Application of isoflavone compound in terms of preparation of medicines for preventing and curing skin injury caused by ultraviolet rays

A technique for skin damage, compounds, used in the field of natural medicinal chemistry and medicine

Inactive Publication Date: 2012-08-15
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] So far, no compounds such as irisin (BC1), irisaxanthin (BC2), irisin-4'-glucoside (BC3), irisinin (BC4), irisin (BC5) and other compounds have any effect on the skin caused by ultraviolet rays. Reports on the protective effect of injury

Method used

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  • Application of isoflavone compound in terms of preparation of medicines for preventing and curing skin injury caused by ultraviolet rays
  • Application of isoflavone compound in terms of preparation of medicines for preventing and curing skin injury caused by ultraviolet rays
  • Application of isoflavone compound in terms of preparation of medicines for preventing and curing skin injury caused by ultraviolet rays

Examples

Experimental program
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Embodiment 1

[0029] Example 1. Protective effect on skin damage caused by ultraviolet radiation

[0030] 1 Experimental drugs and animal materials and methods

[0031] Experimental drugs: irisin BC4(1), irisin BC5(3)

[0032] Drug preparation: irisin BC4(1) and irisin BC5(3) are stored at a concentration of 0.05M, diluted with sesame oil (sesame oil) as a base for use.

[0033] Experimental Animals ICR mice were purchased from the Experimental Animal Center of Second Military Medical University, weighing 20-25 g.

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Abstract

The invention relates to the technical field of natural medicine medicinal chemistry and medicines, provides an isoflavone compound, and particularly relates to a novel use for five compounds including iridin (BC1), tectorigenin (BC2), tectorigenin-4'- heteroside (BC3), irigenin (BC4) and tectoridin (BC5). A model experiment that ultraviolet rays irradiate a mouse to cause skin injury is performed, results show that the BC1, the BC2, the BC3, the BC4 and the BC5 can remarkably improve skin pathology caused by ultraviolet irradiation, for example, skin cutin apoptosis caused by ultraviolet irradiation can be suppressed remarkably, and a remarkable cell protection function is showed; inflammatory response of injured skin tissues after ultraviolet irradiation can be remarkably suppressed; and oxidative damage of homogenate of the injured skin tissues after ultraviolet irradiation can be relieved remarkably. The belamcanda chinensis isoflavone compound can be used for preparing medicines for preventing and curing skin injury caused by the ultraviolet rays.

Description

technical field [0001] The invention relates to the technical fields of natural medicinal chemistry and medicine, and in particular to the application of radix isoflavones in the preparation of medicines for preventing and treating skin damage caused by ultraviolet rays. Background technique [0002] Shegan is the dry rhizome of Belamcanda chinensis (L.) DC. Bitter and cold in taste, enters the liver and lung meridians, has the effects of clearing away heat and detoxification, relieving sore throat and eliminating phlegm, dispersing blood and reducing swelling, and mainly treating sore throat, phlegm, cough and asthma. It is a commonly used Chinese herbal medicine and is rich in resources. Studies have shown that Shegan is rich in isoflavones, which is one of its characteristic components. The main component that the reported Shegan contains is irisgenin, irisaxanthin, hypoirisin, irisflavone neoaglycone A, white sheganin, irisin, irisin etc. (L.Jin, Y.S.Jin, H.S.Chen, at...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K31/352A61P17/16
Inventor 倪鑫陈海生朱晓燕金丽
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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