The invention discloses a drinking water filtering system for a high-fluorine region based on dental fluorosis prevention, and belongs to the field of drinking water filtration, the drinking water filtering system for the high-fluorine region based on dental fluorosis prevention comprises a tank body, the upper end of the tank body is communicated with a regeneration flushing pipe, and the lower end of the tank body is communicated with a fluorine removal water inlet pipe; a blocking cylinder is fixedly connected to the inner wall of the tank body, a containing groove is formed in the side wall of the blocking cylinder, an existing defluorination tank is improved, filter materials are arranged to be in a movable splicing mode, washing in the regeneration process is facilitated, fan-shaped filter material bodies which can be spliced into a cylindrical shape are arranged, and the filter materials are combined in the filtering process, so that the filtering efficiency is improved. The fan-shaped filter material bodies are spliced to achieve a normal filtering function, the fan-shaped filter material bodies are dispersed during washing to increase the contact area and range of a regeneration solution and the filter material, so that the regeneration effect is effectively improved, and in addition, the spliced fan-shaped filter material bodies prolong the filtering path and effectively improve the filtering effect.