30 results about "Spondylarthritis" patented technology

The invention discloses an externally applied plaster for stopping muscles and bones pain, which can be used for treating diseases including rheumatism, rheumatoid disease, hypertrophy spondylitis, periarthritis humeroscapularis, hyperosteogeny and waist disc herniation. The medicament is mainly prepared from quasi black multiple lunge ant as the main ingredient, as well as other 71 kinds of Chinese medicinal herbs.

The invention discloses medicinal composition for remedying fracture, luxation and soft tissue injury and a preparation method thereof. The composition comprises 46 components of raw medicines such asangelica, safflower, Chinese flowering quince, achyranthes root, dahurian angelica root, eucommia ulmoies, herba schizonepetae, ledebouriella root and atractylodes rhizome, etc. The medicinal composition of the invention has the advantages of blood circulation promotion by removing blood stasis, reunion of the bone, expelling wind and removing damness, dispersing cold and relieving pain, and hasobvious effect to fracture remedy and soft tissue injury, simultaneously, the invention has good curative effect to the remedy of various paralysis arthralgia such as muscular rheumatism, rheumatoid disease, spondylitis spondylitis, senile arthritis, and neck, shoulder and arm pain and lumbago and scelalgia.

Novel and highly stable injectable pharmaceutical compositions comprising at least one cyclooxygenase-II enzyme (COX-II) inhibitor or non-steroidal anti-inflammatory drug (NSAID) or COX / LOX inhibitor, or its tautomeric forms, analogues, isomers, polymorphs, solvates, prodrugs or salts thereof as active ingredient suitable for parenteral administration preferably by intramuscular (IM) or intravenous (IV) route; process of preparing such compositions and therapeutic methods of using such compositions are provided. The analgesic and anti-inflammatory injectable compositions of the present invention are very useful in mammals particularly in humans for the treatment of acute painful conditions like one or more of post-operative trauma, pain associated with cancer, sports injuries, migraine headache, neurological pain and pain associated with sciatica and spondylitis, and the like, and / or chronic painful conditions, and / or a variety of painful and inflammatory conditions like postoperative pain, primary dysmenorrhea and painful osteoarthritis, and / or other associated disorders such as inflammation, fever, allergy, or the like.

A preparation method of volcanic mud black ointment, which is composed of 20-30% of medicinal pills prepared from Chinese herbal medicines, 10-20% of medicinal vaseline, 50-60% of volcanic mud and 10-20% of vegetable oil. Hot compress of mud black ointment on the lesions of the body can quickly open up the meridians of the whole body, promote blood circulation in the body, and treat waist and leg pain, hip joint disease, internal rheumatoid arthritis, ankylosing spondylitis, osteoporosis, lumbar disc herniation, cervical spondylosis and bone hyperplasia.

A medicine for expelling pathogenic wind, relieving pain and resisting hyperosteogeny is prepared from 29 Chinese medicinal herbs such as Aconitum carmichaeli, Aconitum kusnezoffii, Rhizoma Arisaematis, Rhizoma Dioscoreae Septemlobae, Dioscorea nipponica, Lycopodium japonicum, Prunus mume, Gastrodia elata, Ligusticum chuanxiong, Cynanchum paniculatum, Chaenomeles speciosa fruit, Radix Clematidis, Achyranthes bidentata, Ramulus Cinnamomi, processed Rehmannia glutinosa, Angelica pubescens, Carthamus tinctorius flower, Saposhnikovia divaricata, and Eupolyphaga Seu Steleophaga. The medicine can be used for primary treatment of hyperosteogeny, rheumatic arthritis, rheumatalgia calcaneal spur, proliferative arthritis, cervical spondylosis, proliferative arthritis, Kaschin-Beck disease, numbness and pain in arm, gait difficulty, cervical rigidity, soreness and numbness, hemiplegia sequelae, and hemiplegia. The invention has no toxic and side effects, is safe and effective, and has good curative effect.

