2, 2-dihydromethyl propionic acid modified shape memory polyurethane urea material and method for preparing same

A technology of dimethylol propionic acid and polyurethane urea, which is applied in the field of chemistry, can solve the problems of affecting the mechanical properties of materials, disappearing of osteoinductive effect, and is not a solution, so as to achieve excellent hydrolysis resistance, improve biological activity, and improve mechanical properties. The effect of intensity

Inactive Publication Date: 2012-10-24
CHONGQING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing solutions are blending and surface grafting modification: if purely physical mixing, the compound is easy to fall off due to the incompatibility of the two, and it will also affect the mechanical properties of the

Method used

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  • 2, 2-dihydromethyl propionic acid modified shape memory polyurethane urea material and method for preparing same
  • 2, 2-dihydromethyl propionic acid modified shape memory polyurethane urea material and method for preparing same
  • 2, 2-dihydromethyl propionic acid modified shape memory polyurethane urea material and method for preparing same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Accurately weigh D, L-lactide 14.400g (molecular weight 144, distilled and ethyl acetate recrystallization 3 times before weighing) polyethylene glycol 2.667g (molecular weight 400, weighed) according to the molar ratio of 15:1. Molecular sieve to remove water), respectively added to 100ml round bottom flask, add initiator stannous octoate according to 1 / 5000 of the molar weight of D, L-lactide, put it into an oil bath at 130°C for reaction after vacuum sealing 24h. After the reaction, the flask was taken out, cooled naturally and dissolved in dichloromethane, extracted in absolute ethanol, and vacuum-dried to obtain 13.610 g of hydroxyl-terminated macromolecular alcohol. Its molecular weight is 2450 through NMR analysis.

Embodiment 2

[0041] Accurately weigh D, L-lactide 14.400g (molecular weight 144, distilled and ethyl acetate recrystallization 3 times before weighing) polyethylene glycol 2.000g (molecular weight 400, weighed) according to the molar ratio of 20:1. Molecular sieve to remove water), respectively added to 100ml round bottom flask, add initiator stannous octoate according to 1 / 5000 of the molar weight of D, L-lactide, put it into an oil bath at 130°C for reaction after vacuum sealing 24h. After the reaction, the flask was taken out, cooled naturally, dissolved in dichloromethane, extracted in absolute ethanol, and dried in vacuum to obtain 14.013 g of hydroxyl-terminated macromolecular alcohol. Its molecular weight is 2956 according to NMR analysis.

Embodiment 3

[0043]Accurately weigh D, L-lactide 14.400g (molecular weight 144, distilled and ethyl acetate recrystallization 3 times before weighing) polyethylene glycol 1.333g (molecular weight 400, weighed) according to the molar ratio of 30:1. Molecular sieve to remove water), respectively added to 100ml round bottom flask, add initiator stannous octoate according to 1 / 5000 of the molar weight of D, L-lactide, put it into an oil bath at 130°C for reaction after vacuum sealing 24h. After the reaction, the flask was taken out, cooled naturally, and dichloromethane was added to dissolve, extracted in absolute ethanol, and vacuum-dried to obtain 14.408 g of hydroxyl-terminated macromolecule alcohol. Its molecular weight was 4241 by NMR analysis.

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Abstract

The invention relates to a process for modifying a polyurethane urea material, which comprises the following steps: firstly, carrying out vacuum melt reaction of lactide, stannous octoate and polyethylene glycol at 130-170 DEG C to produce hydroxyl-terminated macromolecule alcohol with the molecular weight of 2000-10000; and dissolving the hydroxyl-terminated macromolecule alcohol in the benzene series solvent, adding hexamethylene diisocyanate and a catalyst namely stannous octoate, reacting at 60-80 DEG C to generate a prepolymer, adding 2, 2-dihydromethyl propionic acid to the prepolymer, sufficiently reacting, cooling, adding piperazine, and sufficiently reacting to obtain the 2, 2-dihydromethyl propionic acid modified shape memory polyurethane urea material. By the method, each chain end of the modified material can have uniform carboxyl groups with controllable content; the hydrophilicity of the material can be improved by introducing the carboxyl groups, the cell adhesion is benefited, and the mechanical strength, shape memory performance and biological activity of the material are improved; and the material has better hydrolysis performance through introducing a neopentyl structure, so the degradation speed of the material is favorably reduced.

Description

technical field [0001] The invention relates to the field of chemistry, in particular to a modification process of polyurethane urea materials. Background technique [0002] Bone defect is a common clinical disease, and it is also one of the difficult problems in orthopedic treatment. The so-called bone defect refers to the partial loss of bone caused by trauma, infection, tumor resection or congenital diseases. Bone grafting is currently the main method for clinical treatment of bone defects. [0003] Existing bone repair materials can be divided into autologous bone, allogeneic bone, allogeneic bone, and artificial bone. [0004] For a long time, autologous bone has both osteoconductive and osteoinductive activities, and has a good osteogenic effect, so it has been regarded as the gold standard of bone transplantation. However, the source of autologous bone is limited, and bone extraction not only increases the suffering of patients, but also risks infection, especially...

Claims

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Application Information

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IPC IPC(8): C08G18/73C08G18/66C08G18/48C08G18/34C08G18/32C08G18/10
Inventor 罗彦凤王品品王远亮马宇飞张晓彦
Owner CHONGQING UNIV
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