A biomarker and target for diagnosis, prognosis and treatment of ankylosing spondylitis

A technology for spondylitis and stiffness, which can be applied in microbes, disease diagnosis, gene therapy, etc., and can solve problems such as the unknown role of mesenchymal stem cells

Pending Publication Date: 2022-01-14
台湾佛教慈济医疗基金会 +1
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Problems solved by technology

Although it has been reported that the osteogenesis of mesenchymal stem cells (MSCs) derived from patients with ankylosing spondylitis (AS) is altered 13,14 , but the roles of mesenchymal stem cells (MSCs) in osteophyte lesions and underlying genetic pathways are mostly unknown

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  • A biomarker and target for diagnosis, prognosis and treatment of ankylosing spondylitis
  • A biomarker and target for diagnosis, prognosis and treatment of ankylosing spondylitis
  • A biomarker and target for diagnosis, prognosis and treatment of ankylosing spondylitis

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[0108] 1. Materials and methods

[0109] 1.1 Human subjects

[0110] All donors provided written informed consent before sampling in accordance with the Declaration of Helsinki. The research protocol was approved by the Research Ethics Committee of Taipei Tzu Chi Hospital, the Buddhist Tzu Chi Medical Foundation, Taipei Veterans General Hospital, Taiwan's "Academia Sinica" (all in Taiwan, China) and the Royal National Rheumatology Hospital of the United Kingdom.

[0111] Bone marrow (BM) samples obtained for isolation of mesenchymal stem cells from patients with ankylosing spondylitis (AS) undergoing spinal osteotomy (A1, A2, A3) and non-antkylosing spondylitis controls (C1, C2, C3) (MSCs). All bone marrow donors used for the isolation of mesenchymal stem cells (MSCs) were Chinese Taiwanese. In addition, two independent cohorts were recruited to investigate predictive peripheral blood markers in high-risk ankylosing spondylitis (AS) patients prone to radiographic progressio...

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Abstract

The present invention relates to a biomarker and target for diagnosis, prognosis and treatment of ankylosing spondylitis (AS). The present invention also relates to a method for producing an animal model for AS, an animal model produced therefrom, and a method for screening for an agent pharmaceutically active in the treatment of AS using such animal model.

Description

[0001] related application [0002] This application claims the benefit of U.S. Provisional Application No. 62 / 696,020, filed July 10, 2018, under Section 119 of the United States Patent Act (35 U.S.C. §119), the entire contents of which are incorporated herein by reference. technical field [0003] The invention relates to a biomarker and target for diagnosis, prognosis evaluation and treatment of ankylosing spondylitis (AS). The present invention also relates to a method for producing an animal model of ankylosing spondylitis (AS), the animal model produced therefrom, and the use of this animal model to screen a pharmaceutically active drug in the treatment of ankylosing spondylitis (AS). The method of medicine. Background technique [0004] Ankylosing spondylitis (AS) is a chronic arthritis characterized by inflammatory spondylitis, peripheral arthritis, and osteosynthesis. Typically, it occurs in young adult males and is strongly associated with human leukocyte antigen...

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Application Information

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IPC IPC(8): C12N5/06C12N9/16
CPCC12N9/16A61K48/00A61P19/02C12N15/1137C12N2310/14G01N2800/102G01N33/5088G01N2800/52C12Q1/42C12N2740/16043C12N2310/531A61K31/429A61K31/663A61K45/06C12Q1/6816C12Q1/686C12Y301/03001G01N33/5091G01N33/573G01N33/6848G01N2333/916G01N2800/50G01N2800/7095A01K67/027A61K49/0008
Inventor 林国仪洪士杰刘津秀
Owner 台湾佛教慈济医疗基金会
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