The problem of the present invention is to provide a compound having a superior RORγt inhibitory action, and useful as a prophylactic or therapeutic agent for psoriasis, inflammatory bowel disease, ulcerative colitis, Crohn's disease, rheumatoid arthritis, multiple sclerosis, uveitis, asthma, ankylopoietic spondylarthritis, systemic lupus erythematosus, chronic obstructive pulmonary disease or the like. The present invention relates to a compound represented by the formula (I):[wherein each symbol is as described in the DESCRIPTION] or a salt thereof, which has an RORγt inhibitory action, and useful as a prophylactic or therapeutic agent for psoriasis, inflammatory bowel disease, ulcerative colitis, Crohn's disease, rheumatoid arthritis, multiple sclerosis, uveitis, asthma, ankylopoietic spondylarthritis, systemic lupus erythematosus, chronic obstructive pulmonary disease or the like.

The invention provides an aceclofenac bi-layer osmotic pump controlled release tablet and a preparation method thereof, belongs to the technical field of medicinal preparation. The osmotic pump preparation comprises a tablet core containing aceclofenac and a semipermeable coating membrane which is coated outside the tablet core and provided with orifices, the tablet core comprises a drug layer containing aceclofenac and a boosting layer; wherein, the drug layer comprises the following components: 200mg of aceclofenac, 100mg-300mg of suspension, 10mg-50mg of osmotic stress active substance and0.5 mg-2mg of lubricant; the boosting layer comprises 50mg-150mg of sweller and 5mg-30mg of osmotic stress active substance; the semipermeable coating membrane comprises the following components: 10g-20g of semipermeable high polymer material dissolved in 500ml of acetone and 2g-5g of water soluble pore former dissolved in 20ml of distilled water and the weight of the coating membrane is 5%-10% of the tablet core weight; laser or a power drill is used to drill the orifices on the drug-containing side of the coating tablet. The invention is characterized of less dosing frequency, convenient taking way, long lasting and stable curative effect and can be used to cure pains and inflammations caused by osteoarthritis, rheumatoid arthritis, ankylosing spondylitis and the like.

The invention discloses a medicinal composition for treating rheumatism and lumbocrural pain and a preparation method thereof. The medicinal composition comprises the following raw material medicaments: common monkshood mother root, kusnezoff monkshood root, arisaema root and pinellia tuber. The medicinal composition can be prepared into clinically acceptable preparations by adding pharmaceutically conventional auxiliary materials through a conventional process, and has the effects of expelling wind and removing damness, tonifying qi and regulating blood, relaxing tendons and removing obstruction in channels and relieving swelling and stopping pain, and has the obvious treatment effects on the rheumatism, rheumatoid arthritis, ankylosing spondylitis, cervical spondylosis, protrusion of lumbar vertebral disc and the like.

The invention discloses powder for treating cervical spondylosis, intervertebral disc herniation, ankylosing spondylitis and hyperosteogeny, and belongs to the field of Chinese medicines. The powder consists of the following components: common monkshood mother root, kusnezoff monkshood root, frankincense, myrrh, aconitum pendulum busch, divaricate saposhnikovia root, yellowmouth dutchmanspipe root, spreading hedyotis herb, long-noded pit viper, pangolin scales, centipede, astragalus, wooly datchmanspipe herb, mulberry twig, white mulberry root-bark, east Asian tree fern rhizome, dragon's blood, pyrite, clematis root and liquoric root. A preparation method for the powder comprises the following steps of: crushing the medicaments into superfine powder, bagging, and soaking in distilled spirit. When the powder is used, a Chinese medicinal bag is applied to wounds and is covered by a plastic film to be sealed and fixed, and is replaced after 24 hours. The powder has the effects of softening hardness to dissipate stagnation, promoting blood circulation and removing blood stasis, dispelling wind and eliminating cold, relieving swelling and pain, drawing out pus and promoting tissue regeneration and removing obstruction in channels to relieve pain, the effective rate is 95 percent, and the cure rate is 90 percent.

