Portable forward photoacoustic microscope based on optical resolution

Abstract

The invention provides a portable forward photoacoustic microscopy based on optical resolution. The photoacoustic microscopy comprises a laser diode, a collimating lens, a focusing lens, protective glasses, a shell, a stage, an ultrasonic coupling liquid, an ultrasonic sensor, a lifting platform, a 3D motorized translation stage, a motor driving circuit, a computer, a data acquisition circuit, a signal pretreatment circuit, a clock circuit and a driving power circuit. According to the invention, miniature, inexpensive and easily maintained laser diode is applied to the field of optical resolution photoacoustic microscopy excitation. The portable forward photoacoustic microscope has the advantages of portable volume, high resolution, large imaging depth and simple signal post-treatment circuit, and is quite suitable for nondestructive testing of thin materials or tissue samples.

Description

technical field [0001] The invention relates to a photoacoustic microscopic imaging technology, in particular to a portable forward photoacoustic microscope based on optical resolution. Background technique [0002] Photoacoustic microscopy is a newly developed imaging technology, which can realize high-resolution detection images ranging from hundreds of microns to tens of nanometers, and has the advantages of high optical contrast, no radiation damage, and safe and convenient use. It can be divided into acoustic resolution and optical resolution modes. The photoacoustic microscopic imaging technology of the acoustic resolution mode was first developed, and its lateral resolution is mainly determined by the main frequency of the focused ultrasonic sensor. The higher the frequency, the higher the resolution, generally in the hundreds of microns to several microns between. However, due to the faster attenuation of ultra-high frequency components, the imaging depth is severe...

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Problems solved by technology

In 2012, Yuan et al reported an optical resolution forward photoacoustic microscope using two-dimensional laser galvanometer scanning (Y. Yuan, Si Yang and D. Xing, “Optical-resolution photoacoustic microscopy based on two-dimensional scanning galvanometer,” Appl . Phys. Lett. 100, 023702, 2012), but the above technologies use relatively high-power solid-state lasers as photoacoustic excitation sources, and such lasers usually have many disadvantages such as large volume, high price, and difficult maintenance, and it is difficult to implement a system The miniaturization and portable design, obviously there are considerable limitations in practical application

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