Device for acquiring multispectral microscopic image

A multi-spectral image acquisition device technology, applied in the field of multi-spectral microscopic image acquisition devices, can solve the problems of reduced spatial resolution, inability to replace at will, and poor scalability, and achieve good scalability, easy implementation, and wavelength replaceable effect

Active Publication Date: 2014-02-26
MOTIC CHINA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Current multispectral microscopes generally use gratings, electrically tunable filter devices (LCTF or AOTF), and color filters to obtain spectral information. For example, Chinese patent ZL200410017031.4 uses gratings to obtain spectral information. The optical filter device obtains spectral information, although both methods can obtain continuous microscopic images with high spectral resolution, but the cost is relatively high
[0004] Patent WO2008074019A2 discloses a method using a color filter array, which can obtain multispectral data of a limited number of bands. Although the structure is compact, the spatial resolution will be reduced; the more bands, the more the spatial resolution will be reduced, and After the color filter array is determined, its spectral band is also determined, it cannot be replaced at will, it can only be used for special use, and the expandability is not strong

Method used

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  • Device for acquiring multispectral microscopic image
  • Device for acquiring multispectral microscopic image
  • Device for acquiring multispectral microscopic image

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Such as figure 1 As shown, a multi-spectral image acquisition device includes a computer 6, a microscope 1, a camera 5, and an adjustable band-pass filter 2, and the microscope 1, camera 5, and adjustable band-pass filter 2 are the same Optical axis setting; the adjustable bandpass filter 2 is installed between the microscope 1 and the camera 5, and fixed on the motor 3, and the angle between the adjustable bandpass filter 2 and the optical axis is changed under the drive of the motor 3, that is, the incident The motor 3 is electrically connected to the controller 4, the controller 4 and the camera 5 are electrically connected to the computer 6, and the computer 6 controls the synchronous work of the camera 5 and the motor 3.

[0022] The image of the section enlarged by the microscope 1 is filtered by the adjustable bandpass filter 2, and only a specific spectral image is imaged on the camera 5, and the image data of a certain band can be obtained by collecting the sig...

Embodiment 2

[0025] Such as figure 2 , 3 , 4, and 5, in order to obtain a narrower spectrum, two identical adjustable bandpass filters 21 and 22 can be placed and fixed at a certain angle θ, and used as a whole. In this way, the adjustable bandpass filter 21 and the adjustable bandpass filter 22 have certain deviations in the spectral curves transmitted respectively due to the existence of the included angle θ, as shown in image 3 and Figure 4 As shown, the overlapping part is the combined bandwidth, which is narrower than a single adjustable bandpass filter 21 or 22, such as Figure 5 The shaded portion shown. The combined bandwidth depends on the included angle θ. The larger θ is, the narrower the bandwidth is, but it cannot be too large, otherwise the spectral curves of the two adjustable bandpass filters 21 and 22 will not overlap and all cut off. Other parts are the same as in Embodiment 1.

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Abstract

The invention relates to a device for acquiring a multispectral microscopic image. The device for acquiring the multispectral microscopic image comprises a microscope, an adjustable band-pass optical filtering device and a camera which are arranged with the same optical axis, wherein the camera is electrically connected with a computer; the adjustable band-pass optical filtering device is connected with a motor; the motor is controlled by a controller and a computer to rotate or swing to drive the adjustable band-pass optical filtering device to swing in an optical path between a light source of the microscope and the camera; and the adjustable band-pass optical filtering device is one adjustable band-pass optical filtering sheet or two band-pass optical filtering sheets assembled at a certain included angle. Compared with the prior art, the invention has the benefits that: 1) the device for acquiring the multispectral microscopic image has a simple structure and is easy to implement and convenient to operate; 2) the device for acquiring the multispectral microscopic image has high spectral transmittance; 3) the included angle of the adjustable band-pass optical filtering sheet and the optical axis can be continuously changed in the range of 0 to 60 degrees, the expansibility is high and the wavelength can be changed; and 4) the whole system is low in manufacturing cost.

Description

technical field [0001] The invention belongs to the technical field of microscopes, and in particular relates to a multispectral microscopic image acquisition device. Background technique [0002] Compared with ordinary microscopes, multispectral microscopy can obtain one-dimensional information, that is, spectral information, and can provide more accurate quantitative analysis. Therefore, it has important roles in the fields of clinical medicine, pathology, histology, immunohistochemistry, pharmaceutical engineering, and materials science. Value. [0003] Current multispectral microscopes generally use gratings, electrically tunable filter devices (LCTF or AOTF), and color filters to obtain spectral information. For example, Chinese patent ZL200410017031.4 uses gratings to obtain spectral information. The filter device obtains spectral information, although both methods can obtain continuous microscopic images with high spectral resolution, but the cost is relative...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01J3/28G02B5/20
Inventor 陈木旺
Owner MOTIC CHINA GRP CO LTD
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