Nifuratel-nysfungin gel and preparation method thereof

A technology of nifuratel and nystatin, which is used in pharmaceutical formulations, medical preparations containing active ingredients, organic active ingredients, etc., can solve problems such as many adverse reactions, low bioavailability, and large side effects, and achieve maintenance The effect of vaginal physiological environment, promotion of disease recovery, and safe use

Active Publication Date: 2012-07-18
程雪翔
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The present invention aims at the problems that existing various medicines for treating gynecological vaginal diseases have relatively large side effects, many adverse reactions, relatively poor re

Method used

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  • Nifuratel-nysfungin gel and preparation method thereof
  • Nifuratel-nysfungin gel and preparation method thereof
  • Nifuratel-nysfungin gel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Add 0.2g of carbomer to an appropriate amount of water under high-speed stirring to form a carbomer solution; dissolve 2g of propylene glycol in an appropriate amount of water and mix evenly with the carbomer solution, then add 0.1g of ethylparaben and 0.4g of triethanolamine , to obtain a gel matrix; 4g of nifuratel, 0.08 million IU nystatin was dissolved in 2.3g of ethanol, adding an appropriate amount of water, adding it into the gel matrix under constant stirring, and stirring evenly to obtain nifurate Nystatin Gel. The total mass of water used in this example is 60g.

Embodiment 2

[0044] First, 0.04g of sodium bisulfite and 0.04g of disodium edetate were dissolved in water to form a solution, and 1.08g of carbomer was added to the above solution under high-speed stirring to form a carbomer solution; 6.3g of propylene glycol was dissolved in Appropriate amount of water, and mix it with carbomer solution evenly, then add 0.35g ethylparaben and 0.75g triethanolamine to obtain a gel matrix; dissolve 12g nifuratel and 0.48 million IU nystatin in 6g ethanol , add an appropriate amount of water, add it into the gel matrix under continuous stirring, and then get the nifuratel-nystatin gel after stirring evenly. The total mass of water used in this example is 80g.

Embodiment 3

[0046] Add 2.3g of carboxyethyl cellulose to an appropriate amount of water under high-speed stirring to form a carboxyethyl cellulose solution; dissolve 12g of propylene glycol in an appropriate amount of water, and mix evenly with the carboxyethyl cellulose solution, then add 0.48g of paraben ethyl ester, propylparaben, and 3g ethylenediamine to obtain a gel matrix; dissolve 3g nifuratel and 0.18 million IU nystatin in 2g ethanol, add an appropriate amount of water, and add it to the gel under constant stirring In the matrix, the nifuratel-nystatin gel is obtained after stirring evenly. The total mass of water used in this example is 93g.

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Abstract

The invention relates to a nifuratel-nysfungin gel and a preparation method of the nifuratel-nysfungin gel. The gel is prepared by nifuratel, nysfungin, hydrogel matrix and other auxiliary materials. According to the invention, the pharmaceutical ingredients are fully dissolved and evenly mixed in the gel matrix, and the pharmaceutical ingredients are fully contacted with the vaginal wall, so that the bacteriostasis of the medicine is fully exerted, and the nifuratel-nysfungin gel is safe and comfortable to use without foreign body sensation and greasy feeling. The nifuratel-nysfungin gel canbe used for treating vulva and vaginal infections and vaginal mixed infection caused by bacteria, trichomonas and candida, thus effectively maintaining the physiological environment of the vagina, providing the survival condition suitable for vaginal beneficial bacterium group and promoting disease recovery.

Description

technical field [0001] The invention belongs to the technical field of chemical pharmacy, and in particular relates to a nifuratel-nystatin gel and a preparation method thereof. Background technique [0002] Gynecological vaginal diseases are common and frequently-occurring diseases in women, and trichomonas vaginitis, bacterial vaginosis and vulvovaginal candidiasis are more typical gynecological vaginal diseases, and their incidence rates are increasing year by year. Vaginitis is an inflammation of the vaginal mucosa and submucosal connective tissue, and is a common disease in gynecological clinics. For normal healthy women, due to their anatomical and biochemical characteristics, the vagina has a natural defense function against the invasion of pathogens. When the natural defense function of the vagina is destroyed, pathogens are easy to invade and cause vaginal inflammation. Young girls and postmenopausal women may suffer from estrogen deficiency. , The vaginal epitheli...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K31/422A61K9/06A61P15/02A61P31/04A61P31/10A61P33/02
Inventor 程雪翔
Owner 程雪翔
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