The invention relates to application of ozonized oil in small surgical incisions or other wound such as mucosal ulcer, diabetic feet, cervical erosion, anal fissure, anus fistula, soft tissue injury,fall damage wound surface, recurrent wound, abscess, acne, arthritis, joint degeneration, cystitis, furunculosis, neurological disorder osteomyelitis, gangrene, ulcus cruris, synovitis, gout, sinusitis, spondylitis, scapulohumeral periarthritis, lumbocrural pain, periostitis and stomatitis. Through the modes of oral administration, intraperitoneal injection, clyster, gavage, intravenous injection,subcutaneous injection, intramuscular injection, external application, drop and suppository, the diseases can be effectively prevented and treated.

The invention discloses a traditional Chinese medicine composition. The composition is prepared from, by weight, 200-205 parts of radix rehmanniae preparata, 130-140 parts of Chinese pyrola herbs, 130-140 parts of rhzizoma drynariae, 130-140 parts of suberect spatholobus stem, 130-140 parts of cistanche deserticola, 130-140 parts of epimedium herbs and 80-90 parts of fried radish seeds. The invention further discloses a preparation method and application of the traditional Chinese medicine composition. The composition has the functions of tonifying the kidney, activating blood, diminishing inflammation and relieving the pain. The traditional Chinese medicine composition is used for hypertrophic myelitis, cervical spondylosis, calcaneal spur, proliferative arthritis and Kashin-Beck diseases. The composition further has the functions of improving mesentery circulation and promoting functional repairing of the stomach and intestines and is applied to treatment of stomach and intestine injuries and the like.

The invention discloses a preparation method of traditional Chinese medicine for treating hypertrophic spondylitis, cervical spondylosis, heel spurs, proliferative arthritis and Kashin-Beck disease. The frankincense, myrrh, Corydalis Corydalis, Nuxystigma chinensis, notoginseng and dried blood are crushed by airflow The machine crushes the extract into superfine powder a, and mixes it evenly; the turmeric, woody, solitary, and cassia twigs are enzymatically hydrolyzed to obtain a clear paste b, and the dregs are added to the four flavors of white peony root, safflower, achyranthes bidentata, and Gentiana chinensis. The supernatant c obtained by carbon dioxide supercritical extraction method, b and c are combined, concentrated to a thick paste and dried, and the extract is crushed into ultrafine powder d with a jet mill, and a and d are mixed evenly, and added to a pharmaceutically acceptable The accepted excipients are mixed and encapsulated, and the invention has the advantages of complete extraction of active ingredients, high bioavailability, good absorption, stable quality, good reproducibility and the like.

The invention relates to a traditional Chinese medicine for treating osteoarticular diseases, and a preparation method thereof. The traditional Chinese medicine for treating osteoarticular diseases is prepared through using the following raw medicines, by weight, 20-45 parts of Sevenlobed Yam Rhizome, 20-40 parts of Atractylodes lancea, 20-40 parts of white peony root, 20-40 parts of Chinese angelica, 20-40 parts of pawpaw, 20-40 parts of Millettia dielsiana, 20-40 parts of Himalayan Teasel Root, 20-40 parts of Rhizoma Corydalis, 20-40 parts of dried Rehmannia glutinosa Libosch, 20-40 parts of Chinese Taxillus Twig, 20-40 parts of Rhizoma Drynariae, 20-40 parts of Divaricate Saposhnikovia Root, 20-40 parts of Radix Stephaniae Tetrandrae, 20-40 parts of Eucommia ulmoides, 20-40 parts of Fructus Liquidambaris, 20-40 parts of Rhizoma Cibotii, 10-30 parts of Boswellia carteri, 10-30 parts of myrrh, 10-30 parts of Radix Clematidis, 5-25 parts of prepared Aconitum kusnezoffii, 5-25 parts of prepared Radix Aconiti, 10-30 parts of Ligusticum wallichii, 20-40 parts of dahurian angelica root, 20-40 parts of centipede and 20-40 parts of pangolin. The traditional Chinese medicine a beneficial effect that the traditional Chinese medicine has good treatment effects on the osteoarticular diseases, especially hydrarthrosis pains comprising pains in muscles and bones, ankylosing spondylitis, femur head necrosis and the like through the screening and the scientific matching of muscle and bone strengthening, swelling diminishing and pain relieving medicines.

