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Diarylhydantoin compounds

一种化合物、氨基甲酰基的技术，应用在二芳基乙内酰脲化合物领域，能够解决耗费时间等问题

Inactive Publication Date: 2012-07-18
RGT UNIV OF CALIFORNIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, for each compound prepared, time-consuming methods for determining the antagonistic and agonistic properties of the compound must be determined
That is, there is no method to accurately predict the properties of the relevant therapeutic prostate cancer from the chemical structure of the compound alone

Method used

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  • Diarylhydantoin compounds
  • Diarylhydantoin compounds
  • Diarylhydantoin compounds

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Embodiment Construction

[0131] The present invention includes compounds having the formula:

[0132]

[0133] Wherein X is selected from trifluoromethyl and iodine, wherein W is selected from O and NR5, wherein R5 is selected from the following groups: H, methyl and

[0134]

[0135] wherein D is S or O, and E is N or O, and G is alkyl, aryl, substituted alkyl or substituted aryl; or D is S or O and E-G together are C1-C4 lower alkyl,

[0136] wherein R1 and R2 together contain 8 or less carbon atoms and are selected from the group consisting of alkyl, substituted alkyl including haloalkyl, and, together with the carbon atoms to which they are attached, cycloalkyl or substituted cycloalkyl,

[0137] Wherein R3 is selected from the following groups: hydrogen, halogen, methyl, C1-C4 alkoxy, formyl, haloacetoxy, trifluoromethyl, cyano, nitro, hydroxyl, phenyl, amino, methyl Carbamoyl, methoxycarbonyl, acetylamino, methylsulfonylamino, methylsulfonyl, 4-methylsulfonyl-1-piperazinyl, piperazinyl, ...

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Abstract

The present invention relates to diarylhydantoin compounds, including diarylthiohydantoins, and methods for syntheszing them and using them in the treatment of hormone refractory prostate cancer.

Description

[0001] The present invention is a divisional application of China's invention application (application date: March 29, 2006; application number: 200680025545.1; invention name: "diarylhydantoin compound"). technical field [0002] The present invention relates to diarylthiohydantoins, including diarylthiohydantoins, methods of synthesizing them and their use in the treatment of hormone refractory prostate cancer. This application claims priority to US Provisional Application Serial Nos. 60 / 756,552, 60 / 750,351 and 60 / 680,835, which are hereby incorporated by reference. Background of the invention [0003] Prostate cancer is the most common cancer among Western men and the second leading cause of cancer death. When the cancer is localized, the disease can be cured with surgery or radiation. However, 30% of these cancers recur with distant metabolic disease and other conditions that are diagnostically serious. Severe disease is treated with castration and / or administration of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D233/86C07D233/88
CPCC07D233/84C07D233/88C07D233/72C07D233/86C07C255/46C07C255/58C07C317/36C07C331/28C07D235/02C07D295/26C07D471/10A61P13/08A61P15/00A61P35/00A61P43/00A61P5/26A61P5/28A61K31/4184A61P5/16A61K31/4166A61K31/4164A61K31/4178C07D403/10
Inventor 查尔斯.L.索耶斯迈克尔.E.琼查利.D.陈萨梅迪.奥克德里克.韦尔斯比克里斯.特兰约翰.旺格维帕特刘东沅
Owner RGT UNIV OF CALIFORNIA
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