30 results about "Spondylarthritis" patented technology

A preparation method of volcanic mud black ointment, which is composed of 20-30% of medicinal pills prepared from Chinese herbal medicines, 10-20% of medicinal vaseline, 50-60% of volcanic mud and 10-20% of vegetable oil. Hot compress of mud black ointment on the lesions of the body can quickly open up the meridians of the whole body, promote blood circulation in the body, and treat waist and leg pain, hip joint disease, internal rheumatoid arthritis, ankylosing spondylitis, osteoporosis, lumbar disc herniation, cervical spondylosis and bone hyperplasia.

The problem of the present invention is to provide a compound having a superior RORγt inhibitory action, and useful as a prophylactic or therapeutic agent for psoriasis, inflammatory bowel disease, ulcerative colitis, Crohn's disease, rheumatoid arthritis, multiple sclerosis, uveitis, asthma, ankylopoietic spondylarthritis, systemic lupus erythematosus, chronic obstructive pulmonary disease or the like. The present invention relates to a compound represented by the formula (I):[wherein each symbol is as described in the DESCRIPTION] or a salt thereof, which has an RORγt inhibitory action, and useful as a prophylactic or therapeutic agent for psoriasis, inflammatory bowel disease, ulcerative colitis, Crohn's disease, rheumatoid arthritis, multiple sclerosis, uveitis, asthma, ankylopoietic spondylarthritis, systemic lupus erythematosus, chronic obstructive pulmonary disease or the like.

The invention discloses powder for treating cervical spondylosis, intervertebral disc herniation, ankylosing spondylitis and hyperosteogeny, and belongs to the field of Chinese medicines. The powder consists of the following components: common monkshood mother root, kusnezoff monkshood root, frankincense, myrrh, aconitum pendulum busch, divaricate saposhnikovia root, yellowmouth dutchmanspipe root, spreading hedyotis herb, long-noded pit viper, pangolin scales, centipede, astragalus, wooly datchmanspipe herb, mulberry twig, white mulberry root-bark, east Asian tree fern rhizome, dragon's blood, pyrite, clematis root and liquoric root. A preparation method for the powder comprises the following steps of: crushing the medicaments into superfine powder, bagging, and soaking in distilled spirit. When the powder is used, a Chinese medicinal bag is applied to wounds and is covered by a plastic film to be sealed and fixed, and is replaced after 24 hours. The powder has the effects of softening hardness to dissipate stagnation, promoting blood circulation and removing blood stasis, dispelling wind and eliminating cold, relieving swelling and pain, drawing out pus and promoting tissue regeneration and removing obstruction in channels to relieve pain, the effective rate is 95 percent, and the cure rate is 90 percent.

The invention relates to application of ozonized oil in small surgical incisions or other wound such as mucosal ulcer, diabetic feet, cervical erosion, anal fissure, anus fistula, soft tissue injury,fall damage wound surface, recurrent wound, abscess, acne, arthritis, joint degeneration, cystitis, furunculosis, neurological disorder osteomyelitis, gangrene, ulcus cruris, synovitis, gout, sinusitis, spondylitis, scapulohumeral periarthritis, lumbocrural pain, periostitis and stomatitis. Through the modes of oral administration, intraperitoneal injection, clyster, gavage, intravenous injection,subcutaneous injection, intramuscular injection, external application, drop and suppository, the diseases can be effectively prevented and treated.

The invention discloses a preparation method of traditional Chinese medicine for treating hypertrophic spondylitis, cervical spondylosis, heel spurs, proliferative arthritis and Kashin-Beck disease. The frankincense, myrrh, Corydalis Corydalis, Nuxystigma chinensis, notoginseng and dried blood are crushed by airflow The machine crushes the extract into superfine powder a, and mixes it evenly; the turmeric, woody, solitary, and cassia twigs are enzymatically hydrolyzed to obtain a clear paste b, and the dregs are added to the four flavors of white peony root, safflower, achyranthes bidentata, and Gentiana chinensis. The supernatant c obtained by carbon dioxide supercritical extraction method, b and c are combined, concentrated to a thick paste and dried, and the extract is crushed into ultrafine powder d with a jet mill, and a and d are mixed evenly, and added to a pharmaceutically acceptable The accepted excipients are mixed and encapsulated, and the invention has the advantages of complete extraction of active ingredients, high bioavailability, good absorption, stable quality, good reproducibility and the like.

