A kind of benidipine hydrochloride nanoparticles and preparation method thereof

A beni hydrochloride and dipine nanotechnology, applied in the field of medicine, can solve problems such as large energy and time, and wide crystal particle size distribution

Active Publication Date: 2016-12-14
合肥贝霓医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This method not only consumes huge energy and time, but also has a wide crystal particle size distribution.

Method used

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  • A kind of benidipine hydrochloride nanoparticles and preparation method thereof
  • A kind of benidipine hydrochloride nanoparticles and preparation method thereof
  • A kind of benidipine hydrochloride nanoparticles and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Add 10mL of absolute ethanol to 10g of primary crystals of benidipine hydrochloride, heat to reflux to dissolve, cool down in an ice bath, crystallize with 150W ultrasound for 10min, and filter with suction to obtain pale yellow crystals. figure 1 .

Embodiment 2

[0033] Add 10 mL of methanol to 10.1 g of benidipine hydrochloride primary crystals, heat to reflux to dissolve, cool down in an ice bath, crystallize with 150W ultrasound for 10 minutes, and suction filter to obtain light yellow crystals.

Embodiment 3

[0035] Add 10.2g of primary crystals of benidipine hydrochloride, add 12mL of absolute ethanol, heat to reflux to dissolve, add 12mL of water, cool down in an ice bath, 150W ultrasonic, continue ultrasonication for 2min after crystallization.

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Abstract

The present invention relates to benidipine hydrochloride (±)-(R*)-1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinecarboxylate Nanoparticles of ester [(R*)-1-benzyl-3-piperidinol ester] hydrochloride and its ultrasonic preparation method.

Description

technical field [0001] The invention relates to the technical field of medicine, and is a kind of benidipine hydrochloride (±)-(R * )-1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinecarboxylic acid methyl ester [(R * )-1-benzyl-3-piperidinol ester] hydrochloride nanoparticles and a preparation method thereof. Background technique [0002] Dihydropyridine calcium channel blockers are currently widely used clinically because of their safety and effectiveness. Especially benidipine hydrochloride is an ideal, safe and effective antihypertensive and therapeutic renal agent with its unique three-channel blocking effect, high affinity effect on cell membrane, vascular selective effect and renal protection effect. Drugs for essential hypertension, angina pectoris and other diseases. [0003] Because the solubility of benidipine hydrochloride in water is very low, in order to make benidipine hydrochloride dissolve rapidly from the preparation, it is often necessary to pulve...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D211/90
Inventor 张震姚建忠陈建明张兆勇岳立群陈琼
Owner 合肥贝霓医药科技有限公司
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