23 results about "Skin penetration enhancer" patented technology

In accordance with the present disclosure, there are provided formulations comprising:(a) at least one active agent;(b) an oil, and optionally a thickener therefor;(c) an organic solvent, and a thickener therefor; and(d) an oil and / or solvent soluble skin penetration enhancer;wherein:said formulation comprises <10 wt % water; andsaid formulation optionally forms a thixotropic thinning gel.Also provided are gels comprising oil and organic solvent, methods for preparing same and methods for the topical delivery of an active agent to a subject in need thereof.

To provide a novel penetration enhancer of royal jelly into skin.SOLUTION: A penetration enhancer into skin of 10-hydroxydecanoic acid and / or 10-hydroxy-2-decenoic acid contained in royal jelly, comprising, as an active ingredient, an (ammonium acryloyldimethyltaurate / methacrylic acid beheneth-25) crosspolymer.SELECTED DRAWING: Figure 1

Embodiments of the invention provide pharmaceutical compositions of ciprofloxacin that are formulated for topical application to a body surface and to have at least a local antibacterial effect. In some embodiments, the compositions are further formulated for localized anti-inflammatory activity, antifungal activity, antiviral activity, or combinations thereof. Such compositions comprise a therapeutically effective amount of non-betaine form of ciprofloxacin (e.g., ciprofloxacin hydrochloride monohydrate); one of a pH adjusting agent of about 5.5 to about 10. In some embodiments, such compositions may be free or devoid of an additional skin penetration enhancer and / or contain betaine form of ciprofloxacin.

The invention relates to the technical field of anti-parasitic implants, and discloses a population wild animal PLGA-based long-acting slow-release anti-parasitic implant, which is composed of the following components in parts by weight: a PLGA carrier, an anti-parasitic composite drug, an auxiliary agent, a skin penetration enhancer, a biological adhesive, a stabilizer, a pH regulator, a plasticizer and an antioxidant. The implant disclosed by the invention can meet the prevention and treatment requirements of the group-living wild animals through functional synergy of all the components: on one hand, the long-acting slow-release performance greatly reduces the administration frequency, the animals do not need to be frequently captured, the interference on group life of the group-living animals is reduced, meanwhile, the investment of manpower and material resources is reduced, and the implant is suitable for large-scale group prevention and treatment; and on the other hand, the implant has excellent physical properties and biocompatibility, and does not cause obvious inflammation or stress response in vivo.

Article side polymers useful in the packaging of transdermal patches are disclosed. These films do not absorb skin permeation enhancers that are contained in transdermal patches including keto acids such as levulinic acid or sulfoxides such as an alkyl sulfoxide, e.g., dimethyl sulfoxide. Using such polymeric film, multilayer pouch constructions can be manufactured which include other polymeric layers, such as aluminum foil for moisture and oxygen barrier properties, polyester for tear resistance and paper layers for optimal printing and design.

The invention relates to thymol-containing hoof bath lotion and a preparation method thereof, the hoof bath lotion comprises the following components in percentage by mass: greater than or equal to 22% of thymol, 22%-27% of a non-aqueous solvent, 10%-12% of a transdermal absorbent, 21%-27% of a surfactant, 0.01%-1.0% of a coloring agent, 0.01%-1.0% of a complexing agent and the balance of water, the surface active agent comprises a first surface active agent, a second surface active agent and a third surface active agent, and the number of the transdermal absorbents is at least two. The hoof bath lotion is high in safety, good in stability and free of obvious irritation, hoof diseases in different stages can be effectively prevented and controlled, the administration condition can be visually marked, omission or repeated administration is avoided, and pasture management is facilitated.

The invention provides a traditional Chinese medicine for relieving itching and diminishing swelling, and relates to the technical field of biological medicine, the traditional Chinese medicine comprises the following components by mass percentage: self-made vinegar accounting for 50%-75% of the total mass of the traditional Chinese medicine, the self-made vinegar is prepared by cooking and saccharifying glutinous rice and polished round-grained rice according to a mass ratio of 1: 1, and fermenting at 6-8 DEG C for 1-2 months; the Chinese herbal medicine semen accounts for 20-45% of the total mass of the traditional Chinese medicines, and the Chinese herbal medicine semen is obtained by mixing a Chinese herbal medicine extracting solution extracted from lysimachia christinae hance and phyllanthus urinaria according to the mass ratio of 1: 1 with honey according to the mass ratio of 4: 1; the skin penetration enhancer accounts for 0.1%-0.3% of the total mass of the traditional Chinese medicine, and the penetration enhancer is a saponin extract; and the acid-base buffer system accounts for 0.1-0.5% of the total mass of the traditional Chinese medicines. The traditional Chinese medicine for relieving itching and diminishing swelling is based on self-made fermented vinegar, Chinese herbal medicine extracts, honey enzymatic hydrolysate and skin permeation enhancing components, a composite, mild and efficient natural external preparation is constructed, and the traditional Chinese medicine can effectively relieve pruritus, inhibit skin inflammation response and promote skin barrier repair.

