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Sinomenine vesicle and its preparation and preparation method

A technology for sinomenine and vesicles, which is applied in the field of sinomenine vesicles and their preparation, can solve problems such as limited application, and achieve the effects of reducing toxic and side effects, increasing drug efficacy and improving safety.

Active Publication Date: 2016-03-02
BEIJING INCREASEPHARM CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As the active ingredient of the traditional Chinese medicine Qingfengteng, sinomenine has remarkable clinical curative effect, but there are the above-mentioned shortcomings, which greatly limit its clinical application

Method used

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  • Sinomenine vesicle and its preparation and preparation method
  • Sinomenine vesicle and its preparation and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0085] Take 3g of sinomenine, 4028g of Tween, and 30g of cholesterol, dissolve them in absolute ethanol, remove the solvent by rotary evaporation (60°C), add it into the ammonium sulfate buffer solution with a pH of 6.8, stir at 20°C until the ethanol is completely evaporated, and ultrasonicate for 30min , standing at room temperature for cooling, and the vesicle suspension of sinomenine is obtained.

[0086] Take 94150g of carbomer, 15g of glycerin, 6g of potassium sorbate, add 100ml of purified water to prepare a blank gel matrix, and mix the vesicle suspension and the blank gel matrix to obtain the vesicle gel.

Embodiment 2

[0088] Take 5g of sinomenine, 8050g of Span, and 45g of stearamide, dissolve in ether, remove the solvent by rotary evaporation (60°C), dry in vacuum overnight, add to ammonium sulfate buffer solution with a pH of 6.5, and hydrate at a temperature of 60°C. The time is 30 minutes, and the vesicle suspension of sinomenine is obtained by processing with a high-pressure homogenizer.

[0089] Take 98015g of carbomer, 120g of propylene glycol, 5g of azone, 7g of triethylamine, 10g of sorbic acid, add 3000ml of purified water to prepare a blank gel matrix, and mix the blank gel matrix with the vesicle suspension to obtain Vesicle gel.

Embodiment 3

[0091] Take 10g of sinomenine, 20-250g of Span, and 45g of stearamide, dissolve them in methanol, remove the solvent by rotary evaporation (55°C), add purified water for hydration, the hydration temperature is 65°C, the hydration time is 45min, and ultrasonic treatment is 30 minutes to obtain the green Vesicle suspension of Phytine.

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Abstract

The invention discloses a sinomenine vesicle and a preparation method thereof, a preparation containing the sinomenine vesicle and a preparation method of the preparation, which belong to the field of medicament preparations. The sinomenine vesicle is prepared from sinomenine, a nonionic surfactant and an additive. The sinomenine vesicle is preferably prepared into external gel. A sinomenine transdermal administration external preparation has a unique advantage to the medicament. Due to the application of a novel vesicle administration system, transdermal absorption of the medicament is improved, and a clinical curative effect is enhanced. The sinomenine vesicle can be used for treating rheumatism, rheumatoid arthritis, a glomerular disease, hyperosteogeny, spondylitis, arrhythmia, systemic lupus erythematosus, a heroin addict withdrawal symptom and the like.

Description

technical field [0001] The invention relates to sinomenine vesicles and a preparation method thereof, a preparation containing sinomenine vesicles and a preparation method thereof, and belongs to the field of pharmaceutical preparations. Background technique [0002] The traditional Chinese medicine Qingfengteng is also known as Qingfengteng, Qingteng, and Xunfengteng. The sources of medicinal materials are inconsistent all over the country, and they are the canes of the Fangjiaceae plant Qingteng, Huafangji or Qingfengvineae plant Qingteng. According to the current medicinal situation, it is mainly Sinomenium acutum [Thunb.] Rehd.etWils., which is a plant of Fanghei family. Sinomenium acutum is bitter and flat, and it returns to the liver and spleen meridian, which can dispel rheumatism, dredge meridians, and relieve pain. , the effect of diuresis, can be used for rheumatoid arthritis, joint swelling, limb pain and numbness. Over the years, many scholars have reported tha...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/127A61K9/00A61K31/473A61K31/485A61P9/06A61P9/12A61P13/12A61P19/02A61P19/04A61P19/08A61P25/20
Inventor 胡杰张永丽
Owner BEIJING INCREASEPHARM CORP LTD
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