Fexofenadine hydrochloride oral disintegrating drug composition
A fexofenadine, orally disintegrating technology, applied in the field of fexofenadine hydrochloride orally disintegrating pharmaceutical composition and its preparation, can solve the problem of high friability and fexofenadine hydrochloride Moisture sensitivity, easy oxidation, low hardness and low strength, etc., achieve high bioavailability, reduce market risk, and simple and easy method
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[0087] The orally disintegrating pharmaceutical composition of fexofenadine hydrochloride described in every 1000, its formula consists of:
[0088] Fexofenadine hydrochloride as fexofenadine 300g
[0089] Povidone 60g
[0090] Purified water 600g
[0091] Spray Dried Mannitol Spherical Granules 1500g
[0092] Talc powder 80g
[0093] Hypromellose E5LV 300g
[0094] Purified water 2000g
[0095] Croscarmellose Sodium 300g
[0096] Aspartame 50g
[0097] Silica 10g
[0098] Fexofenadine hydrochloride orally disintegrating pharmaceutical composition of the present invention is prepared by the following method:
[0099] 1) Fexofenadine hydrochloride coating preparation:
[0100] Fexofenadine hydrochloride as fexofenadine 300g
[0101] Povidone 60g
[0102] Purified water 600g
[0103] 2) Preparation of Fexofenadine Hydrochloride Granules: Put 1.5kg of spray-dried mannitol spherical particles with an average particle size of 100um into a fluidized bed coating agent, an...
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