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Device and method for eliminating biologically harmful substances from bodily fluids

A biological and blood technology, applied in chemical instruments and methods, separation methods, solid adsorbent liquid separation, etc., can solve problems such as unsuccessful removal of endotoxin

Inactive Publication Date: 2012-10-10
HEMOTEQ AG +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Furthermore, despite the beneficial side effects obtained, a feasibility study in 10 patients showed that the concentration of endotoxin was not reduced after plasmapheresis and thus removal of endotoxin was not successful (blood purification (Blood Purif.) 2008;26:.333-339)

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0123] Immobilization of albumin on the outer hollow fiber surface of the device with column I

[0124] 1) Amination of the outer hollow fiber surface

[0125] To prevent the lumens and pores of the hollow fibers from being aminated as well, column I is filled with a water-immiscible solvent (dodecanol in this case) and subsequently drained via the inlet and outlet ports associated with the outer surface. The solvent was dried, followed by careful washing with isotonic saline solution followed by water. The lumen and pores of the hollow fiber remained filled with dodecanol, thereby ensuring that only the outer surface of the hollow fiber was aminated in the following process.

[0126] Flush the cellulose hollow fibers in column I with a solution of 10% polyethyleneimine solution at a rate of 1 ml / s for 60 min at room temperature, whereby the solution passes through the inlet and outlet of column I so that only the hollow The outer surface of the fiber is wetted. Therefore, ...

example 2

[0132] Immobilization of polyamino acids or peptides on polysulfone

[0133] As described in J Polym Sci Part A: Polym Chem 41: 1316-1329, 2003, by reacting hollow fibers or polysulfone particles with Benzonitrile is reacted with an amino group by reduction to benzylamine with cyanoborohydride in acidic medium. Polylysine was then immobilized as described in Example 1 by activating the C-terminal amino acid of polylysine with carbodiimide CME-CDI, followed by reaction of these functional groups with peptide bonds.

[0134] In this way, antimicrobial peptides (AMP) and HDL or cholesterol are bound to hollow fibers or polysulfone particles.

example 3

[0136] immobilization of heparin on particles

[0137] 100 g of the support material in the form of polymethacrylic acid particles were incubated with 300 ml of a 25% (w / v) ammonia solution for 3 hours at room temperature on a slowly rotating rotary evaporator (a stirrer was used to break up the particles). The particles in the reaction solution were then filtered off, and the aminated particles were washed with distilled water until neutral.

[0138] 1.5 g of heparin was completely dissolved in a solution of 220 ml of 0.1 molar MES buffer solution and 7.5 g of CME-CDI at 4°C for 30 minutes. Add this solution to the aminated pellet and rotate overnight at 4 °C.

[0139] Afterwards, non-covalently bound heparin in the modified particles was washed out with a 4 molar NaCl aqueous solution, and then the modified particles were rinsed with water for 30 minutes.

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Abstract

The present invention relates to a device for cleaning blood, blood substitutes, or solutions for introduction into the human and / or animal blood circuit and for exchanging gases in blood, blood substitutes, or solutions for introduction into the human and / or animal blood circuit, comprising at least one gas-permeable membrane and a carrier, which is coated with substances for adsorptively removing toxins of biological and synthetic chemical origin and metabolites and decomposition products thereof present in blood, blood substitutes, or solutions for introduction into the human and / or animal blood circuit, a use of the stated device and a method for gently and simultaneously removing toxins of biological and synthetic chemical origin and metabolites and decomposition products thereof from blood, blood substitutes, or solutions for introduction into the human and / or animal blood circuit and for enriching the blood, blood substitutes, or solutions for introduction into the human and / or animal blood circuit with oxygen.

Description

technical field [0001] The following inventions relate to the purification of blood, blood substitutes or solutions for introduction into the blood circulation of humans and / or animals and for gas exchange in blood, blood substitutes or solutions for introduction into the blood circulation of humans and / or animals A device comprising at least one gas-permeable membrane coated with toxins of biological and chemical synthesis origin, their metabolites and Carriers of substances of degradation products; uses of the aforementioned devices; and for the gentle simultaneous removal of toxins of biological and chemical synthesis origin present in blood, blood substitutes or solutions for introduction into the blood circulation of humans and / or animals, their Metabolites and degradation products and methods for oxygen enrichment of blood, blood substitutes or solutions for introduction into the blood circulation of humans and / or animals. Background technique [0002] Removing harmfu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M1/36A61M1/16A61M1/34B01D15/00B01J20/22B01J20/32
CPCA61M1/34B01D53/228A61M1/3679B01D2313/40B01D53/22A61M2202/20A61M2001/3489A61M2001/3475A61M1/1698B01D63/02A61M1/3475A61M1/3489B01D2325/48A61M1/3616A61M2205/3334A61M1/36A61M2205/3368A61M1/3406A61M1/16A61M1/1623A61M1/3482A61M1/3692A61M2250/00
Inventor 菲特·欧托米雪拉·哈杰克
Owner HEMOTEQ AG
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