The invention discloses a spermidine composition for inhibiting aging of hair follicle stem cells and promoting growth period entry and application, and relates to the technical field of biological medicine and functional skin care. The invention discloses a spermidine composition for inhibiting aging of hair follicle stem cells and promoting growth period entry. The skin care product is prepared from the following components in parts by mass: 0.5 to 3 parts of spermidine, 0.2 to 2 parts of an autophagy activator, 0.5 to 4 parts of an antioxidant, 0.1 to 2 parts of a mitochondrial function accelerant, 0.2 to 3 parts of a microcirculation accelerant, 1 to 6 parts of a skin penetration accelerant, 0.2 to 1 part of a preservative, 0.05 to 0.4 part of a pH regulator and 60 to 95 parts of a carrier matrix. The composition can effectively reduce the aging rate of hair follicle stem cells and remarkably improve the proliferation activity of the hair follicle stem cells, active oxygen free radicals around the hair follicle stem cells can be effectively removed by adding the antioxidant of a novel structure, damage of external stimulation to hair follicles is reduced, and a systematic cell protection and repair mechanism is formed.

To provide a composition suitable for topical delivery of cannabidiol to improve availability of cannabidiol at a local administration site of a mammal in a therapeutically effective amount necessary to reduce or alleviate local symptoms of psoriasis or arthritis, such as rheumatoid arthritis, juvenile rheumatoid arthritis, osteoarthritis and / or psoriatic arthritis.SOLUTION: A hydroalcoholic gel composition is disclosed for alleviating symptoms of psoriasis or arthritis, such as pain resulting from arthritic diseases and / or psoriatic arthritis, and / or neurological pain, such as pain resulting from sclerosis, e.g., multiple sclerosis, in a subject. Such a composition may comprise, inter alia, 0.1-20% cannabidiol, a skin penetration enhancer, ethanol, and one or more thickeners and / or gelling agents.SELECTED DRAWING: None

The present disclosure relates to a skin penetration enhancer and a skin penetration enhancing method for infiltrating a physiologically active substance, the skin penetration enhancer containing alpha-glucosyl naringin.

A method of preparing a Polygoni Milletii Rhizome tincture includes: preparing a first mixture; extracting the first mixture with 70-90% ethanol under reflux condition to obtain a first extract solution; preparing a second mixture; extracting the second mixture with 50-70% ethanol to obtain a second extract solution; and mixing the first extract solution with the second extract solution to obtain the polygoni milletii rhizome tincture. A method of preparing a Polygoni Milletii Rhizome poultice includes: reparing a Polygoni Milletii Rhizome mixture; mixing the Polygoni Milletii Rhizome mixture and a skin penetration enhancer in water; mixing a moisturizing agent and a binder in water; adding a thickener in water; mixing methylparaben and ethylparaben in 90% ethanol; mixing all solutions to form a mixture; and applying the mixture on a non-woven fabric cloth and drying to form the Polygoni Milletii Rhizome poultice.

A hydroalcoholic gel composition formulated for topical use is disclosed for alleviating symptoms of psoriasis or arthritis, such as pain resulting from arthritic diseases and / or psoriatric arthritis and / or neurological pain, such as pain resulting from sclerosis, e.g. multiple sclerosis in mammals. Such composition may comprise, inter alia, 0.1-20 % cannabidiol, a skin penetration enhancer, ethanol, and present in an amount of 0.4-2 % (by weight), one or more thickeners or gelling agents, and water in a quantity for the composition to a total of 100 % (by weight).

In accordance with the present disclosure, there are provided formulations comprising:(a) at least one active agent;(b) an oil, and optionally a thickener therefor;(c) an organic solvent, and a thickener therefor; and(d) an oil and / or solvent soluble skin penetration enhancer;wherein:said formulation comprises <10 wt % water; andsaid formulation optionally forms a thixotropic thinning gel.Also provided are gels comprising oil and organic solvent, methods for preparing same and methods for the topical delivery of an active agent to a subject in need thereof.