The invention discloses special paste for relieving and promoting rehabilitation of bone diseases. The paste comprises, by mass, 5.6-7.8 parts of castor beans, 9.8-11.2 parts of radix angelicae, 6.7-8.9 parts of red peony root, 4.5-7.2 parts of rheum officinale, 2.3-4.5 parts of musk, 4.5-6.7 parts of momordica cochinchinensis, 7.2-9.8 parts of radix scutellariae, coptidis rhizome and cortex phellodendri, 3.1-5.2 parts of drynaria total flavonoids, 5.6-8.2 parts of earthworms, 7.5-9.4 parts of cortex cinnamomi, 5.2-8.6 parts of clove, 8.8-12.5 parts of pericarpium zanthoxyli, 2.4-7.8 parts ofcamphor, 10-16 parts of borneol and 120-150 parts of Vaseline. The paste can relieve femoral head necrosis, hyperosteogeny, cervical spondylosis, lumbar spondylosis, intervertebral disc herniation, rheumatic arthritis, ankylosing spondylitis, scapulohumeral periarthritis, traumatic injury and senile osteoarthritis, relax tendons and activating collaterals, relieve pain caused by gout, promote rehabilitation and the like.

The invention discloses an iliacus muscle oral liquid and a preparation method thereof. The iliacus muscle oral liquid comprises the components of, by weight, 27 parts of frankincense, 46 parts of myrrh, 91 parts of white peony root, 27 parts of rhizoma corydalis (processed with vinegar), 46 parts of pseudo-ginseng, 27 parts of radix aucklandiae, 46 parts of safflower carthamus, 91 parts of radix curcumae, 183 parts of radix angelicae pubescentis, 46 parts of radix achyranthis bidentatae, 183 parts of large-leaved gentian, 46 parts of cassia twig, 27 parts of resina draconis and 27 parts of semen strychni (fried). The iliacus muscle oral liquid is a pure traditional Chinese medicine composition oral liquid preparation and has the functions for hypertrophic myelitis, cervical spondylosis, heel spurs, hypertrophic arthritis, kashin-beck diseases, etc. Compared with iliacus muscle pills, iliacus muscle tablets, iliacus muscle capsules which are described in Chinese medicine ministerial standards, the iliacus muscle oral liquid has the advantages of small dosage, good taste, convenience for taking, relatively fast absorption, high bioavailability, stable quality, simple production process, etc.

The invention provides the use of a calcitonin in the preparation of a medicament for the treatment of an inflammatory disease or condition. The calcitonin may be selected from the group consisting of human, salmon, eel, porcine, bovine, or chicken calcitonin or a derivative, a fragment or a variant thereof. The inflammatory disease or condition may be rheumatoid arthritis (RA), juvenile rheumatoid arthritis (JRA), osteoarthritis, psoriasis, psoriatic arthritis, ankylosing spondylitis (AS), lupus erythamatosis, multiple sclerosis (MS), asthma, or immuno-suppressive therapy (e.g. post transplantation surgery). The treatment may also comprise administration of a glucocorticoid, an anti-rheumatic drug or an antibody.

The present invention relates generally to methods for diagnosing the presence or the risk of development or the therapy control of spondyloarthritis (Spa), in particular, of ankylosing spondylitis (AS) and undifferentiated spondyloarthritis in a subject, in particular in mammals. In addition, the present invention relates to test kits for use in the diagnosis of the presence or the risk of development, or for the therapy control of Spa, like AS and undifferentiated spondyloarthritis, in a subject. In particular, the present invention relates to a method for diagnosing the presence or the risk of development, or for the therapy control of Spa, like AS and undifferentiated spondyloarthritis, in a subject analysing for the presence of autoantibodies against CD74 and / or IKBKB in a subject. The presence of autoantibodies against CD74 and / or IKBKB is indicative for the presence or the risk of development, or for the therapy control of Spa, like AS and undifferentiated spondyloarthritis. In particular, detection of the presence of autoantibodies against CD74 and / or IKBKB allows early diagnosis of Spa, in particular, AS and undifferentiated spondyloarthritis.

The invention discloses an anti-osteoproliferation preparation for treating orthopedic diseases, a preparation method and a quality control method thereof, and belongs to the technical field of traditional Chinese medicines. It is mainly composed of Rehmannia glutinosa, steamed cistanche, salted dog ridge, salted Ligustrum lucidum, epimedium, chicken blood vine, fried radish seeds, drynaria, and achyranthes plus appropriate amount of accessories, respectively made into injection preparations and Various oral preparations such as dripping pills, micro-pills, dispersible tablets, etc., also provide the content determination and identification methods of this preparation; it is mainly used for the treatment of proliferative spondylitis, including hypertrophic thoracic spondylitis, hypertrophic lumbar spondylitis, cervical syndrome, Bone spurs and other diseases, the technology is reasonable, the quality is controllable, it is convenient to take, and the appearance is beautiful and clean.

