

[0012] Specific embodiment one: the quality detection method of Chinese medicine preparation and Luoshugan capsule of the present embodiment, carry out according to the following steps: One, take α-cyperone as reference substance, adopt thin-layer chromatography to identify and Luoshugan capsule prescription Whether it contains Cyperus cyperi; 2. Taking Curcuma as the reference medicinal material, using TLC to identify whether the prescription of Heluoshugan Capsules contains Curcuma components; Whether there is Bupleurum in the prescription of Gan Capsules; 4. Taking paeoniflorin as the reference substance, use thin-layer chromatography to identify whether the prescription of Luoshugan Capsules contains Radix Paeoniae Alba; method to identify whether the prescription of Heluoshugan Capsules contains Atractylodes Rhizoma Atractylodes Rhizome; 6. Taking Angelica as the reference medicinal material, use TLC to identify whether the prescription of Heluoshugan Capsules contains Ang...

specific Embodiment approach 2

[0013] Specific embodiment 2: The difference between this embodiment and specific embodiment 1 is that in step 1, α-cyperone is used as a reference substance, and the method of using thin layer chromatography to identify and whether the prescription of Luoshugan Capsules contains Cyperus components For: 1.1, the preparation of test solution: take 5g and Luoshugan capsule content, add 20mL ethanol, ultrasonic treatment 15min, filter, filtrate evaporates to dryness, residue adds 10mL ethyl acetate, ultrasonic treatment 10min, filter, Concentrate the filtrate to 0.5mL as the test solution; 1.2, take α-cyperone as the reference substance, add ethyl acetate to make a 1mg / mL solution, and use it as the reference substance solution; 1.3, press Heluoshugan Capsules Proportioning of the prescription Weigh other medicinal materials except Cyperus cyperi, prepare according to the original standard of the second volume of traditional Chinese medicine preparations in the "Drug Standards of ...

specific Embodiment approach 3

[0015] Specific embodiment three: the difference between this embodiment and specific embodiment one is that in step 2, using curcuma as a reference medicinal material, the method of using TLC to identify whether the prescription of Luoshugan capsules contains curcuma is as follows: 2.1. Preparation of the test solution: take 5g of the content of Luoshugan Capsules, add 15mL of n-hexane, sonicate for 5min, filter, take the subsequent filtrate as the test solution; Alkanes, sonicated for 5min, filtered, and the filtrate was taken as the reference solution; 2.3, according to the ratio of Luoshugan Capsules prescription, weigh other medicinal materials except curcuma, according to the "Ministry of Health Drug Standards" traditional Chinese medicine formula The preparation method on the original standard of the second volume of the preparation, take 5g of the prepared granules, prepare according to the preparation method of the test solution described in step 2.1, and use it as the...

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Abstract

The invention discloses a method for detecting quality of Chinese medicinal capsules for regulating collateral channels and soothing liver, and aims to solve the problems of low quality controllability, repeatability, and operability of the current quality standard of the capsules for regulating collateral channels and soothing liver. The method comprises the following steps of: identifying whether the capsules for regulating collateral channels and soothing liver contain the component of cyperus rotundus by a thin layer chromatography; identifying whether the capsules for regulating collateral channels and soothing liver contain the component of zedoary by the thin layer chromatography; identifying whether the capsules for regulating collateral channels and soothing liver contain the component of bupleurum by the thin layer chromatography; identifying whether the capsules for regulating collateral channels and soothing liver contain the component of white paeony root by the thin layer chromatography; identifying whether the capsules for regulating collateral channels and soothing liver contain the component of white atractylodes rhizome by the thin layer chromatography; identifying whether the capsules for regulating collateral channels and soothing liver contain the component of Chinese angelica by the thin layer chromatography; and identifying the component of the white paeony root in the capsules for regulating collateral channels and soothing liver by a high performance liquid chromatography. The method is stable in repeatability, high in operability and high in quality controllability.

Description

technical field [0001] The invention relates to a quality detection method of traditional Chinese medicine preparations and Luoshugan capsules. Background technique [0002] Heluo Shugan Capsules are composed of white peony root, rhizoma cyperi, curcuma, fried Atractylodes macrocephala, Sanleng, angelica, papaya, rhubarb, safflower, roasted turtle shell, peach kernel, turmeric, capillary, seaweed, kelp, scrophulariaceae, rehmannia glutinosa , Rehmannia glutinosa, Polygonum cuspidatum, Wood beetle, Bupleurum, Polygonum multiflorum, Ling Xiaohua, Dung beetle, Wulingzhi, black beans, Lobelia 27 traditional Chinese medicines. Its function is to soothe the liver and regulate qi, clear away dampness and heat, promote blood circulation and remove blood stasis, and nourish the liver and kidney. It is often used to treat mild, moderate and early cirrhosis of chronic hepatitis. It is a traditional Chinese medicine preparation for the treatment of liver diseases. [0003] The quality ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/90G01N30/02
Inventor 郎伟君
Owner 乐泰药业有限公司
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