Triazolyl-containing amino-dithio formic ether compound as well as preparation method and application of compound

Abstract

The invention discloses a triazolyl-containing amino-dithio formic ether compound as well as a preparation method and application of the compound which is taken as a new antineoplastic medicament lead compound, belonging to the field of pharmaceutical chemistry. According to the invention, 1, 2, 3-triazole active fragment is introduced into the structure of amino-dithio formic ether by click chemistry, thus the preparation method is simple, efficient and environment-friendly. The triazolyl-containing amino-dithio formic ether compound has the structure general formula shown in the specification, and has excellent antineoplastic activity for multiple tumour cells, can be used as a candidate or lead compound for the further development to be applied to the preparation of the antineoplastic medicaments.

Description

technical field The invention relates to the field of medicinal chemistry, in particular to a class of triazolyl-containing aminodithiocarbamate compounds, their preparation method and their application as a class of new antitumor drug lead compounds. Background technique Click chemistry was first proposed by the American chemist Sharpless, who won the Nobel Prize in Chemistry in 2001. At present, it mainly refers to the reaction of azide compounds and alkyne compounds catalyzed by Cu(I) to generate 1, 2, 3-triazole penta Reactions of ring compounds. Due to its mild reaction conditions, high yield, simple product post-treatment and many other advantages, it has been widely used in the optimization of drug lead compounds and the construction of compound libraries. 1, 2, 3-triazoles exhibit a variety of interesting biological activities, such as antibacterial, anti-inflammatory, anti-allergic, anti-tuberculosis, anti-HIV activities, etc. Many marketed drugs have 1, 2, 3-tria...

AI Technical Summary

Problems solved by technology

Using click chemistry to introduce the 1,2,3-triazole active fragment into the carbamate structure to synthesize a new triazole-containing carbamodithiocarbamate compound, there is no relevant literature report so far