The present invention provides a cosmetic composition comprising a sebum secretion-regulating and anti-inflammatory functional mRNA nanocomplex as an active ingredient, and use thereof. Specifically, the present invention relates to a cosmetic composition comprising a sebum secretion-regulating and anti-inflammatory functional nanocomplex comprising mRNA as an active ingredient. The nanocomposite comprises (a) an inner core composed of a complex of the mRNA active ingredient and a cationic substance; (b) an intermediate layer surrounding the inner core, containing a lipid and a skin penetration enhancer; and (c) an outer layer surrounding the intermediate layer made of a polymer having pH and enzyme reactivity. The nanocomposite of the present invention exhibits excellent effects in inhibiting skin sebum secretion and reducing inflammatory reactions. Furthermore, the multilayer structure design increases the stability of the active ingredient, enabling it to efficiently pass through the skin barrier to reach the target area.

The present invention provides a topical formulation comprising active ingredient(s) lidocaine, ketamine, or pharmaceutically acceptable salt thereof for dermal application and method of use to treat or relieve pain. The topical formulation comprises active pharmaceutical agents lidocaine, ketamine, or their pharmaceutical salt thereof; one or more skin penetration enhancers; and a drug delivery matrix system. The topical formulations are aimed at relieving pain including any type of pain in body, joint pain, chronic pain states such as post-herpetic neuralgia, complex regional pain syndrome, and arthritis. The topical formulation dries and forms a clear film on the skin and as it comprises water insoluble excipients, it is reasonably wash resistant.

The instant disclosure relates to compositions, especially cosmetic composition, in particular for caring for keratin materials. The cosmetic compositions include at least one skin penetration enhancer; at least three natural moisturizing factors; hydroxyethylpiperazine ethane sulfonic acid. The compositions are useful in methods for improving the appearance of keratin materials.

A hydroalcoholic gel composition formulated for topical use is disclosed for alleviating symptoms of psoriasis or arthritis, such as pain resulting from arthritic diseases and / or psoriatric arthritis and / or neurological pain, such as pain resulting from sclerosis, e.g. multiple sclerosis in mammals. Such composition may comprise, inter alia, 0.1-20 % cannabidiol, a skin penetration enhancer, ethanol, and present in an amount of 0.4-2 % (by weight), one or more thickeners or gelling agents, and water in a quantity for the composition to a total of 100 % (by weight).

Embodiments of the present disclosure disclose the application of glabridin as a skin penetration enhancer in topical skin preparations. The topical skin preparation in this application includes: arbutin and a skin penetration enhancer. This application can promote the skin penetration of arbutin by glabridin, and at the same time can further improve the whitening effect of arbutin.

Provided herein is a transdermal liquid formulation that includes a propionic acid-based non-steroidal anti-inflammatory agent, such as ketoprofen, and a dermal penetration enhancer containing an alcohol, an emollient and an essential oil. Methods of using and making the aforementioned transdermal liquid formulation are also provided herein.

A method for enhancing penetration of a royal jelly into a skin includes blending a carrageenan into a cosmetic composition including the royal jelly. A method for enhancing penetration of a royal jelly into a skin also includes applying a cosmetic composition including a carrageenan and the royal jelly on the skin. A method for producing a cosmetic composition including a royal jelly includes blending a carrageenan into the cosmetic composition for enhancing penetration of the royal jelly into a skin.

The instant disclosure relates to compositions, especially cosmetic composition, in particular for caring for keratin materials. The cosmetic compositions include at least one skin penetration enhancer; at least three natural moisturizing factors; hydroxyethylpiperazine ethane sulfonic acid. The compositions are useful in methods for improving the appearance of keratin materials.

Personal care compositions and methods of use are disclosed herein. A personal care composition is provided comprising: a skin protection system comprising: an amino acid complex; and optionally one or more antioxidants; a penetration enhancer; and a cosmetically acceptable carrier.

The invention relates to an anti-aging composition containing umbilical cord stem cell extract and a preparation method of the anti-aging composition. The composition consists of an umbilical cord stem cell extract, a natural antioxidant, a stabilizer, a skin penetration enhancer and deionized water or a biocompatible solvent, and placenta polypeptide, a basic fibroblast growth factor (bFGF) and an epidermal growth factor (EGF) can also be added as synergistic components. The preparation method comprises the following steps: mixing the components under the protection of inert gas, homogenizing, defoaming, filling, sterilizing and the like. The composition provided by the invention has the advantages of remarkable anti-aging effect, high stability, good safety, high bioavailability and various dosage forms, and can meet different use requirements.