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Micro-mixing device based on three-dimensional hydraulic focusing

A micro-mixing and three-dimensional technology, which is applied in the preparation and dissolution of mixers, samples for testing, etc., can solve the problems of cumbersome experimental operation process, complex structure, and difficult processing, and achieves wide application prospects, simple device structure, and high processing efficiency. simple effect

Active Publication Date: 2012-06-27
HUAZHONG UNIV OF SCI & TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The purpose of the present invention is to overcome the shortcomings of the existing three-dimensional hydraulic focusing micro-device with complex structure, difficult processing and complicated experimental operation process, and provide a micro-mixing device with simple structure, easy processing and good three-dimensional focusing effect

Method used

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  • Micro-mixing device based on three-dimensional hydraulic focusing
  • Micro-mixing device based on three-dimensional hydraulic focusing
  • Micro-mixing device based on three-dimensional hydraulic focusing

Examples

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Embodiment Construction

[0020] The present invention will be described in further detail below in conjunction with accompanying drawing and example.

[0021] A three-dimensional focusing micro-mixing device includes a bonded substrate and a cover sheet, and the inner surfaces of the substrate and the cover sheet are processed with the same microchannel structure. Such as image 3 As shown, the microchannel structure includes four connected channels, wherein the first and third channels 1 and 3 are used as side inlet channels, the second channel 2 is used as the middle inlet channel, the fourth channel 4 is used as the outlet channel, and the middle inlet The passage and the exit passage are on the same straight line, the entrance passages on both sides are symmetrical about the middle entrance passage, and the height of the middle entrance passage is lower than the other three passages.

[0022] The included angle between the middle entrance passage and the side entrance passage is less than 90 degr...

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Abstract

The invention discloses a micro-mixing device based on three-dimensional hydraulic focusing, which comprises a base sheet and a cover sheet that are bonded into a whole, wherein same micro-channel structures are processed on the inner surfaces on the base sheet and the cover sheet and comprise four communicated channels, the first and the third channels are used as sideway inlet channels, the second channel is used as an intermediate inlet channel, the fourth channel is used as an outlet channel, the intermediate inlet channel and the outlet channel are in the same straight line, the two sideway inlet channels are symmetrical with respect to the intermediate inlet channel, and the intermediate inlet channel is lower than the other three channels. The invention also provides a processing method of the micro-mixing device. The micro-mixing device realizes that a sample belt is focused into a submicron level in an XY direction and focused into a micron level in a YZ direction, and has the advantages of simple structure, easiness in processing and good three-dimensional focusing effect.

Description

technical field [0001] The invention relates to a micro-mixing device based on three-dimensional hydraulic focusing, which can focus a sample solution into a micron beam at a three-dimensional angle, realize rapid mixing of the solution, and is widely used in the field of kinetic research of biomacromolecules. Background technique [0002] Microfluidic lab-on-a-chip, also known as microfluidics or lab-on-a-chip, refers to a chemical or biological laboratory built on a chip of a few square centimeters. This kind of analysis system is small in size and can integrate operation units such as sample injection, pretreatment, mixing, reaction, and detection, so that the analysis time is greatly shortened, the detection resolution / sensitivity is significantly improved, and the consumption and cost are also greatly reduced. At this stage, microfluidic chips have been involved in fields including disease diagnosis, drug screening, environmental testing, food safety, judicial identific...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01F13/00G01N1/38
Inventor 刘笔锋徐友志李颖刘超刘欣
Owner HUAZHONG UNIV OF SCI & TECH
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