Application of Houttuynoid B in anti-human fungi medicine

A technology of anti-fungi and drugs for human body, applied in the direction of anti-fungal agents, medical preparations containing active ingredients, pharmaceutical formulations, etc., can solve the problems of strong accumulation of toxicity, irritation of digestive tract, etc., and achieve strong anti-fungal activity and outstanding essence The effect of sexuality

Active Publication Date: 2013-05-15
刘骏
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The spread of pathogenic bacteria and the enhancement of drug resistance seriously threaten human health and life. Antibacterial drugs have been widely used as routine drugs in the treatment of AIDS, organ transplantation and chronic wasting diseases (such as cancer, diabetes, uremia, etc.) Treatment, although antibacterial agents currently used clinically (such as ketoconazole, amikacin, gentamicin, vigorconazole, itraconazole, terbinafine, amphotericin, fluconazole, etc.) The curative effect on skin and superficial infection is good, but these antibacterial drugs have strong cumulative toxicity, often causing liver and kidney damage, gastrointestinal irritation, dizziness, allergies, etc. one of the hotspots

Method used

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  • Application of Houttuynoid B in anti-human fungi medicine
  • Application of Houttuynoid B in anti-human fungi medicine
  • Application of Houttuynoid B in anti-human fungi medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1: the preparation of compound Houttuynoid B tablet involved in the present invention:

[0013] Take 20 grams of compound Houttuynoid B, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tablet press machine.

Embodiment 2

[0014] Embodiment 2: the preparation of compound Houttuynoid B capsules involved in the present invention:

[0015] Take 20 grams of compound Houttuynoid B, add conventional auxiliary materials for preparing capsules such as 180 grams of starch, mix well, and pack into capsules to make 1000 tablets.

[0016] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example

[0017] Experimental example: Anti-fungal activity of Houttuynoid B in humans

[0018] Anti-human fungus activity experiment is the method of concentration dilution, each measurement is repeated three times, the test pathogens include Trichomonas rubrum, Microsporum lanoides and Phytophthora clematis, and the concentration of bacteria solution is 10 5 individual / mL. The initial concentration of Houttuynoid B is 50.0 μg / mL (5% dimethyl sulfoxide DMSO), serially diluted to 0.098 μg / mL, and the same volume of bacterial liquid and test samples are mixed and cultured in a 96-well plate, and the human fungal culture temperature 28 ℃ respectively, observe after 24 hours of incubation time, if no colony is found, it is the lowest anti-human fungal concentration of the sample, that is, the MIC value. The positive control of this experiment is ketoconazole, and the results of Houttuynoid B against human fungi are shown in Table 1.

[0019] Table 1 Houttuynoid B anti-human fungal MIC va...

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Abstract

The invention relates to application of Houttuynoid B in preparation of an anti-human fungi medicine, belonging to the technical field of new application of medicine. Houttuynoid B has very strong effect on inhibition of epidrmophyton rubrum, microsporum lanosum or trichophyton tonsurans, so that Houttuynoid B is taken as an anti-human fungi compound and is expected to be applied to the preparation of the relative medicines. The application of Houttuynoid B in preparation of the anti-human fungi medicine provided by the invention is disclosed firstly. The skeleton type belongs to new skeletontype, and the activity of Houttuynoid B on inhibition of human fungi is unexpectedly strong; and the probability that any revelation is provided by other compounds does not exist, Houttuynoid B has the excellent substantive features, and Houttuynoid B obviously has a remarkable progress when being used for preventing and treating human fungi infection.

Description

technical field [0001] The invention relates to the application of Houttuynoid B, in particular to the application of Houttuynoid B in the preparation of antifungal drugs for human body. Background technique [0002] The spread of pathogenic bacteria and the enhancement of drug resistance seriously threaten human health and life. Antibacterial drugs have been widely used as routine drugs in the treatment of AIDS, organ transplantation and chronic wasting diseases (such as cancer, diabetes, uremia, etc.) Treatment, although antibacterial agents currently used clinically (such as ketoconazole, amikacin, gentamicin, vigorconazole, itraconazole, terbinafine, amphotericin, fluconazole, etc.) The curative effect on skin and superficial infection is good, but these antibacterial drugs have strong accumulation toxicity, often causing liver and kidney damage, gastrointestinal irritation, dizziness, allergies, etc. one of the hotspots. [0003] The compound Houttuynoid B involved in...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61P31/10
Inventor 张广王泽正吴俊华
Owner 刘骏
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