Medical application of ozonized oil for promoting healing of wound and inflammation

A technique for ozonating oil and wounds, applied in the field of medicine, can solve problems such as unclear specific mechanism and difficulty in ensuring the effective concentration of gas entering the body

Inactive Publication Date: 2018-10-16
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The function of ozone gas may be realized through the following three ways: (1), ozone generates substances similar to active oxygen through biochemical reactions in the body (hydroxyl radical OH - , superoxide anion O 2 - etc.), extensively affects the redox system of the body; (2), ozone can cause the aggregation of endothelial progenitor cells and promote the generation of nitric oxide (NO), which can relax blood vessels; (3), ozone can induce bone marrow stem cells to At the site of vascular injury, it promotes the repair and reconstruction of damaged blood vessels, but the specific mechanism is still unclear
[0003] There are many defects in the above route of administration: contact with too many substances along the way, it is difficult to ensure the effective concentration of gas entering the body
However, the form of enteric-coated capsules made of ozonated oil enters the body through direct oral administration to produce efficacy, and there is no report yet

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Embodiment 1 ozonated olive oil preparation

[0016] 1. Preparation of ozone gas. The invention adopts medical oxygen to prepare ozone gas through an ozone generator.

[0017] It is selected from the DRO3-A ozone machine (power≦55W) designed and produced by Xi'an Derun Biotechnology Co., Ltd.

[0018] 2. The whole process of preparing ozonated oil and ozonated oil enteric-coated capsules must be carried out at 20-25°C to ensure that the ozonated oil does not undergo pyrolysis.

[0019] 3. Put 3kg of olive oil into the reactor; 3 / h flow rate was added, and the total reaction time was 20 hours. After the reaction is over, the residual gas is inactivated.

[0020] 4. The obtained ozonated olive oil has a concentration of 40 mg / L and can be stored stably for ten months at 25°C.

Embodiment 2

[0021] Example 2 Preparation of ozonated olive oil enteric-coated capsules

[0022] Preparation of ozonated olive oil enteric-coated capsules.

[0023] (1) Preparation of capsule material: Weigh water, gelatin, glycerin and glutinous rice flour or starch into the glue tank according to the weight ratio of 3:3:1:1. When the temperature is 60°C, add water, add water for 10 minutes, feel slightly hot when touched, start to add glycerin, stir for 2 minutes, take 2 times from the bottom of the glue tank, pour it back into the glue tank, quickly add gelatin, and stir for 2 minutes After stirring, the temperature was set to 60°C, and the mixture was allowed to stand for 8 hours to remove air bubbles.

[0024] (2) Ozonized olive oil enteric-coated capsules were prepared by compression method, with a capacity of 0.25 mL.

[0025] Capsules were made at room temperature at 22°C, the thickness of the rubber was 0.7mm, and the capacity was 0.25mL. The soft capsules were cooled in a tumbl...

Embodiment 3

[0026] Preparation of enteric-coated capsules of embodiment 3 ozonated olive oil, soybean oil and peanut oil mixed oil

[0027] 1. Preparation of ozone gas. The invention adopts medical oxygen to prepare ozone gas through an ozone generator.

[0028] It is selected from the DRO3-A ozone machine (power≦55W) designed and produced by Xi'an Derun Biotechnology Co., Ltd.

[0029] 2. The whole process of preparing ozonated oil and ozonated oil enteric-coated capsules must be carried out at 20-25°C to ensure that the ozonated oil does not undergo pyrolysis.

[0030] 3. Put 1kg of olive oil, 1kg of soybean oil and 1kg of peanut oil into the reaction kettle; 3 / h flow rate was added, and the total reaction time was 20 hours. After the reaction is over, the residual gas is inactivated.

[0031] 4. The concentration of the obtained ozonated mixed oil is 40mg / L, and it can be stored stably for ten months at 25°C.

[0032] 5. Preparation of ozonated mixed oil enteric-coated capsules. ...

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PUM

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Abstract

The invention relates to application of ozonized oil in small surgical incisions or other wound such as mucosal ulcer, diabetic feet, cervical erosion, anal fissure, anus fistula, soft tissue injury,fall damage wound surface, recurrent wound, abscess, acne, arthritis, joint degeneration, cystitis, furunculosis, neurological disorder osteomyelitis, gangrene, ulcus cruris, synovitis, gout, sinusitis, spondylitis, scapulohumeral periarthritis, lumbocrural pain, periostitis and stomatitis. Through the modes of oral administration, intraperitoneal injection, clyster, gavage, intravenous injection,subcutaneous injection, intramuscular injection, external application, drop and suppository, the diseases can be effectively prevented and treated.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the use of ozonated oil in the treatment of wounds and inflammations and the combined use of medicines for treating wounds and inflammations. Background technique [0002] Velio Bocci in the book "Ozone Therapy" outlines the use of low doses of ozone gas to perform many beneficial functions without side effects, namely ozone therapy (see "Oxygen-Ozone Therapy" by Velio Bocci, Peking University Medical Press , 2004). Ozone therapy can be achieved through a variety of routes of administration, and produce different effects for different diseases. Ozonated oil is used externally as an antibacterial agent, deodorant and in the treatment of skin diseases such as bedsores and ulcers. Therefore, ozone is known to have oxidizing and antibacterial effects. The ozonated oil was directly administered into the stomach for the treatment of gastritis caused by Helicobacter pylo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/00A61K9/48A61K9/02A61P17/02A61P3/10A61P9/14A61P15/00A61P1/00A61P19/04A61P17/10A61P19/02A61P29/00A61P13/10A61P25/00A61P19/08A61P19/06A61P11/02A61P1/02
CPCA61K9/0019A61K9/0031A61K9/0053A61K9/025A61K9/4808A61K9/4816A61K9/4858A61K33/00A61K47/44
Inventor 李新平侯建生周博
Owner NORTHWEST A & F UNIV
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