The invention discloses a sinomenine vesicle and a preparation method thereof, a preparation containing the sinomenine vesicle and a preparation method of the preparation, which belong to the field of medicament preparations. The sinomenine vesicle is prepared from sinomenine, a nonionic surfactant and an additive. The sinomenine vesicle is preferably prepared into external gel. A sinomenine transdermal administration external preparation has a unique advantage to the medicament. Due to the application of a novel vesicle administration system, transdermal absorption of the medicament is improved, and a clinical curative effect is enhanced. The sinomenine vesicle can be used for treating rheumatism, rheumatoid arthritis, a glomerular disease, hyperosteogeny, spondylitis, arrhythmia, systemic lupus erythematosus, a heroin addict withdrawal symptom and the like.

The invention provides antibodies or binding fragments thereof directed against citrulline-containing epitopes. The antibodies or binding fragments thereof of the invention can be used in therapy, for example in the treatment or prevention of Neutrophil Extracellular Trap (NET)-associated pathologies. The antibodies or binding fragments thereof of the invention can be used in the treatment or prevention of NET-associated pathologies such as systemic lupus erythematosus (SLE), lupus, sepsis, vasculitis, inflammatory arthritis, rheumatoid arthritis and osteoarthritis, psoriasis, Alzheimer's disease, autoimmune hepatitis, juvenile idiopathic arthritis, Sjögren's disease, Anti-phospholipid Syndrome, Bechet's disease, spondylitis, spondyloarthropathy, multiple system atrophy, Parkinson's disease, Lewy body dementia asthma, allergic rhinovirus exacerbated asthma, allergic asthma, cystic fibrosis, fibrosis and idiopathic pulmonary fibrosis, dry eye disease, uveitis, nongranulomatous uveitis, granulomatous uveitis, dermatitis, atopic dermatitis, COPD, bronchitis, or other NET-associated pathologies such as wound healing in diabetes, cancer, cancer metastasis, and transplant organ health in vivo or ex vivo. The invention also provides pharmaceutical compositions and methods for treating or preventing NET-associated pathologies such as SLE, lupus, sepsis, vasculitis, inflammatory arthritis, rheumatoid arthritis and osteoarthritis, psoriasis, Alzheimer's disease, autoimmune hepatitis, juvenile idiopathic arthritis, Sjögren's disease, Anti-phospholipid Syndrome, Bechet's disease, spondylitis, spondyloarthropathy, multiple system atrophy, Parkinson's disease, Lewy body dementia asthma, allergic rhinovirus exacerbated asthma, allergic asthma, cystic fibrosis, fibrosis and idiopathic pulmonary fibrosis, dry eye disease, uveitis, nongranulomatous uveitis, granulomatous uveitis, dermatitis, atopic dermatitis, COPD, bronchitis, or other NET-associated pathologies such as wound healing in diabetes, cancer, cancer metastasis, and transplant organ health in vivo or ex vivo.

The invention discloses medicinal composition for remedying fracture, luxation and soft tissue injury and a preparation method thereof. The composition comprises 46 components of raw medicines such asangelica, safflower, Chinese flowering quince, achyranthes root, dahurian angelica root, eucommia ulmoies, herba schizonepetae, ledebouriella root and atractylodes rhizome, etc. The medicinal composition of the invention has the advantages of blood circulation promotion by removing blood stasis, reunion of the bone, expelling wind and removing damness, dispersing cold and relieving pain, and hasobvious effect to fracture remedy and soft tissue injury, simultaneously, the invention has good curative effect to the remedy of various paralysis arthralgia such as muscular rheumatism, rheumatoid disease, spondylitis spondylitis, senile arthritis, and neck, shoulder and arm pain and lumbago and scelalgia.

The invention discloses a bone moxibustion herbal formula which comprises the following components in parts by weight: 6-8 parts of ilex ficoidea, 1-2 parts of aechynanathus austroyunna-nensis, 1-1.5 parts of boston ivy, 1-2 parts of treebine stem, 1-2.5 parts of stem of climbing etada, 1-2.5 parts of Codariocalyx motorius, 1-1.5 parts of Dayaoye, 1-2 parts of radix zanthoxyli, 1-2.5 parts of codonopsis pilosula and cortex phellodendri, 1-3 parts of fructus rosae laevigatae, 6-7 parts of Ziqiangye and 0.7-1.5 parts of other traumatic injury medicines. Leaves of ilex ficoidea, leaves of aechynanathus austroyunna-nensisand stems and leaves of boston ivyare taken as the components. The preparation process is simple, the preparation process is environment-friendly and pollution-free, the herbal formula has good functions of diminishing inflammation and swelling, relieving pain and dissipating blood stasis, liquor is used for blending, time and labor are saved, materials are cheap, the medicine can better enter the body of a patient under the volatilization of alcohol, the treatment effect is better guaranteed, and great convenience is brought for the treatment work. Longan leaves are added, so that the herbal formula has a remarkable treatment effect on diseases such as cervical vertebra hyperosteogeny, lumbar vertebra hyperosteogeny, lumbar disc herniation, ankylosing spondylitis, rheumatoid arthritis, sciatic nerve injury, traumatic injury and the like.