Soft capsule for improving cranial nerve function and preparation method thereof

A technology of soft capsules and cranial nerves, which is applied in the fields of capsule delivery, nervous system diseases, drug combinations, etc., can solve the problems of slow onset and decline of glycerol phosphorylcholine, and achieve stable quality, easy to take, and simple preparation steps Effect

Inactive Publication Date: 2012-07-11
JINAN KANGHE MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In a 12-week randomized study comparing the efficacy of the same dose of glycerophosphorylcholine and oxiracetam in 55-65 year old male patients with geriatric organic brain syndrome, it was shown that both had good effects. Tolerance, no patient stopped treatment due to adverse reactions; Oxiracetam has a rapid onset of curative effect in maintenance therapy, but rapidly declines with the cessation of treatment; glycerophosphorylcholine has a slower onset effect than Slower, but more durable effects, 8 weeks after discontinuation of treatment consistent with clinical effects during 8 weeks of treatment

Method used

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  • Soft capsule for improving cranial nerve function and preparation method thereof
  • Soft capsule for improving cranial nerve function and preparation method thereof
  • Soft capsule for improving cranial nerve function and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017]

[0018] Preparation steps:

[0019] (1) Preparation of solution A: After adding glycerol phosphorylcholine to the solvent, heat it to 37°C in a liquid mixing tank and stir until it is evenly mixed, then transfer to a colloid mill and grind until it is completely dissolved and becomes clear and transparent. Turn on the vacuum pump, move it to the hopper of the soft capsule machine for standby after defoaming, and set the temperature of the hopper to 37°C;

[0020] (2) Preparation of solution B: After mixing the capsule shell materials, heat to 37°C in a liquid mixing tank and stir until evenly mixed, then transfer to a colloid mill and grind until completely dissolved until clear and transparent. Turn on the vacuum pump, move it to the hopper of the soft capsule machine for standby after defoaming, and set the temperature of the hopper to 37°C;

[0021] (3) A and B are pressed into soft capsules by a soft capsule machine;

[0022] (4) The soft capsules were placed ...

Embodiment 2

[0024]

[0025] Preparation steps:

[0026] (1) Preparation of solution A: After adding glycerol phosphorylcholine to the solvent, heat it to 40°C in a liquid mixing tank and stir until it is evenly mixed, then transfer it to a colloid mill and grind until it is completely dissolved and becomes clear and transparent. Turn on the vacuum pump, move it to the hopper of the soft capsule machine for standby after degassing, and set the temperature of the hopper to 50°C;

[0027] (2) Preparation of solution B: After mixing the capsule shell materials, heat to 80°C in a liquid mixing tank and stir until evenly mixed, then transfer to a colloid mill and grind until completely dissolved until clear and transparent. Turn on the vacuum pump, move it to the hopper of the soft capsule machine for standby after defoaming, and set the temperature of the hopper to 80°C;

[0028] (3) A and B are pressed into soft capsules by a soft capsule machine;

[0029] (4) The soft capsules were plac...

Embodiment 3

[0031]

[0032] Preparation steps:

[0033] (1) Preparation of solution A: After adding glycerol phosphorylcholine to the solvent, heat it to 80°C in a liquid mixing tank and stir until it is evenly mixed, then transfer it to a colloid mill and grind until it is completely dissolved and becomes clear and transparent. Turn on the vacuum pump, move it to the hopper of the soft capsule machine for standby after defoaming, and set the temperature of the hopper to 80°C;

[0034] (2) Preparation of solution B: After mixing the capsule shell materials, heat them to 50°C in a liquid mixing tank and stir until they are evenly mixed, then transfer them to a colloid mill and grind until they are completely dissolved and become clear and transparent. Turn on the vacuum pump, move it to the hopper of the soft capsule machine for standby after degassing, and set the temperature of the hopper to 55°C;

[0035] (3) A and B are pressed into soft capsules by a soft capsule machine;

[0036...

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Abstract

The invention relates to a soft capsule for improving the cranial nerve function and a preparation method thereof. The soft capsule comprises content and a capsule shell material; the content comprises glyceryl phosphoryl choline and a solvent, wherein the glyceryl phosphoryl choline accounts for 60-95% of the total weight of the content; the solvent accounts for 5-40% of the total weight of the content; the solvent comprises one or several of water, glycerol, sorbitol, sorbitan, glycerol triacetate, polyethylene glycol 200, polyethylene glycol 400 and propylene glycol; and the capsule shell material comprises one or several of gelatin, water, glycerol, sorbitol, sorbitan, methylparaben, ethylparaben, propylparaben, titanium dioxide and iron oxide yellow. The preparation method comprises the following steps of: pressing a solution A prepared by the glyceryl phosphoryl choline and the solvent and a solution B prepared by the capsule shell material into soft capsules by a soft capsule machine; and drying to obtain the soft capsule for improving the cranial nerve function.

Description

technical field [0001] The design of the invention belongs to the technical field of medicine, and in particular relates to a soft capsule for improving brain nerve function and a preparation method thereof. Background technique [0002] Glycerophosphoryl Choline has the potential to prevent and treat various biochemical lesions. Clinical studies have shown that it is beneficial to the cognitive and memory functions of the brain. It is an important neurotransmitter and phospholipid precursor, which can improve the cognitive ability and memory of the elderly and protect blood vessels. [0003] Its chemical structural formula is as follows: [0004] [0005] Glycerophosphorylcholine has a good curative effect on memory impairment in the elderly. This drug is a pioneer of acetylcholine cranial nerve drugs and phospholipid nerve membrane drugs. In a 12-week randomized study comparing the efficacy of the same dose of glycerophosphorylcholine and oxiracetam in 55-65 year old ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K31/6615A61P25/28
Inventor 张颖李刚张作平
Owner JINAN KANGHE MEDICAL TECH
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