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Glucosamine gel and preparation method thereof

A technology of glucosamine and gel, applied in the field of glucosamine gel preparation and its preparation, can solve the problems of long onset period, inconvenient administration, etc. Effect

Active Publication Date: 2012-08-01
裕松源药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to overcome the problems of inconvenient administration and long onset period of the existing glucosamine dosage form, the present invention provides an external dosage form of glucosamine dosage form, which is convenient to use and has a fast onset of effect

Method used

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  • Glucosamine gel and preparation method thereof
  • Glucosamine gel and preparation method thereof
  • Glucosamine gel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Take 6Kg of purified water, add glucosamine hydrochloride (calculated as glucosamine) 20g, L-cysteine ​​8g, stir to dissolve. Take 64g of Carbomer 980NF, sprinkle it into the above solution, and stir until it is evenly dispersed, then add 8g of Tween-80, 80g of sodium lauryl sulfate, 2.0L of 1,2-propylene glycol, and 0.01g / mL of paraben Methyl ester ethanol solution 400mL, stir until mixed evenly, adjust pH to 7.0 with triethanolamine, add purified water to 8Kg. The prepared gel is milky white, uniform and delicate paste.

Embodiment 2

[0036] Take 6Kg of purified water, add glucosamine sulfate (calculated as glucosamine) 200g, sodium sulfite 80g, stir to dissolve. Take 160g of carbomer 980NF, sprinkle it into the above solution, and stir until it is evenly dispersed, then add 80g of Tween-80, 160g of dimethylacetamide, 2.2L of 1,2-propanediol, and 8g of potassium sorbate, and stir Mix until uniform, adjust the pH to 7.0 with triethanolamine, and add purified water to 8Kg. The prepared gel is milky white, uniform and delicate paste.

Embodiment 3

[0038] Take 6Kg of purified water, add glucosamine hydrochloride (calculated as glucosamine) 400g, L-cysteine ​​160g, stir to dissolve. Take carbomer 980NF 320g, sprinkle it into the above solution, and stir until it is evenly dispersed, then add 240g of Tween-80, 480g of oleic acid, 2.4L of 1,2-propanediol, and 80g of chlorobutanol, and stir until Mix well, adjust pH to 7.0 with triethanolamine, add purified water to 8Kg. The prepared gel is milky white, uniform and delicate paste.

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Abstract

The invention discloses a glucosamine gel, comprising the following components in percentage by weight: 0.25-5.0 percent of glucosamine hydrochloride or glucosamine sulfate (in the terms of glucosamine), 0.8-4.0 percent of matrix, 25.0-40.0 percent of moisturizer, 1-10.0 percent of skin penetration enhancer, 0-2.0 percent of preservative in which zero is unavailable, 0-6.0 percent of solubilizer in which zero is unavailable, 0-2.0 percent of antioxidant in which zero is unavailable, and the balance of water. The preparation method of the glucosamine gel comprises the following steps of: dissolving glucosamine hydrochloride or glucosamine sulfate in water, adding the other ingredients and stirring till the glucosamine hydrochloride or glucosamine sulfate is dispersed uniformly; regulating a pH value to be 6.0-8.0 and adding water to the total amount; and uniformly stirring to obtain the glucosamine gel. More than 60 percent of glucosamine within 6 hours is released and the glucosamine gel plays roles in administrating medicine at regular point of time and rapidly taking into effect.

Description

technical field [0001] The invention relates to a glucosamine gel preparation and a preparation method thereof. The gel preparation can be used externally to repair and maintain articular cartilage, relieve joint pain, and has convenient administration and remarkable effect. Background technique [0002] Glucosamine, formula C 6 h 13 o 5 N, is the structural unit of cartilage extracellular matrix glycosaminoglycan, hyaluronic acid, and is a natural tissue component of healthy articular cartilage. The main functions of glucosamine as bone and joint medicine are: 1. Repair (or repair) the worn articular cartilage and its surrounding soft tissue, so as to keep the articular surface smooth; 2. Promote the generation of more "synovial fluid" between joints, thereby It can reduce the friction between joints when walking; 3. Anti-inflammatory effect; 4. It has obvious effect and no toxic side effects. The salts of glucosamine include glucosamine hydrochloride and glucosamine s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/7008A61P19/02
Inventor 范文源朱丽顾易凡张航
Owner 裕松源药业有限公司
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