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Hyperosteogeny-resisting formulation for treating orthopaedics disease, preparation method and quality control method thereof

A technology for anti-bone hyperplasia and orthopedic diseases. It is applied in bone diseases, medical preparations containing active ingredients, and pharmaceutical formulas. It can solve the problems of increasing stability, poorly soluble components, and poor bioavailability, so as to achieve increased stability. , Improve bioavailability and high pass rate

Active Publication Date: 2009-11-04
GUIZHOU YIBAI WOMAN BIG PHARMA FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The object of the present invention is to: provide a kind of anti-bone hyperplasia preparation for the treatment of orthopedic diseases and its preparation method; The present invention is aimed at the prior art, prepares the preparation into pellets and dispersible tablets, which has the characteristics of good disintegration, and solves the problem of The problem of bioavailability of ingredients with poor solubility is especially suitable for the elderly and patients who have difficulty swallowing tablets or capsules. The coating technology is used in the preparation process, which is conducive to the stability of ingredients; there are also dripping pills, which can cover up the drugs Bad taste and smell, and play the role of increasing stability and improving bioavailability, so as to overcome the problems existing in the prior art

Method used

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  • Hyperosteogeny-resisting formulation for treating orthopaedics disease, preparation method and quality control method thereof
  • Hyperosteogeny-resisting formulation for treating orthopaedics disease, preparation method and quality control method thereof
  • Hyperosteogeny-resisting formulation for treating orthopaedics disease, preparation method and quality control method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0111] Example 1 of the present invention: Rehmannia glutinosa 31.8g, steamed Cistanche 21.3g, salted dog spine 21.3g, salted Ligustrum lucidum 10.5g, epimedium 21.3g, Caulis Spatholobus 21.3g, fried radish seed 10.5g, Drynaria 21.3g, Achyranthes bidentata 21.3g

[0112] Take rehmannia glutinosa, steamed cistanche, salted dog spines, salted privet privet seeds, epimedium, Caulis Spatholobus, fried radish seeds, rhizoma drynariae, and achyranthes bidentata, add water and boil twice, the first time for 2 hours, and the second time Second time for 1.5 hours, combine the decoction, filter, concentrate the filtrate to a thick paste with a relative density of 1.30 at 50°C, dry, pulverize, add polyethylene glycol 4000 according to extract powder: matrix = 1:1.5, mix evenly, and heat to 80-90°C, after it is completely melted, transfer it to a liquid storage bottle, keep warm at 70-75°C, drop into simethicone oil at 20-30°C, the drop distance is 4-6cm, and the drop rate is 25-30 drops / ...

Embodiment 2

[0113] Example 2 of the present invention: Rehmannia glutinosa 31.8g, steamed cistanche 21.3g, salted dog ridge 21.3g, salted privet privet 10.5g, epimedium 21.3g, milletanus 21.3g, fried radish seed 10.5g, Drynaria 21.3g, Achyranthes bidentata 21.3g

[0114] Take rehmannia glutinosa, steamed cistanche, salted dog spines, salted privet privet seeds, epimedium, Caulis Spatholobus, fried radish seeds, rhizoma drynariae, and achyranthes bidentata, add water and boil twice, the first time for 2 hours, and the second time 1.5 hours for the second time, combine the decoction, filter, concentrate the filtrate to a thick paste with a relative density of 1.30 at 50°C, dry, pulverize, add 8% cross-linked polyvinylpyrrolidone, 10% microcrystalline cellulose, mix well, and add the concentration 25% ethanol, passed through a 24-mesh sieve for granulation, dried at 60°C for 2 hours, passed through a 24-mesh sieve for granulation, and then mixed with 0.2% magnesium stearate to obtain a table...

Embodiment 3

[0115] Example 3 of the present invention: Rehmannia glutinosa 31.8g, steamed cistanche 21.3g, salted dog ridge 21.3g, salted privet privet 10.5g, epimedium 21.3g, milletanus 21.3g, fried radish seed 10.5g, Drynaria 21.3g, Achyranthes bidentata 21.3g

[0116] Take rehmannia glutinosa, steamed cistanche, salted dog spines, salted privet privet seeds, epimedium, Caulis Spatholobus, fried radish seeds, rhizoma drynariae, and achyranthes bidentata, add water and boil twice, the first time for 2 hours, and the second time The second time is 1.5 hours, the decoction is combined, filtered, the filtrate is concentrated to a thick paste with a relative density of 1.30 at 50°C, dried, crushed, and citric acid with a ratio of 1:2 to the main drug is added, mixed evenly, and anhydrous Use ethanol as a wetting agent to make soft materials, pass through a 24-mesh sieve to obtain wet granules, then put them into a semi-automatic coating granulator with a rotation speed of 80-100r / min, prepar...

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Abstract

The invention discloses an anti-osteoproliferation preparation for treating orthopedic diseases, a preparation method and a quality control method thereof, and belongs to the technical field of traditional Chinese medicines. It is mainly composed of Rehmannia glutinosa, steamed cistanche, salted dog ridge, salted Ligustrum lucidum, epimedium, chicken blood vine, fried radish seeds, drynaria, and achyranthes plus appropriate amount of accessories, respectively made into injection preparations and Various oral preparations such as dripping pills, micro-pills, dispersible tablets, etc., also provide the content determination and identification methods of this preparation; it is mainly used for the treatment of proliferative spondylitis, including hypertrophic thoracic spondylitis, hypertrophic lumbar spondylitis, cervical syndrome, Bone spurs and other diseases, the technology is reasonable, the quality is controllable, it is convenient to take, and the appearance is beautiful and clean.

Description

technical field [0001] The invention relates to an anti-bone hyperplasia preparation for treating orthopedic diseases, a preparation method and a quality control method thereof, and belongs to the technical field of traditional Chinese medicines. technical background [0002] Osteoarthritis is also known as hypertrophic osteoarthritis, degenerative arthritis, hypertrophic arthritis, osteoarthritis, etc. It is a general term for degenerative bone and joint disease. This disease is an ancient disease. When human beings are engaged in production and life activities, the load-bearing joints, especially the parts that bear the most stress, are prone to damage changes of articular cartilage, joint deformation and bone hyperplasia at the joint edge, causing bone hyperplasia. disease. Osteoarthritis is a common disease and frequently-occurring disease among middle-aged and elderly people. The incidence rate tends to increase with age. In recent years, due to the popularization of ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/804A61K9/00A61P19/10
Inventor 于文风
Owner GUIZHOU YIBAI WOMAN BIG PHARMA FACTORY
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