Heat clearing tablet and preparation method thereof

Abstract

The invention relates to a heat clearing tablet and a preparation method thereof. The preparation method includes steps of taking follum isatidis, rheum officinale, gypsum fibrosum and menthol crystals as active pharmaceutical ingredients and then extracting, granulating, tabletting and coating films, and particularly, treating the follum isatidis by ethanol in a reflux extraction process to obtain extracts, granulating the extracts to obtain granules, preparing the menthol crystals into an inclusion compound, and then mixing the inclusion compound with the granules. Since the follum isatidis is subjected to reflux extraction by the ethanol, the disintegration time of the tablet is short, the appearance of the tablet is good, usage of materials for granulating is reduced while active ingredients keep constant, the output is increased while cost is lowered, and convenience is brought to patients as dosage can be reduced along with increase of effective contents of the tablet. Further, as the inclusion compound is prepared by the menthol crystals and beta-cyclodextrin, the tablet is smooth and flat while the yield is increased. Quality and stability of the film-coated heat-clearing tablet are improved, the preparation method is simple, the production period is shortened, quality controllability is high, detailed production parameters are provided, and thus a basis is provided for large-scale production.

Description

technical field [0001] The invention relates to the field of preparation technology of traditional Chinese medicines, in particular to a Qinghuo tablet and a preparation method thereof. Background technique [0002] Qinghuo tablets prepared according to the standards issued by the Ministry of Health have the functions of clearing heat, purging fire and laxative. It is one of the commonly used Chinese patent medicines in clinical practice. It has definite curative effect and no obvious toxic and side effects reports. . [0003] Ministry of Health Drug Standard WS 3 -The prescription, process and brief description of Qinghuo Tablet given by B-0414-90 are as follows: [0004] Prescription: Folium Folium 400g, Rhubarb 100g, Gypsum 50g, Menthol 0.65g. [0005] Preparation method: the above four flavors, rhubarb and gypsum are crushed into fine powder, and sieved; Folium Folium is boiled twice with water, the first time is 2 hours, the second time is 1 hour, the decoction is co...

AI Technical Summary

Problems solved by technology

[0008] Sugar-coated tablets have the following disadvantages: large tablets, inconvenient to take, not suitable for diabetics, large dust production, long coating time, low degree of automation, large side effects, poor quality of tablets

The disintegration time limit of the prepared tablet is long, there are many spots, the tablet is heavy, the output is small, and the yield is low, and taking 6 tablets each time still brings inconvenience to the patient

[0010] Menthol is dissolved in absolute ethanol and added to the powder for mixing. During the post-production process, there will be many pinholes and wrinkled skin on the surface of the tablet, which will seriously affect the appearance quality of the finished product and the firmness of the coating layer.

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