The invention discloses special paste for relieving and promoting rehabilitation of bone diseases. The paste comprises, by mass, 5.6-7.8 parts of castor beans, 9.8-11.2 parts of radix angelicae, 6.7-8.9 parts of red peony root, 4.5-7.2 parts of rheum officinale, 2.3-4.5 parts of musk, 4.5-6.7 parts of momordica cochinchinensis, 7.2-9.8 parts of radix scutellariae, coptidis rhizome and cortex phellodendri, 3.1-5.2 parts of drynaria total flavonoids, 5.6-8.2 parts of earthworms, 7.5-9.4 parts of cortex cinnamomi, 5.2-8.6 parts of clove, 8.8-12.5 parts of pericarpium zanthoxyli, 2.4-7.8 parts ofcamphor, 10-16 parts of borneol and 120-150 parts of Vaseline. The paste can relieve femoral head necrosis, hyperosteogeny, cervical spondylosis, lumbar spondylosis, intervertebral disc herniation, rheumatic arthritis, ankylosing spondylitis, scapulohumeral periarthritis, traumatic injury and senile osteoarthritis, relax tendons and activating collaterals, relieve pain caused by gout, promote rehabilitation and the like.

The invention discloses an iliacus muscle oral liquid and a preparation method thereof. The iliacus muscle oral liquid comprises the components of, by weight, 27 parts of frankincense, 46 parts of myrrh, 91 parts of white peony root, 27 parts of rhizoma corydalis (processed with vinegar), 46 parts of pseudo-ginseng, 27 parts of radix aucklandiae, 46 parts of safflower carthamus, 91 parts of radix curcumae, 183 parts of radix angelicae pubescentis, 46 parts of radix achyranthis bidentatae, 183 parts of large-leaved gentian, 46 parts of cassia twig, 27 parts of resina draconis and 27 parts of semen strychni (fried). The iliacus muscle oral liquid is a pure traditional Chinese medicine composition oral liquid preparation and has the functions for hypertrophic myelitis, cervical spondylosis, heel spurs, hypertrophic arthritis, kashin-beck diseases, etc. Compared with iliacus muscle pills, iliacus muscle tablets, iliacus muscle capsules which are described in Chinese medicine ministerial standards, the iliacus muscle oral liquid has the advantages of small dosage, good taste, convenience for taking, relatively fast absorption, high bioavailability, stable quality, simple production process, etc.

The disclosure is directed to pharmaceutical products and stable liquid compositions of IL-17 antibodies and antigen-binding fragments thereof, e.g., AIN457 (secukinumab), and processes of making these pharmaceutical products and compositions. The disclosure is also directed to the use of these pharmaceutical products and liquid compositions (e.g., as part of a kit having instructions for use) for the treatment of various IL-17-mediated disorders (e.g., autoimmune disorders, such as psoriasis, ankylosing spondylitis, psoriatic arthritis, and rheumatoid arthritis).

The invention relates to the technical field of traditional Chinese medicines, and especially relates to a traditional Chinese medicinal composition for treating pains in waist, legs, muscles and bones, and a preparation method thereof. The method adopts ginseng, Pyrola calliantha, Semen Strychni, Herbal Ephedrae, Incised Notopterygium, Radix Angelicae Pubescentis, cassia twig, frankincense, Achyranthes bidentata, myrrh, Eucommia ulmoides, Rhizoma Homalomenae, peach kernels, Radix Aconiti Preparata, Veronicastrum sibiricum, Chinese angelica root, Salvia miltiorrhiza and Kadsura Pepper Stem asraw materials, and the raw materials are reasonably combined to jointly act in order to fuse beneficial effects of all the raw materials, eliminate toxic and side effects and fully show and fuse the effects of all the raw materials, so the safe and nontoxic traditional Chinese medicinal composition being able to strengthen tendons and bones, relax muscles and stimulate blood circulation and used for aching lumbus, limp legs, limb numbness, rheumatic arthralgia, hyperostosis, rheumatism, joint and muscle swelling pains, acute gout, hypertrophic spondylitis, degenerative spondylitis, arthritis,strain of lumbar muscles, sciatica, and paralysis in the hands and feet with low back pains; and the raw materials are easy to obtain.

