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Application of Aphanamixoid A in medicine for treating acute renal failure

A technology for acute renal failure and drugs, applied in the direction of drug combination, urinary system diseases, etc., to achieve obvious therapeutic effects

Inactive Publication Date: 2013-01-09
NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are few clinical drugs that have obvious effects on improving renal blood perfusion disorder and reducing renal tissue damage

Method used

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  • Application of Aphanamixoid A in medicine for treating acute renal failure
  • Application of Aphanamixoid A in medicine for treating acute renal failure
  • Application of Aphanamixoid A in medicine for treating acute renal failure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1: the preparation of compound Aphanamixoid A tablet involved in the present invention:

[0013] Get 20 grams of compound Aphanamixoid A, add 180 grams of conventional adjuvants for preparing tablets, mix evenly, and make 1000 tablets on a conventional tablet press.

Embodiment 2

[0014] Embodiment 2: the preparation of compound Aphanamixoid A capsules involved in the present invention:

[0015] Get 20 grams of compound Aphanamixoid A, add conventional auxiliary materials for preparing capsules such as 180 grams of starch, mix well, and pack into capsules to make 1000 tablets.

[0016] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example 1

[0017] Experimental example 1 Therapeutic effect of Aphanamixoid A on rats with acute renal failure

[0018] (1) Experimental method

[0019] Rat animal model of acute renal failure induced by intramuscular injection of glycerol. Sixty healthy male SD rats of 180-220g were selected and randomly divided into 5 groups: sham operation group (intramuscular injection of saline); model group (intramuscular injection of glycerol); Aphanamixoid A Ⅰ group (0.3 mg / Kg); Aphanamixoid A Ⅱ group (0.6 mg / Kg); Aphanamixoid A group III (1.2 mg / Kg), the rats in each group were injected with normal saline or Aphanamixoid A through the tail vein immediately after glycerol modeling, and then administered again after 12 and 24 hours.

[0020] (2) Observation indicators

[0021] After the last administration of Aphanamixoid A or normal saline, 60 rats were put into metabolic cages to collect urine for 24 hours, and were anesthetized by intraperitoneal injection of 4% chloral hydrate 6 hours after ...

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PUM

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Abstract

The invention relates to novel medicinal application of Aphanamixoid A, namely application of Aphanamixoid A in preparing a medicine for treating acute renal failure. The application of Aphanamixoid A in preparing the medicine for treating acute renal failure, which is provided by the invention, is disclosed for the first time. The skeleton type belongs to brand-new skeleton type, and the acute renal failure preventing activity of Aphanamixoid A is extremely strong, so that no possibility for providing any prompt by other compounds exists. Aphanamixoid A has outstanding actual characteristics. Meanwhile, Aphanamixoid A has outstanding progress when being used for preventing acute renal failure.

Description

technical field [0001] The present invention relates to the field of medicinal chemistry. Specifically, the present invention relates to a new medical application of Aphanamixoid A, that is, the application of Aphanamixoid A in the preparation of medicines for treating acute renal failure. Background technique [0002] Acute Renal Failure (ARF) is a clinical syndrome caused by a variety of reasons, which can be seen in patients from various clinical departments. It has a high incidence and often brings serious consequences. ) sharp decline in mental function, clinical manifestations of acute oliguria (urine output <400mLPd) or anuria (urine output <100mLPd), obstacles in the excretion of nitrogen metabolites in the body, rapid azotemia, water and electrolytes, acid-base Balance disorder, and cause the corresponding dysfunction of the system of the whole body. The main factors causing acute renal failure are the sharp reduction of renal blood flow, as well as the oxid...

Claims

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Application Information

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IPC IPC(8): A61K31/365A61P13/12
Inventor 冯怡龚霞吴俊华
Owner NANJING UNIV