Aceclofenac bi-layer osmotic pump controlled release tablets and preparation method thereof
An osmotic pump controlled release and aceclofenac technology, which is applied in the directions of pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc. clinical treatment and other issues
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Embodiment 1
[0023] Tablet prescription:
[0024] Drug-containing layer
[0025] Aceclofenac 200mg
[0026] Polyoxyethylene 250mg
[0027] Sucrose 50mg
[0029] booster layer
[0030] Polyoxyethylene 70mg
[0031] Lactose 15mg
[0032] Semi-permeable coating film prescription:
[0033] Cellulose acetate 20g
[0034] Polyethylene glycol 4g
[0035] Solvent prescription for dissolving film coating material:
[0036] Acetone 500mL
[0037] Distilled water 20mL
[0038] Preparation Process:
[0039] Pass the prescribed amount of medicine, polyoxyethylene with a molecular weight of 300,000, sucrose, and magnesium stearate through an 80-mesh sieve, and mix evenly; Punch No. 11 twice and pressurize to get the tablet core. Dissolve cellulose acetate and polyethylene glycol wi...
Embodiment 2
[0041] Tablet prescription:
[0042] Drug-containing layer
[0043] Aceclofenac 200mg
[0044] Sodium Alginate 200mg
[0047] booster layer
[0048] Polyoxyethylene 90mg
[0050] Semi-permeable coating film prescription:
[0051] Ethyl cellulose 20g
[0052] Polyethylene glycol 4g
[0053] Solvent prescription for dissolving film coating material:
[0054] Acetone 500mL
[0055] Distilled water 20mL
[0056] Preparation Process:
[0057]Pass the prescribed amount of medicine, sodium alginate, sodium chloride, and magnesium stearate through an 80-mesh sieve, and mix evenly; pass the prescribed amount of polyoxyethylene and sodium chloride with a molecular weight of 4,00...
Embodiment 3
[0059] Tablet prescription:
[0060] Drug-containing layer
[0061] Aceclofenac 200mg
[0062] Gum Arabic 150mg
[0063] Mannitol 10mg
[0064] Micronized silica gel 2mg
[0065] booster layer
[0066] Polyoxyethylene 140mg
[0067] Lactose 25mg
[0068] Semi-permeable coating film prescription:
[0069] Cellulose acetate 12g
[0070] Acrylic 6
[0071] Polyethylene glycol 4g
[0072] Solvent prescription for dissolving film coating material:
[0073] Acetone 500mL
[0074] Distilled water 20mL
[0075] Preparation Process:
[0076] Pass the prescribed amount of medicine, gum arabic, mannitol, and micropowdered silica gel through 80 mesh sieves, and mix evenly; pass the prescribed amount of polyoxyethylene and lactose with a m...
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