The invention provides the use of a calcitonin in the preparation of a medicament for the treatment of an inflammatory disease or condition. The calcitonin may be selected from the group consisting of human, salmon, eel, porcine, bovine, or chicken calcitonin or a derivative, a fragment or a variant thereof. The inflammatory disease or condition may be rheumatoid arthritis (RA), juvenile rheumatoid arthritis (JRA), osteoarthritis, psoriasis, psoriatic arthritis, ankylosing spondylitis (AS), lupus erythamatosis, multiple sclerosis (MS), asthma, or immuno-suppressive therapy (e.g. post transplantation surgery). The treatment may also comprise administration of a glucocorticoid, an anti-rheumatic drug or an antibody.

The invention relates to a Chinese angelica parasitic drop pill, which is a medicinal composition for treating rheumatic arthritis, hypertrophy spondylitis, waist and knee strain, waist and legs pain, dysmenorrhea, ischialgia, and nerve cephalalgia. to provide a medicinal composition having the advantages of high biological availability, quick-speed medicine release, quick-speed effect, higher medicinal content, accurate administration dosage, low price, no acute allergic reaction or adverse effect, and facilitated transportation and carrying. The drop pill is prepared from the extract containing Chinese angelica and mistletoe, and medicinal carrying agent as the base material.

The present invention relates generally to methods for diagnosing the presence or the risk of development or the therapy control of spondyloarthritis (Spa), in particular, of ankylosing spondylitis (AS) and undifferentiated spondyloarthritis in a subject, in particular in mammals. In addition, the present invention relates to test kits for use in the diagnosis of the presence or the risk of development, or for the therapy control of Spa, like AS and undifferentiated spondyloarthritis, in a subject. In particular, the present invention relates to a method for diagnosing the presence or the risk of development, or for the therapy control of Spa, like AS and undifferentiated spondyloarthritis, in a subject analysing for the presence of autoantibodies against CD74 and / or IKBKB in a subject. The presence of autoantibodies against CD74 and / or IKBKB is indicative for the presence or the risk of development, or for the therapy control of Spa, like AS and undifferentiated spondyloarthritis. In particular, detection of the presence of autoantibodies against CD74 and / or IKBKB allows early diagnosis of Spa, in particular, AS and undifferentiated spondyloarthritis.

The invention discloses a medicinal liquor special for relieving bone diseases and promoting rehabilitation. The medicinal liquor comprises 28-50 parts of radix angelicae sinensis, 22-34 parts of eucommia ulmoides, 17.8-28.5 parts of radix zanthoxyli, 26.8-34.5 parts of radix salviae miltiorrhizae, 21-33 parts of caulis spatholobi, 24.5-35.6 parts of tendril-leaved fritillary bulb, 31.5-42 parts of licorice root and 1100-1300 parts of baijiu. The medicinal liquor can relieve bone disease pains, promote rehabilitation, activate blood circulation to remove stasis and promote blood circulation and can relieve pains caused by the osteonecrosis of the femoral head, hyperostosis, cervical spondylosis, lumbar spondylosis, protrusion of intervertebral disc, rheumatic arthritis, ankylosing spondylitis, scapulohumeral periarthritis, traumatic injuries, senile osteoarthritis and gout, stimulate the blood circulation and relax muscles and joints, and promote rehabilitation.

The invention discloses an anti-osteoproliferation preparation for treating orthopedic diseases, a preparation method and a quality control method thereof, and belongs to the technical field of traditional Chinese medicines. It is mainly composed of Rehmannia glutinosa, steamed cistanche, salted dog ridge, salted Ligustrum lucidum, epimedium, chicken blood vine, fried radish seeds, drynaria, and achyranthes plus appropriate amount of accessories, respectively made into injection preparations and Various oral preparations such as dripping pills, micro-pills, dispersible tablets, etc., also provide the content determination and identification methods of this preparation; it is mainly used for the treatment of proliferative spondylitis, including hypertrophic thoracic spondylitis, hypertrophic lumbar spondylitis, cervical syndrome, Bone spurs and other diseases, the technology is reasonable, the quality is controllable, it is convenient to take, and the appearance is beautiful and clean.

