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Chinese medicinal plaster for treating alcohol-induced osteonecrosis, and preparation method and application thereof

A femoral head necrosis and alcohol-based technology, which is applied in pharmaceutical formulations, medical preparations containing active ingredients, bone diseases, etc., can solve the problems of great pain, high cost, loose artificial femoral head, etc., and achieves convenient use and curative effect. High, short course effect

Inactive Publication Date: 2012-09-26
韦标方
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the improper material of the artificial femoral head and the body's own rejection, many patients have loosening of the artificial femoral head after surgery, and repeated operations are required. The patient suffers a lot and the long-term effect is not good.
At the same time, due to many factors such as strict surgical indications and high cost, surgical treatment is not easily accepted by patients.

Method used

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  • Chinese medicinal plaster for treating alcohol-induced osteonecrosis, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0048] Described plaster preparation method comprises the steps:

[0049] In the first step, the components in the traditional Chinese medicine composition are mixed in proportion and crushed into powders of 200 mesh to 300 mesh;

[0050] In the second step, each component in the matrix is ​​mixed in proportion and stirred to make a matrix;

[0051] The third step is to take sesame oil according to the above-mentioned ratio, heat it to 110-360°C, add the powder obtained in the first step into the sesame oil, extract for 0.5-2 hours, and filter to obtain medicinal residues and medicinal oil for later use;

[0052] Step 4: adding ethanol solution to the dregs for reflux extraction for 0.5-1 hour, filtering, recovering ethanol from the filtrate, concentrating to a relative density of 1.10-1.15, spray-drying to obtain an ethanol extract, and set aside;

[0053] The fifth step is to heat the medicinal oil to 80-120°C, add the ethanol extract, mix well, then add the matrix obtained...

Embodiment 1

[0114] The plaster prepared by embodiment 1 the present invention

[0115] Put 15g of pangolin, 10g of tortoise shell, 10g of Asarum, 15g of rehmannia, 10g of Guiwei, 55g of safflower, 35g of Chuanxiong, 35g of red peony, 15g of white peony, 15g of peach kernel, 10g of earthworm, 15g of clematis, 10g of mulberry, Fenji 15g, Guizhi 15g, Liu Jinu 15g, Shenjincao 25g, Qiannianjian 10g, Wuyao 15g, Qingfengteng 15g, Caulis Spatholobus 25g, Papaya 25g, Eucommia 15g, Psoralen 15g, Cuscuta 15g, Lycium barbarum 25g, Rehmannia glutinosa 15g, Achyranthes bidentata 15g, dog ridge 10g, Cynomorium 10g, Epimedium 15g, Zhichuanwu 15g, Zhifuzi 15g, Rhizoma Cyperi 15g, Curcuma 20g, Salvia miltiorrhiza 15g, Drynaria 15g, Mix 75g astragalus, 15g antler glue, 15g turtle shell, and 15g Morinda officinalis, and grind them into 300-mesh powder. Mix 1200g rosin resin, 270g beeswax, 120g ceramic powder and 420g azone, stir to make a matrix, take sesame oil, and heat to 180°C, add the obtained powder i...

Embodiment 2

[0116] Embodiment 2 clinical experiment

[0117] patient information

[0118] From January 2009 to September 2011, 240 patients with alcoholic avascular necrosis of the femoral head who were hospitalized in the orthopedics department of our hospital were selected, including 147 males and 93 females, aged 22-73 years Between, with an average age of 45.0. The shortest course was 3 months, the longest was 10 years, and the average course was 4 years.

[0119] Diagnostic criteria

[0120] Diagnostic criteria of Western medicine: international general diagnostic criteria for osteonecrosis Mont criteria. TCM standard: the patient has a pale tongue with white or yellow greasy fur, and a slippery and rapid pulse. Symptoms such as mental fatigue, lack of energy, laziness to speak, sleepiness and weight may also be present. Inclusion criteria: ①Patients meeting the above diagnostic criteria; ②Aged 20-75 years; ③According to ARCO staging method III stage and before stage III femoral...

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Abstract

The invention provides a Chinese medicinal plaster for treating alcohol-induced osteonecrosis. The Chinese medicinal plaster comprises Chinese medicinal composition powder, sesame oil and a matrix, wherein the Chinese medicinal composition comprises discorea nipponica makino, tortoise shell, wild ginger, crude rehmannia root, Chinese angelica rootlet, safflower, ligusticum wallichii, red paeony root, white paeony root, peach kernel, earthworm, clematis root, Chinese taxillus twig, hypoglaucous collett yam rhizome, cassia twig, diverse wormwood herb, common clubmoss herb, obscured homalomena rhizome, combined spicebush root, ovientvine, suberect spatholobus stem, pawpaw, cortex eucommiae, malaytea scurfpea fruit, south dodder seed, medlar, prepared rehmannia root, twotooth achyranthes root, east Asian tree fern rhizome, songaria cynomorium herb, epimedium herb, prepared common monkshood mother root, prepared monkshood, nutgrass galingale rhizome, turmeric root tuber, red-rooted salvia root, fortune's drynaria rhizome, astragalus, deerhorn glue, turtle shell and medicinal indianmulberry root. The invention also discloses a preparation method for the Chinese medicinal plaster and application of the Chinese medicinal plaster. The plaster has the advantages of convenience for use, high curative effect, short treatment course and quick response.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine engineering, in particular to a traditional Chinese medicine plaster for treating alcoholic femoral head necrosis. Background technique [0002] Pathogenic factors lead to bone cell nutrition deficiency or complete interruption of bone tissue due to ischemia, inflammation, etc., metabolic disorders, gradual degeneration and necrosis of bone tissue, that is, osteonecrosis, and avascular necrosis of the femoral head that occurs in the femoral head , also known as sterile necrosis. Femoral head necrosis is a relatively stubborn orthopedic disease with many causes. The natural outcome of its development is continuous death of bone cells, fracture of bone trabeculae, gradual appearance of cysts and fragments, bone collapse and secondary osteoarthritis, pain , joint space narrowing, abnormal proliferation of bone fibers, joint dysfunction and disability. [0003] The etiology of f...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61K9/06A61P19/08A61K35/64A61K35/56A61K35/32A61K35/586A61K35/62
Inventor 韦标方葛祥花
Owner 韦标方
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