Method for measuring crystal form proportion in compound in quantitative mode
A technique for quantitative determination of compounds, applied in the field of quantitative determination of crystal form ratios in compounds, can solve problems such as methods for determining the proportion of different crystal forms of compounds that have not yet been seen, and achieve the effects of easy promotion, simple operation, and low cost
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Embodiment 1
[0070] c. The closer the correlation coefficient R of the relationship curve is to 1, the better the linearity of the relationship curve and the higher the accuracy of the method. Example 1 Determination of the ratio of linezolid crystalline form II to crystalline form IV (quantitative wavenumbers are 852 ± 2cm -1 With 825±2cm -1 )11 respectively select the quantitative wavenumbers of linezolid crystal form II and linezolid crystal form IV
[0071] 1.1.1 Weigh an appropriate amount of pure linezolid crystal form II, grind to form particles smaller than 1 micron, and then mix these particles with potassium bromide powder at a ratio of 1:200 (mass ratio), and mix the mixed The powder was pressed into a tablet to form a thin sheet sample with a thickness of about 0.5-1 mm. The blank potassium bromide tablet was used as a background for reference, and infrared scanning was carried out 15 times to obtain the crystal form II of linezolid at 4000-400 cm. -1 For infrared absorption ...
Embodiment 2
[0081] Example 2 Determination of the ratio of linezolid crystal form II to crystal form IV (quantitative wavenumbers are 1445 ± 2 cm -1 With 1425±2cm -1 )
[0082] 2.1 Select the quantitative wavenumbers of Linezolid Form II and Linezolid Form IV respectively
[0083] According to the method in 1.1.1, the crystal form IV of linezolid was obtained at 4000-400cm -1 Infrared absorption band within the range; according to the method in 1.1.2, the crystal form IV of linezolid was obtained at 4000~400cm -1 range of infrared absorption bands.
[0084] Comparing the infrared absorption band of the crystal form II with the infrared absorption band of the crystal form IV, it is found that the crystal form II is at 1445±2cm -1 There is a sharp absorption peak at , while the crystal form IV has no absorption peak at this place; the crystal form IV is at 1425±2cm -1 There is a sharp absorption peak at , while the crystal form II has no absorption peak at this position. Therefore, ch...
Embodiment 3
[0092] Example 3 Determination of the ratio of linezolid crystalline form II to crystalline form IV (quantitative wavenumbers are 679±2cm -1 With 661±2cm -1 )
[0093] 3.1 Select the quantitative wavenumbers of Linezolid Form II and Linezolid Form IV respectively
[0094] According to the method in 1.1.1, the crystal form IV of linezolid was obtained at 4000-400cm -1Infrared absorption band within the range; according to the method in 1.1.2, the crystal form IV of linezolid was obtained at 4000~400cm -1 range of infrared absorption bands.
[0095] Comparing the infrared absorption band of the crystal form II with the infrared absorption band of the crystal form IV, it is found that the crystal form II is at 679±2cm -1 There is a sharp absorption peak at , while the crystal form IV has no absorption peak at this place; the crystal form IV is at 661±2cm -1 There is a sharp absorption peak at , while the crystal form II has no absorption peak at this position. Therefore, ch...
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