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Application of glycyrrhizic acid, glycyrrhetinic acid or salt thereof as well as gel composition and preparation method for gel composition

A gel composition and technology of glycyrrhetinic acid, applied in the field of biomedicine, can solve the problems of low efficiency of anti-radiation dermatitis methods, increase the effect of preventing radiation dermatitis, etc., and achieve the effect of promoting healing and moisturizing healing

Inactive Publication Date: 2012-08-01
WUHAN WORLDNER UNITED PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] The purpose of the present invention is to solve the problem that the existing anti-radiation dermatitis method has low efficiency, and provides a kind of application of glycyrrhizic acid, glycyrrhetinic acid or its salt in the preparation of local prevention and treatment of radiodermatitis medicine, and according to this This application provides a combined preparation method of glycyrrhizic acid, glycyrrhetinic acid or its salt and chitosan, the compound biological gel prepared by this method not only has a better therapeutic effect than the current anti-radiation dermatitis drugs, It also increases the effect of preventing radiation dermatitis, which is not available in existing drugs, and is safe, non-toxic and non-irritating to the human body

Method used

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  • Application of glycyrrhizic acid, glycyrrhetinic acid or salt thereof as well as gel composition and preparation method for gel composition
  • Application of glycyrrhizic acid, glycyrrhetinic acid or salt thereof as well as gel composition and preparation method for gel composition

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Effect test

Embodiment 1

[0029] Compound diammonium glycyrrhizinate carboxymethyl chitosan biogel is composed of 0.1% diammonium glycyrrhizinate, 0.1% carboxymethyl chitosan and the rest of water. Mix the diammonium glycyrrhizinate and carboxymethyl chitosan in the prescribed amount, add water, stir evenly, and swell overnight to obtain compound diammonium glycyrrhizinate carboxymethyl chitosan biogel.

Embodiment 2

[0031] Compound Glycyrrhetinic Acid Carboxymethyl Chitosan Biological Gel is composed of 1% glycyrrhetinic acid, 10% carboxymethyl chitosan and the rest of water. Mix glycyrrhetinic acid and carboxymethyl chitosan in prescribed quantities, add water, stir evenly, and swell overnight to obtain compound glycyrrhetinic acid carboxymethyl chitosan biogel.

Embodiment 3

[0033] Compound glycyrrhizic acid carboxymethyl chitosan biogel is composed of 1% glycyrrhizic acid, 2% carboxymethyl chitosan and the rest of water. Mix glycyrrhizic acid and carboxymethyl chitosan in prescribed quantities, add water, stir evenly, and swell overnight to obtain compound glycyrrhizic acid carboxymethyl chitosan biogel.

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Abstract

The invention aims to provide an application of glycyrrhizic acid, glycyrrhetinic acid or salt thereof in preparation of medicines for locally preventing and treating radiodermatitis so as to solve the problem of low effective rate of the conventional anti-radiodermatitis method, and further provides a preparation method for glycyrrhizic acid, glycyrrhetinic acid or salt and chitosan mixing composition according to the application. Compound biological gel prepared by the method has better therapeutic effect compared with that of the conventional anti-radiodermatitis medicine, has the radiodermatitis-preventing effect which the conventional medicine does not have, and is safe, non-toxic and non-irritant for a human body.

Description

technical field [0001] The invention belongs to the field of biomedicine, and specifically relates to the use of glycyrrhizic acid and its decomposition product glycyrrhetinic acid or salts as preparations for local prevention and treatment of anti-radiation dermatitis drugs, and a gel composition of glycyrrhizic acid, glycyrrhetinic acid or salts thereof and its preparation method. [0002] Background technique [0003] Radiation dermatitis is an injury disease caused by various types of ionizing radiation, such as α, β, γ, X-rays, electrons, protons, etc., on the skin and mucous membranes. It occurs first, and if it is not treated in time, radiation skin ulcers will appear and even chronic radiation dermatitis will develop over time, which not only brings pain to patients, but also affects the continuity of treatment, reducing the local control rate and quality of life. [0004] At present, the mechanism of radiation dermatitis is still unclear. Clinically, it mainly pre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/722A61K31/704A61K31/56A61K9/00A61P17/00A61P29/00
Inventor 丁虹岳源武双婵徐东波杨阁
Owner WUHAN WORLDNER UNITED PHARMA
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