The present invention relates generally to methods for diagnosing the presence or the risk of development or the therapy control of spondyloarthritis (Spa), in particular, of ankylosing spondylitis (AS) and undifferentiated spondyloarthritis in a subject, in particular in mammals. In addition, the present invention relates to test kits for use in the diaposis of the presence or the risk of development, or for the therapy control of Spa, like AS and undifferentiated spondyloarthritis, in a subject. In particular, the present invention relates to a method for diagnosing the presence or the risk of development, or for the therapy control of Spa, like AS and undifferentiated spondyloarthritis, it a subject analysing for the presence of autoantibodies against CD74 and / or IKBKB in a subject. The presence of autoantibodies against CD74 and / or IKBKB is indicative for the presence or the risk of development, or for the therapy control of Spa, like AS and undifferentiated spondyloarthritis. In particular, detection of the presence of autoantibodies against CD74 and / or IKBKB allows early diagnostic of Spa, in particular, AS and undifferentiated spondyloarthritis.

The invention discloses a sinomenine vesicle and a preparation method thereof, a preparation containing the sinomenine vesicle and a preparation method of the preparation, which belong to the field of medicament preparations. The sinomenine vesicle is prepared from sinomenine, a nonionic surfactant and an additive. The sinomenine vesicle is preferably prepared into external gel. A sinomenine transdermal administration external preparation has a unique advantage to the medicament. Due to the application of a novel vesicle administration system, transdermal absorption of the medicament is improved, and a clinical curative effect is enhanced. The sinomenine vesicle can be used for treating rheumatism, rheumatoid arthritis, a glomerular disease, hyperosteogeny, spondylitis, arrhythmia, systemic lupus erythematosus, a heroin addict withdrawal symptom and the like.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine patch with pulling, cutting and blocking effects and a preparation method thereof. The raw material of the traditional Chinese medicine patch comprises the following bulk drugs: processed nux vomica, bark of himalayan coralbean, rhizoma curculiginis, pawpaw, safflower, radix cyathulae, root of kudzu vine, rhizoma cibotii, cassia twig, radix aconiti preparata, prepared kusnezoff monkshood root, cortex acanthopanacis, caulis spatholobi, sandalwood piece, dalbergia wood piece, ligusticum wallichii, asarum, lycopodium clavatum, angelica sinensis, astragalus membranaceus, ephedra, notopterygium root, radix angelicae pubescentis and gentiana macrophylla. The traditional Chinese medicine patch provided by the invention can dry the cold-damp environment around an organism, so that cold-damp foul qi cannot attack people, the way of wind-cold-damp evil invading skin is blocked, the traditional Chinese medicine application has relatively strong'pulling and cutting 'effects, and the'blocking' is added, so that the traditional Chinese medicine idea of 'prevention before disease, prevention and change after disease and prevention and recovery after epidemic' is comprehensively embodied. The traditional Chinese medicine patch has the functions of expelling wind-damp, clearing and activating the channels and collaterals, relieving swelling and pain and promoting blood circulation to remove blood stasis, and the total effective rate on rheumatic arthritis, spondylitis, sciatica and lumbar muscle strain reaches 94%.

The invention provides antibodies or binding fragments thereof directed against citrulline-containing epitopes. The antibodies or binding fragments thereof of the invention can be used in therapy, for example in the treatment or prevention of Neutrophil Extracellular Trap (NET)-associated pathologies. The antibodies or binding fragments thereof of the invention can be used in the treatment or prevention of NET-associated pathologies such as systemic lupus erythematosus (SLE), lupus, sepsis, vasculitis, inflammatory arthritis, rheumatoid arthritis and osteoarthritis, psoriasis, Alzheimer's disease, autoimmune hepatitis, juvenile idiopathic arthritis, Sjögren's disease, Anti-phospholipid Syndrome, Bechet's disease, spondylitis, spondyloarthropathy, multiple system atrophy, Parkinson's disease, Lewy body dementia asthma, allergic rhinovirus exacerbated asthma, allergic asthma, cystic fibrosis, fibrosis and idiopathic pulmonary fibrosis, dry eye disease, uveitis, nongranulomatous uveitis, granulomatous uveitis, dermatitis, atopic dermatitis, COPD, bronchitis, or other NET-associated pathologies such as wound healing in diabetes, cancer, cancer metastasis, and transplant organ health in vivo or ex vivo. The invention also provides pharmaceutical compositions and methods for treating or preventing NET-associated pathologies such as SLE, lupus, sepsis, vasculitis, inflammatory arthritis, rheumatoid arthritis and osteoarthritis, psoriasis, Alzheimer's disease, autoimmune hepatitis, juvenile idiopathic arthritis, Sjögren's disease, Anti-phospholipid Syndrome, Bechet's disease, spondylitis, spondyloarthropathy, multiple system atrophy, Parkinson's disease, Lewy body dementia asthma, allergic rhinovirus exacerbated asthma, allergic asthma, cystic fibrosis, fibrosis and idiopathic pulmonary fibrosis, dry eye disease, uveitis, nongranulomatous uveitis, granulomatous uveitis, dermatitis, atopic dermatitis, COPD, bronchitis, or other NET-associated pathologies such as wound healing in diabetes, cancer, cancer metastasis, and transplant organ health in vivo or ex vivo.

The present invention relates to a biomarker and target for diagnosis, prognosis and treatment of ankylosing spondylitis (AS). The present invention also relates to a method for producing an animal model for AS, an animal model produced therefrom, and a method for screening for an agent pharmaceutically active in the treatment of AS using such animal model.

The invention discloses a bone moxibustion herbal formula which comprises the following components in parts by weight: 6-8 parts of ilex ficoidea, 1-2 parts of aechynanathus austroyunna-nensis, 1-1.5 parts of boston ivy, 1-2 parts of treebine stem, 1-2.5 parts of stem of climbing etada, 1-2.5 parts of Codariocalyx motorius, 1-1.5 parts of Dayaoye, 1-2 parts of radix zanthoxyli, 1-2.5 parts of codonopsis pilosula and cortex phellodendri, 1-3 parts of fructus rosae laevigatae, 6-7 parts of Ziqiangye and 0.7-1.5 parts of other traumatic injury medicines. Leaves of ilex ficoidea, leaves of aechynanathus austroyunna-nensisand stems and leaves of boston ivyare taken as the components. The preparation process is simple, the preparation process is environment-friendly and pollution-free, the herbal formula has good functions of diminishing inflammation and swelling, relieving pain and dissipating blood stasis, liquor is used for blending, time and labor are saved, materials are cheap, the medicine can better enter the body of a patient under the volatilization of alcohol, the treatment effect is better guaranteed, and great convenience is brought for the treatment work. Longan leaves are added, so that the herbal formula has a remarkable treatment effect on diseases such as cervical vertebra hyperosteogeny, lumbar vertebra hyperosteogeny, lumbar disc herniation, ankylosing spondylitis, rheumatoid arthritis, sciatic nerve injury, traumatic injury and the like.

Described are novel heterocyclic compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites and prodrugs thereof. These compounds are useful in the treatment of immunological diseases, inflammation, pain disorder, rheumatoid arthritis,osteoporosis,multiple myeloma,uveititis,acute and chronic myelogenous leukemia,atherosclerosis,cancer,cachexia,ischemic-induced cell damage,pancreatic beta cell destruction,osteoarthritis,rheumatoid spondylitis,gouty arthritis,inflammatory bowel disease,ARDS,psoriasis,Crohn's disease,allergic rhinitis,ulcerative colitis,anaphylaxis,contact dermatitis,muscle degeneration,asthma,COPD,bone resorption diseases,multiple sclerosis,sepsis,septic shock,toxic shock syndrome and fever. More particularly these compounds are useful as PDE4 inhibitors and are useful for treating PDE4 mediated diseases.